Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 129327..130252 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP014308 | ||
| Organism | Burkholderia sp. PAMC 26561 | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | A0A0X8LAF1 |
| Locus tag | AXG89_RS23535 | Protein ID | WP_062172842.1 |
| Coordinates | 129327..129848 (-) | Length | 174 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | A0A0X8LAL5 |
| Locus tag | AXG89_RS23540 | Protein ID | WP_062172844.1 |
| Coordinates | 129845..130252 (-) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AXG89_RS23495 | 124760..125317 | - | 558 | WP_082771581.1 | LUD domain-containing protein | - |
| AXG89_RS23500 | 125356..125613 | - | 258 | WP_119024714.1 | DUF3390 domain-containing protein | - |
| AXG89_RS23505 | 125724..126215 | - | 492 | WP_062172834.1 | hypothetical protein | - |
| AXG89_RS23510 | 126230..127753 | - | 1524 | WP_062172836.1 | IS66 family transposase | - |
| AXG89_RS23515 | 127804..128151 | - | 348 | WP_162916115.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| AXG89_RS23520 | 128145..128567 | - | 423 | WP_062172838.1 | hypothetical protein | - |
| AXG89_RS23530 | 128959..129174 | + | 216 | WP_062172840.1 | hypothetical protein | - |
| AXG89_RS23535 | 129327..129848 | - | 522 | WP_062172842.1 | RES family NAD+ phosphorylase | Toxin |
| AXG89_RS23540 | 129845..130252 | - | 408 | WP_062172844.1 | DUF2384 domain-containing protein | Antitoxin |
| AXG89_RS23545 | 130759..131064 | + | 306 | WP_062172847.1 | flagellar biosynthesis anti-sigma factor FlgM | - |
| AXG89_RS23550 | 131736..133286 | + | 1551 | WP_062172849.1 | methyl-accepting chemotaxis protein | - |
| AXG89_RS23555 | 133506..133769 | + | 264 | WP_162916116.1 | hypothetical protein | - |
| AXG89_RS23560 | 134053..134772 | + | 720 | WP_062172852.1 | IS4 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | katA | 1..793818 | 793818 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 174 a.a. Molecular weight: 19165.66 Da Isoelectric Point: 5.5882
>T60647 WP_062172842.1 NZ_CP014308:c129848-129327 [Burkholderia sp. PAMC 26561]
MIFANLSDVTVYRMLVPKWAVAPMSGAGAGTHGGRANRVGLNALYLGLDHDTAVREYQQLSSLMPPGTLVSYSLTAAPIV
DFTGGYESGKWSPLWEDFYCDWRHCWFNERIEPPSWIIGDEVVSSGAKGILFKSRLTPNGKNLVLYTENLDATDRLDVFD
PHNALPKNQSSWG
MIFANLSDVTVYRMLVPKWAVAPMSGAGAGTHGGRANRVGLNALYLGLDHDTAVREYQQLSSLMPPGTLVSYSLTAAPIV
DFTGGYESGKWSPLWEDFYCDWRHCWFNERIEPPSWIIGDEVVSSGAKGILFKSRLTPNGKNLVLYTENLDATDRLDVFD
PHNALPKNQSSWG
Download Length: 522 bp
>T60647 NZ_CP014308:c129848-129327 [Burkholderia sp. PAMC 26561]
ATGATTTTTGCGAACCTGTCCGACGTGACCGTATATCGGATGCTCGTCCCAAAGTGGGCAGTCGCGCCGATGAGCGGCGC
TGGAGCAGGAACGCATGGCGGTCGCGCGAATCGTGTCGGACTCAACGCGCTTTATCTGGGATTGGATCACGACACTGCCG
TCAGAGAGTATCAGCAACTCTCGTCCTTGATGCCACCAGGGACGCTGGTTAGCTACAGCCTCACGGCCGCCCCTATTGTC
GATTTCACCGGCGGATACGAGAGTGGCAAGTGGTCTCCTTTGTGGGAGGATTTTTATTGCGATTGGCGCCACTGCTGGTT
CAATGAACGGATCGAGCCACCAAGTTGGATCATCGGCGATGAGGTCGTCTCGAGCGGCGCCAAAGGCATCCTCTTCAAAT
CACGACTAACACCTAACGGCAAGAATCTCGTTCTGTACACAGAGAATTTGGACGCAACAGATCGTCTCGACGTTTTCGAT
CCGCACAATGCACTGCCGAAAAATCAGTCGTCGTGGGGTTGA
ATGATTTTTGCGAACCTGTCCGACGTGACCGTATATCGGATGCTCGTCCCAAAGTGGGCAGTCGCGCCGATGAGCGGCGC
TGGAGCAGGAACGCATGGCGGTCGCGCGAATCGTGTCGGACTCAACGCGCTTTATCTGGGATTGGATCACGACACTGCCG
TCAGAGAGTATCAGCAACTCTCGTCCTTGATGCCACCAGGGACGCTGGTTAGCTACAGCCTCACGGCCGCCCCTATTGTC
GATTTCACCGGCGGATACGAGAGTGGCAAGTGGTCTCCTTTGTGGGAGGATTTTTATTGCGATTGGCGCCACTGCTGGTT
CAATGAACGGATCGAGCCACCAAGTTGGATCATCGGCGATGAGGTCGTCTCGAGCGGCGCCAAAGGCATCCTCTTCAAAT
CACGACTAACACCTAACGGCAAGAATCTCGTTCTGTACACAGAGAATTTGGACGCAACAGATCGTCTCGACGTTTTCGAT
CCGCACAATGCACTGCCGAAAAATCAGTCGTCGTGGGGTTGA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14861.68 Da Isoelectric Point: 5.1774
>AT60647 WP_062172844.1 NZ_CP014308:c130252-129845 [Burkholderia sp. PAMC 26561]
MNLNADATVPGADIGFDRFMASLRDPDDPAPIVSARRFGEALHIDLQTLAQQAHVHRNTISRQPASESVQRFLRDALRVI
RAATDLAGDVSRALFWYRNEPLPVFDYKTAEQLVSEGRADDIIRFVASLEAGAAG
MNLNADATVPGADIGFDRFMASLRDPDDPAPIVSARRFGEALHIDLQTLAQQAHVHRNTISRQPASESVQRFLRDALRVI
RAATDLAGDVSRALFWYRNEPLPVFDYKTAEQLVSEGRADDIIRFVASLEAGAAG
Download Length: 408 bp
>AT60647 NZ_CP014308:c130252-129845 [Burkholderia sp. PAMC 26561]
ATGAACTTAAATGCAGATGCAACTGTTCCCGGCGCAGACATCGGCTTTGATCGATTTATGGCGTCGTTGCGTGACCCAGA
CGACCCCGCACCAATTGTGTCGGCCCGTCGATTCGGCGAGGCTTTGCATATTGACTTGCAAACCCTGGCGCAGCAAGCGC
ACGTGCACCGCAATACGATCAGCAGGCAACCTGCGTCCGAAAGCGTACAACGGTTTCTTCGTGACGCCCTAAGGGTGATC
CGCGCCGCGACTGATCTTGCAGGCGACGTCTCGAGGGCGCTTTTTTGGTACCGAAACGAACCCCTCCCGGTGTTCGACTA
TAAAACCGCCGAACAATTGGTGTCCGAAGGTCGGGCCGACGATATCATCCGTTTTGTTGCATCCCTCGAAGCGGGCGCGG
CGGGATGA
ATGAACTTAAATGCAGATGCAACTGTTCCCGGCGCAGACATCGGCTTTGATCGATTTATGGCGTCGTTGCGTGACCCAGA
CGACCCCGCACCAATTGTGTCGGCCCGTCGATTCGGCGAGGCTTTGCATATTGACTTGCAAACCCTGGCGCAGCAAGCGC
ACGTGCACCGCAATACGATCAGCAGGCAACCTGCGTCCGAAAGCGTACAACGGTTTCTTCGTGACGCCCTAAGGGTGATC
CGCGCCGCGACTGATCTTGCAGGCGACGTCTCGAGGGCGCTTTTTTGGTACCGAAACGAACCCCTCCCGGTGTTCGACTA
TAAAACCGCCGAACAATTGGTGTCCGAAGGTCGGGCCGACGATATCATCCGTTTTGTTGCATCCCTCGAAGCGGGCGCGG
CGGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0X8LAF1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0X8LAL5 |