Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 305287..306212 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP014308 | ||
| Organism | Burkholderia sp. PAMC 26561 | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | A0A109WV41 |
| Locus tag | AXG89_RS24325 | Protein ID | WP_062173350.1 |
| Coordinates | 305287..305808 (-) | Length | 174 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | A0A120KZ63 |
| Locus tag | AXG89_RS24330 | Protein ID | WP_062173352.1 |
| Coordinates | 305805..306212 (-) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AXG89_RS24305 | 300900..301385 | - | 486 | WP_082771651.1 | OsmC family protein | - |
| AXG89_RS24310 | 301673..303181 | - | 1509 | WP_205583095.1 | sigma 54-interacting transcriptional regulator | - |
| AXG89_RS24315 | 304355..304693 | - | 339 | WP_062173346.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| AXG89_RS24320 | 304690..304926 | - | 237 | WP_062173348.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| AXG89_RS24325 | 305287..305808 | - | 522 | WP_062173350.1 | RES family NAD+ phosphorylase | Toxin |
| AXG89_RS24330 | 305805..306212 | - | 408 | WP_062173352.1 | hypothetical protein | Antitoxin |
| AXG89_RS24335 | 306791..307096 | + | 306 | WP_062173354.1 | flagellar biosynthesis anti-sigma factor FlgM | - |
| AXG89_RS24340 | 307496..307864 | + | 369 | WP_082771594.1 | RHS repeat-associated core domain-containing protein | - |
| AXG89_RS24345 | 308025..308654 | + | 630 | WP_062173356.1 | hypothetical protein | - |
| AXG89_RS24350 | 308662..309789 | - | 1128 | WP_062173358.1 | AAA family ATPase | - |
| AXG89_RS24355 | 310226..310492 | + | 267 | WP_082771595.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| AXG89_RS24360 | 310492..310812 | + | 321 | WP_062173360.1 | CcdB family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | katA | 1..793818 | 793818 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 174 a.a. Molecular weight: 19327.90 Da Isoelectric Point: 5.5777
>T60648 WP_062173350.1 NZ_CP014308:c305808-305287 [Burkholderia sp. PAMC 26561]
MIFANLFNVTVYRMLVPKWAVAPMSGAGAGTHGGRANRVGLNALYLALDHDTAVREYQQLSSLMPPGTLVSYSLTATPIV
DFTGGYESGKWSPLWEDFYCDWRHCWFNERIEPPSWIIGDEVVLSGAKGILFKSRLTPNGTNLVLYTENFDPTDRLDVFD
PHNALPKNQSSWG
MIFANLFNVTVYRMLVPKWAVAPMSGAGAGTHGGRANRVGLNALYLALDHDTAVREYQQLSSLMPPGTLVSYSLTATPIV
DFTGGYESGKWSPLWEDFYCDWRHCWFNERIEPPSWIIGDEVVLSGAKGILFKSRLTPNGTNLVLYTENFDPTDRLDVFD
PHNALPKNQSSWG
Download Length: 522 bp
>T60648 NZ_CP014308:c305808-305287 [Burkholderia sp. PAMC 26561]
ATGATTTTTGCGAACCTGTTTAACGTAACCGTATATCGGATGCTCGTCCCGAAGTGGGCAGTCGCGCCGATGAGCGGCGC
TGGAGCAGGAACGCATGGCGGTCGTGCGAATCGTGTCGGACTCAACGCGCTTTACCTCGCATTGGATCACGACACTGCCG
TCAGAGAGTATCAGCAACTCTCGTCCTTGATGCCACCAGGGACGCTGGTTAGCTACAGCCTCACGGCCACCCCTATAGTC
GATTTCACCGGTGGATACGAGAGTGGCAAGTGGTCTCCTTTGTGGGAGGATTTTTATTGCGATTGGCGCCACTGCTGGTT
CAATGAACGGATCGAGCCACCCAGTTGGATCATCGGCGATGAGGTCGTCTTGAGCGGCGCCAAAGGTATCCTCTTCAAAT
CACGACTAACACCTAACGGCACGAATCTCGTTCTGTACACAGAGAATTTCGACCCAACCGATCGTCTCGACGTTTTCGAT
CCGCACAATGCACTACCGAAGAATCAGTCGTCGTGGGGTTGA
ATGATTTTTGCGAACCTGTTTAACGTAACCGTATATCGGATGCTCGTCCCGAAGTGGGCAGTCGCGCCGATGAGCGGCGC
TGGAGCAGGAACGCATGGCGGTCGTGCGAATCGTGTCGGACTCAACGCGCTTTACCTCGCATTGGATCACGACACTGCCG
TCAGAGAGTATCAGCAACTCTCGTCCTTGATGCCACCAGGGACGCTGGTTAGCTACAGCCTCACGGCCACCCCTATAGTC
GATTTCACCGGTGGATACGAGAGTGGCAAGTGGTCTCCTTTGTGGGAGGATTTTTATTGCGATTGGCGCCACTGCTGGTT
CAATGAACGGATCGAGCCACCCAGTTGGATCATCGGCGATGAGGTCGTCTTGAGCGGCGCCAAAGGTATCCTCTTCAAAT
CACGACTAACACCTAACGGCACGAATCTCGTTCTGTACACAGAGAATTTCGACCCAACCGATCGTCTCGACGTTTTCGAT
CCGCACAATGCACTACCGAAGAATCAGTCGTCGTGGGGTTGA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14822.60 Da Isoelectric Point: 5.6485
>AT60648 WP_062173352.1 NZ_CP014308:c306212-305805 [Burkholderia sp. PAMC 26561]
MNSNADATVPGADVGFDRFMASLRDPNDPAPIVSARRFGEALHIDLQTLAQQAHVHRNTISRQPASESVQRFLRDALRVI
RAATDLAGDVSKALFWYRNEPLPVFDYKTAEQLVSEGRADDIIRFVASLETGAAG
MNSNADATVPGADVGFDRFMASLRDPNDPAPIVSARRFGEALHIDLQTLAQQAHVHRNTISRQPASESVQRFLRDALRVI
RAATDLAGDVSKALFWYRNEPLPVFDYKTAEQLVSEGRADDIIRFVASLETGAAG
Download Length: 408 bp
>AT60648 NZ_CP014308:c306212-305805 [Burkholderia sp. PAMC 26561]
ATGAACTCAAATGCAGATGCGACCGTTCCCGGCGCAGATGTTGGTTTTGATCGATTTATGGCGTCGTTGCGTGACCCAAA
CGACCCCGCACCGATTGTGTCGGCCCGTCGATTCGGCGAGGCTTTGCATATTGACTTGCAGACCCTGGCGCAGCAAGCGC
ACGTGCACCGAAATACGATCAGCAGGCAACCTGCGTCCGAAAGCGTACAACGGTTTCTTCGCGATGCCCTAAGGGTGATC
CGCGCCGCGACTGATCTTGCAGGCGACGTCTCGAAGGCGCTTTTTTGGTACAGAAACGAACCCCTCCCCGTGTTCGACTA
TAAAACCGCCGAACAATTGGTATCCGAAGGTCGGGCCGACGATATCATCCGTTTCGTTGCATCCCTCGAAACGGGCGCGG
CGGGATGA
ATGAACTCAAATGCAGATGCGACCGTTCCCGGCGCAGATGTTGGTTTTGATCGATTTATGGCGTCGTTGCGTGACCCAAA
CGACCCCGCACCGATTGTGTCGGCCCGTCGATTCGGCGAGGCTTTGCATATTGACTTGCAGACCCTGGCGCAGCAAGCGC
ACGTGCACCGAAATACGATCAGCAGGCAACCTGCGTCCGAAAGCGTACAACGGTTTCTTCGCGATGCCCTAAGGGTGATC
CGCGCCGCGACTGATCTTGCAGGCGACGTCTCGAAGGCGCTTTTTTGGTACAGAAACGAACCCCTCCCCGTGTTCGACTA
TAAAACCGCCGAACAATTGGTATCCGAAGGTCGGGCCGACGATATCATCCGTTTCGTTGCATCCCTCGAAACGGGCGCGG
CGGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A109WV41 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A120KZ63 |