60638

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(antitoxin)
Location 217930..218507 Replicon chromosome
Accession NZ_CP014304
Organism Hymenobacter sp. PAMC 26628

Toxin (Protein)


Gene name mazF Uniprot ID A0A126P4Z6
Locus tag AXW84_RS01325 Protein ID WP_068227634.1
Coordinates 217930..218187 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A126P520
Locus tag AXW84_RS01330 Protein ID WP_068227637.1
Coordinates 218175..218507 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXW84_RS23830 214174..214854 + 681 Protein_192 DUF885 family protein -
AXW84_RS01300 215162..215425 + 264 WP_068227618.1 transposase -
AXW84_RS01305 215419..216162 + 744 Protein_194 IS3 family transposase -
AXW84_RS01310 216159..216824 - 666 WP_082773621.1 IS630 family transposase -
AXW84_RS01315 216815..217282 - 468 WP_068227630.1 helix-turn-helix domain-containing protein -
AXW84_RS22930 217328..217417 + 90 WP_082773622.1 integrase core domain-containing protein -
AXW84_RS01320 217486..217827 + 342 WP_157886744.1 hypothetical protein -
AXW84_RS01325 217930..218187 + 258 WP_068227634.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
AXW84_RS01330 218175..218507 + 333 WP_068227637.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
AXW84_RS01335 218518..219216 - 699 WP_068227641.1 IS5 family transposase -
AXW84_RS01340 219490..219786 + 297 WP_068227644.1 hypothetical protein -
AXW84_RS01345 219776..221023 + 1248 WP_071889735.1 DUF2157 domain-containing protein -
AXW84_RS01350 221064..221600 + 537 WP_068227650.1 GDYXXLXY domain-containing protein -
AXW84_RS01355 221831..222658 - 828 WP_082773624.1 energy transducer TonB -
AXW84_RS01360 222655..223182 - 528 WP_068227656.1 biopolymer transporter ExbD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

mRNA interferase PemK-like

(5-108)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9668.83 Da        Isoelectric Point: 4.3696

>T60638 WP_068227634.1 NZ_CP014304:217930-218187 [Hymenobacter sp. PAMC 26628]
MNTRLIRVGNSQGIVLPKKLLQQYHLTGEVDLQPTPEGLLITPVATPRRQDWDARFQHALAQGQAPEGELLEGFADDFDD
TEWQW

Download         Length: 258 bp

>T60638 NZ_CP014304:217930-218187 [Hymenobacter sp. PAMC 26628]
ATGAACACGCGCCTGATTCGGGTGGGCAATTCCCAGGGAATTGTGCTACCCAAGAAGCTCCTGCAACAGTACCACCTCAC
CGGCGAGGTCGACCTCCAGCCCACGCCGGAGGGCTTGCTCATCACGCCCGTGGCCACGCCCCGCCGCCAGGACTGGGACG
CGCGCTTTCAGCATGCCCTGGCCCAGGGCCAAGCCCCGGAGGGCGAGCTGCTGGAAGGCTTCGCCGACGACTTCGATGAC
ACGGAATGGCAGTGGTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12540.51 Da        Isoelectric Point: 9.2419

>AT60638 WP_068227637.1 NZ_CP014304:218175-218507 [Hymenobacter sp. PAMC 26628]
MAVVTVLRFEVWLVNLDPTQGSEINKTRPCVVLSPDEMNRYLRTVTVAALTSTRRDYPSRVDCTFQGKEGQVALDHIRSV
DKTRLVRRLGVLPKATAQAVCDRLQEMFQY

Download         Length: 333 bp

>AT60638 NZ_CP014304:218175-218507 [Hymenobacter sp. PAMC 26628]
ATGGCAGTGGTAACCGTGCTGCGCTTCGAGGTGTGGCTCGTCAACCTCGACCCCACACAGGGCAGCGAAATCAACAAGAC
CCGGCCCTGCGTGGTGCTCTCCCCCGACGAGATGAACCGCTACCTGCGCACGGTGACCGTGGCGGCGCTGACCAGCACCC
GGCGCGACTACCCTTCGCGCGTGGACTGCACGTTCCAGGGCAAAGAAGGCCAGGTGGCGCTCGACCACATCCGCTCCGTC
GACAAGACCCGCTTGGTGCGCCGCTTGGGCGTGCTGCCCAAAGCCACGGCCCAAGCCGTCTGCGACCGTTTACAGGAGAT
GTTTCAGTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126P4Z6

Antitoxin

Source ID Structure
AlphaFold DB A0A126P520

References