Detailed information of TA system TA060640

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 239025..239614
• Replicon: chromosome
• Accession: NZ_CP014306
• Organism: Burkholderia sp. PAMC 26561

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A125SEZ2
• Locus tag: AXG89_RS01205
• Protein ID: WP_062167277.1
• Coordinates: 239222..239614 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: AXG89_RS01200
• Protein ID: WP_062167275.1
• Coordinates: 239025..239225 (+)
• Length: 67 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXG89_RS01175	234041..235021	-	981	WP_062167269.1	D-glycerate dehydrogenase	-
AXG89_RS01180	235032..236423	-	1392	WP_062167271.1	sodium:proton antiporter	-
AXG89_RS01185	236598..237788	-	1191	WP_062167273.1	nicotinate phosphoribosyltransferase	-
AXG89_RS01190	238234..238557	+	324	WP_061999968.1	ferredoxin family protein	-
AXG89_RS01200	239025..239225	+	201	WP_062167275.1	hypothetical protein	Antitoxin
AXG89_RS01205	239222..239614	+	393	WP_062167277.1	type II toxin-antitoxin system VapC family toxin	Toxin
AXG89_RS01210	239718..240461	+	744	WP_062167279.1	FadR family transcriptional regulator	-
AXG89_RS01215	240721..241638	+	918	WP_062167281.1	5-dehydro-4-deoxyglucarate dehydratase	-
AXG89_RS01220	241717..242304	-	588	WP_062167283.1	LUD domain-containing protein	-
AXG89_RS01225	242301..243710	-	1410	WP_061999974.1	lactate utilization protein	-
AXG89_RS01230	243707..244450	-	744	WP_061999975.1	(Fe-S)-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14499.36 Da
• Isoelectric Point: 6.7295

>T60640 WP_062167277.1 NZ_CP014306:239222-239614 [Burkholderia sp. PAMC 26561]
VNHLLDTNAVIALMKGNSGFLARLRQHRPRDFAISSIVAQELYYGAYKSQNAAENLKRVEALQFEVLDFDTEDARHAGEV
RVELALAGTPSGPYDALIAGQALARALTLVTRNTREFRRVSKLNVEDWES

Nucleotide

• Length: 393 bp

>T60640 NZ_CP014306:239222-239614 [Burkholderia sp. PAMC 26561]
GTGAACCACTTGCTCGACACGAACGCCGTCATTGCGCTCATGAAGGGAAATAGCGGATTTCTCGCTCGGCTGCGACAGCA
TCGACCGCGCGATTTCGCCATCTCATCCATCGTCGCACAAGAACTATATTACGGCGCATACAAGAGCCAGAACGCCGCCG
AGAACTTGAAGCGTGTTGAGGCGTTGCAATTCGAAGTTCTCGACTTCGATACTGAAGATGCCCGGCACGCAGGGGAAGTG
CGCGTGGAACTCGCATTGGCCGGAACTCCAAGTGGACCGTATGACGCTCTCATCGCGGGACAGGCCCTTGCCCGCGCACT
CACACTTGTCACTCGAAATACCCGGGAGTTCCGTCGCGTGAGCAAGCTGAACGTTGAGGACTGGGAAAGCTAG

Antitoxin

Protein

• Length: 67 a.a.
• Molecular weight: 7717.68 Da
• Isoelectric Point: 4.2813

>AT60640 WP_062167275.1 NZ_CP014306:239025-239225 [Burkholderia sp. PAMC 26561]
VRLPKEFRLDVDEVRVRRHGNAIILEPIANDWSWLELIVGPVDEGFIQASTEQPTEQDRPDLDFFK

Nucleotide

• Length: 201 bp

>AT60640 NZ_CP014306:239025-239225 [Burkholderia sp. PAMC 26561]
GTGCGCTTGCCCAAGGAGTTCCGACTGGACGTGGATGAAGTGCGTGTGCGGCGCCACGGCAACGCGATCATCCTCGAACC
GATCGCCAATGATTGGTCATGGCTCGAATTGATCGTCGGCCCCGTCGACGAAGGCTTTATCCAGGCATCAACTGAGCAGC
CGACCGAACAGGACCGCCCAGATCTGGATTTCTTTAAGTGA

Structures

Toxin

• AlphaFold DB: A0A125SEZ2