60651

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 52528..53204 Replicon plasmid unnamed2
Accession NZ_CP014309
Organism Burkholderia sp. PAMC 26561

Toxin (Protein)


Gene name tad Uniprot ID A0A109WQK9
Locus tag AXG89_RS26935 Protein ID WP_062174144.1
Coordinates 52848..53204 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A109WUF4
Locus tag AXG89_RS26930 Protein ID WP_062174010.1
Coordinates 52528..52851 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXG89_RS26915 47728..50601 + 2874 WP_062174150.1 hypothetical protein -
AXG89_RS26920 50623..51189 - 567 WP_062174013.1 hypothetical protein -
AXG89_RS26925 51868..52365 + 498 WP_062174012.1 hypothetical protein -
AXG89_RS26930 52528..52851 - 324 WP_062174010.1 helix-turn-helix domain-containing protein Antitoxin
AXG89_RS26935 52848..53204 - 357 WP_062174144.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AXG89_RS26940 53326..54942 - 1617 WP_062174008.1 hypothetical protein -
AXG89_RS26945 55051..55545 - 495 WP_069638467.1 hypothetical protein -
AXG89_RS26950 55535..57397 - 1863 WP_062174140.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA 1..793876 793876


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-85)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13114.25 Da        Isoelectric Point: 9.7653

>T60651 WP_062174144.1 NZ_CP014309:c53204-52848 [Burkholderia sp. PAMC 26561]
MENIKTLRWIASSKKDLKAMPEVVQDTFGFALHQAQIGLKHVDAKALKGFGSAGVLEVVESAEGGTYRAVYTVRFADAVY
VLHCFQKKATHGIATPKPDMDLIRDRLKIAEELAKERK

Download         Length: 357 bp

>T60651 NZ_CP014309:c53204-52848 [Burkholderia sp. PAMC 26561]
ATGGAAAACATCAAGACTCTGCGCTGGATAGCGTCTTCCAAGAAAGACCTGAAAGCGATGCCCGAAGTCGTACAAGACAC
TTTTGGATTCGCGCTGCATCAGGCCCAGATAGGTCTTAAACACGTGGACGCGAAGGCGCTCAAGGGATTTGGTTCTGCGG
GAGTGCTTGAAGTGGTCGAATCGGCGGAAGGCGGGACTTACCGGGCGGTCTACACGGTGCGTTTTGCCGACGCGGTGTAT
GTGCTGCATTGCTTTCAAAAGAAAGCGACCCACGGAATCGCGACACCGAAGCCGGATATGGACCTGATCAGAGATAGACT
CAAGATCGCGGAAGAACTTGCCAAGGAAAGGAAATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11688.52 Da        Isoelectric Point: 8.9999

>AT60651 WP_062174010.1 NZ_CP014309:c52851-52528 [Burkholderia sp. PAMC 26561]
MTDYEESSGNVYTDLGLADAEEMLVKAQLASKIGEIIKGRRWTQQQAAEVLGMTQPKLSNLLRGQFRGVSEAKMLECLAK
LGRDVKIVVGPARRSTKPGHVEVVFAA

Download         Length: 324 bp

>AT60651 NZ_CP014309:c52851-52528 [Burkholderia sp. PAMC 26561]
ATGACCGACTACGAAGAAAGCAGCGGCAATGTCTATACTGACTTAGGATTGGCCGATGCGGAGGAAATGCTAGTCAAGGC
GCAACTCGCCTCAAAGATTGGCGAGATCATCAAGGGCCGCCGATGGACGCAACAGCAAGCAGCGGAAGTGCTGGGCATGA
CACAACCCAAGCTGTCCAATTTGCTGCGCGGTCAATTCCGTGGTGTTAGTGAAGCGAAGATGCTCGAATGTCTCGCCAAA
CTTGGGCGTGACGTAAAAATCGTTGTCGGCCCGGCACGCCGTTCGACCAAACCGGGCCATGTTGAAGTGGTGTTTGCTGC
ATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A109WQK9

Antitoxin

Source ID Structure
AlphaFold DB A0A109WUF4

References