60650

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 781894..782570 Replicon plasmid unnamed1
Accession NZ_CP014308
Organism Burkholderia sp. PAMC 26561

Toxin (Protein)


Gene name tad Uniprot ID A0A109WQK9
Locus tag AXG89_RS26590 Protein ID WP_062174144.1
Coordinates 781894..782250 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A109WUF4
Locus tag AXG89_RS26595 Protein ID WP_062174010.1
Coordinates 782247..782570 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXG89_RS26575 777701..779563 + 1863 WP_062174140.1 hypothetical protein -
AXG89_RS26580 779553..780047 + 495 WP_069638467.1 hypothetical protein -
AXG89_RS26585 780156..781772 + 1617 WP_062174008.1 hypothetical protein -
AXG89_RS26590 781894..782250 + 357 WP_062174144.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AXG89_RS26595 782247..782570 + 324 WP_062174010.1 helix-turn-helix domain-containing protein Antitoxin
AXG89_RS26600 782733..783230 - 498 WP_062174012.1 hypothetical protein -
AXG89_RS26605 783905..784471 + 567 WP_062174013.1 hypothetical protein -
AXG89_RS26610 784493..785272 - 780 WP_062174015.1 hypothetical protein -
AXG89_RS26615 785597..785893 + 297 WP_162916149.1 hypothetical protein -
AXG89_RS26620 785855..787258 - 1404 WP_162916150.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA 1..793818 793818


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-85)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13114.25 Da        Isoelectric Point: 9.7653

>T60650 WP_062174144.1 NZ_CP014308:781894-782250 [Burkholderia sp. PAMC 26561]
MENIKTLRWIASSKKDLKAMPEVVQDTFGFALHQAQIGLKHVDAKALKGFGSAGVLEVVESAEGGTYRAVYTVRFADAVY
VLHCFQKKATHGIATPKPDMDLIRDRLKIAEELAKERK

Download         Length: 357 bp

>T60650 NZ_CP014308:781894-782250 [Burkholderia sp. PAMC 26561]
ATGGAAAACATCAAGACTCTGCGCTGGATAGCGTCTTCCAAGAAAGACCTGAAAGCGATGCCCGAAGTCGTACAAGACAC
TTTTGGATTCGCGCTGCATCAGGCCCAGATAGGTCTTAAACACGTGGACGCGAAGGCGCTCAAGGGATTTGGTTCTGCGG
GAGTGCTTGAAGTGGTCGAATCGGCGGAAGGCGGGACTTACCGGGCGGTCTACACGGTGCGTTTTGCCGACGCGGTGTAT
GTGCTGCATTGCTTTCAAAAGAAAGCGACCCACGGAATCGCGACACCGAAGCCGGATATGGACCTGATCAGAGATAGACT
CAAGATCGCGGAAGAACTTGCCAAGGAAAGGAAATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11688.52 Da        Isoelectric Point: 8.9999

>AT60650 WP_062174010.1 NZ_CP014308:782247-782570 [Burkholderia sp. PAMC 26561]
MTDYEESSGNVYTDLGLADAEEMLVKAQLASKIGEIIKGRRWTQQQAAEVLGMTQPKLSNLLRGQFRGVSEAKMLECLAK
LGRDVKIVVGPARRSTKPGHVEVVFAA

Download         Length: 324 bp

>AT60650 NZ_CP014308:782247-782570 [Burkholderia sp. PAMC 26561]
ATGACCGACTACGAAGAAAGCAGCGGCAATGTCTATACTGACTTAGGATTGGCCGATGCGGAGGAAATGCTAGTCAAGGC
GCAACTCGCCTCAAAGATTGGCGAGATCATCAAGGGCCGCCGATGGACGCAACAGCAAGCAGCGGAAGTGCTGGGCATGA
CACAACCCAAGCTGTCCAATTTGCTGCGCGGTCAATTCCGTGGTGTTAGTGAAGCGAAGATGCTCGAATGTCTCGCCAAA
CTTGGGCGTGACGTAAAAATCGTTGTCGGCCCGGCACGCCGTTCGACCAAACCGGGCCATGTTGAAGTGGTGTTTGCTGC
ATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A109WQK9

Antitoxin

Source ID Structure
AlphaFold DB A0A109WUF4

References