60639

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2256777..2257389 Replicon chromosome
Accession NZ_CP014304
Organism Hymenobacter sp. PAMC 26628

Toxin (Protein)


Gene name hicA Uniprot ID A0A126P9A7
Locus tag AXW84_RS09900 Protein ID WP_068232151.1
Coordinates 2256777..2257025 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A126P9A4
Locus tag AXW84_RS09905 Protein ID WP_068232154.1
Coordinates 2257048..2257389 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXW84_RS09875 2252310..2253011 - 702 WP_068232133.1 DUF421 domain-containing protein -
AXW84_RS09880 2253126..2253818 - 693 WP_068232135.1 DUF421 domain-containing protein -
AXW84_RS24755 2254190..2254366 - 177 WP_157886923.1 hypothetical protein -
AXW84_RS09885 2254382..2254594 - 213 WP_068232140.1 hypothetical protein -
AXW84_RS24760 2254809..2254952 + 144 WP_157886924.1 hypothetical protein -
AXW84_RS09890 2255000..2255359 + 360 WP_068232144.1 hypothetical protein -
AXW84_RS09895 2255493..2256647 - 1155 WP_068232147.1 hypothetical protein -
AXW84_RS09900 2256777..2257025 + 249 WP_068232151.1 type II toxin-antitoxin system HicA family toxin Toxin
AXW84_RS09905 2257048..2257389 + 342 WP_068232154.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AXW84_RS24765 2257393..2257863 + 471 WP_157886925.1 hypothetical protein -
AXW84_RS09910 2257999..2259912 + 1914 WP_071892637.1 AAA family ATPase -
AXW84_RS09915 2259985..2261007 - 1023 WP_082774110.1 SMP-30/gluconolactonase/LRE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(55-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9306.94 Da        Isoelectric Point: 9.9493

>T60639 WP_068232151.1 NZ_CP014304:2256777-2257025 [Hymenobacter sp. PAMC 26628]
MSQLDKLKARICAKPKDFTWDELVKLLTAYGFEALTKGKTAGSRRQFFNSTTQIAISLHKPHPDNILKEYQLKEIIALLG
IC

Download         Length: 249 bp

>T60639 NZ_CP014304:2256777-2257025 [Hymenobacter sp. PAMC 26628]
ATGTCCCAGCTTGACAAGCTCAAAGCCCGCATTTGTGCTAAGCCCAAAGATTTTACCTGGGACGAATTGGTAAAACTGCT
AACCGCCTACGGGTTCGAGGCGCTAACAAAAGGCAAAACGGCGGGCAGCCGGCGGCAGTTTTTTAATTCGACTACGCAAA
TTGCCATCAGCTTGCACAAGCCGCACCCTGACAATATTCTCAAAGAATACCAACTGAAAGAAATTATCGCGCTGCTCGGA
ATCTGCTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12147.75 Da        Isoelectric Point: 5.1131

>AT60639 WP_068232154.1 NZ_CP014304:2257048-2257389 [Hymenobacter sp. PAMC 26628]
MENGLLYKGYLGSVQYNAADEVFHGKIEAIADLVTFEADAAKQLRPEFEQAVDDYLALCAAVGKAPDKTFTGSFNVRLGP
ELHRKAALVSTGRGISLNQLVSQAVSQFVAKGE

Download         Length: 342 bp

>AT60639 NZ_CP014304:2257048-2257389 [Hymenobacter sp. PAMC 26628]
ATGGAAAACGGACTCCTCTACAAAGGCTACTTGGGCTCGGTGCAATACAACGCGGCCGATGAAGTATTTCACGGTAAAAT
CGAGGCCATCGCCGACTTAGTTACATTCGAGGCCGATGCTGCCAAGCAGCTCCGCCCCGAGTTTGAGCAGGCCGTGGACG
ACTACCTGGCCCTGTGCGCCGCCGTGGGCAAAGCACCCGACAAAACCTTTACCGGCAGCTTCAACGTGCGCCTGGGGCCC
GAACTGCACCGCAAAGCCGCGCTAGTGTCGACGGGCCGCGGCATCAGCCTGAACCAATTGGTAAGCCAGGCCGTGAGCCA
GTTCGTGGCGAAAGGCGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126P9A7

Antitoxin

Source ID Structure
AlphaFold DB A0A126P9A4

References