60636

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 4346067..4346604 Replicon chromosome
Accession NZ_CP014301
Organism Bosea sp. PAMC 26642 strain PAMC26642

Toxin (Protein)


Gene name parE Uniprot ID A0A126NZS3
Locus tag AXW83_RS20875 Protein ID WP_066616756.1
Coordinates 4346314..4346604 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A126NZU2
Locus tag AXW83_RS20870 Protein ID WP_066616753.1
Coordinates 4346067..4346324 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXW83_RS20845 (AXW83_20850) 4341462..4342277 + 816 WP_066616738.1 ABC transporter permease subunit -
AXW83_RS20850 (AXW83_20855) 4342300..4343175 - 876 WP_066616740.1 tetratricopeptide repeat protein -
AXW83_RS20855 (AXW83_20860) 4343369..4344676 + 1308 WP_082767537.1 leucyl aminopeptidase family protein -
AXW83_RS20860 (AXW83_20865) 4344758..4345111 + 354 WP_066616742.1 MarR family transcriptional regulator -
AXW83_RS20865 (AXW83_20870) 4345151..4346017 + 867 WP_066616750.1 C40 family peptidase -
AXW83_RS20870 (AXW83_20875) 4346067..4346324 + 258 WP_066616753.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
AXW83_RS20875 (AXW83_20880) 4346314..4346604 + 291 WP_066616756.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AXW83_RS20880 (AXW83_20885) 4346623..4349373 - 2751 WP_082767292.1 DNA mismatch repair protein MutS -
AXW83_RS20885 (AXW83_20890) 4349476..4351314 + 1839 WP_066616758.1 PAS domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11114.82 Da        Isoelectric Point: 6.0804

>T60636 WP_066616756.1 NZ_CP014301:4346314-4346604 [Bosea sp. PAMC 26642]
MPVKRTPQAEADLINIFLESAQRFGTKQAEIYAAKLSACFELLETMPSMARERLEISPPVRVHFHGSHVIVYAVEGDDIL
LLRVLHERRDWERELQ

Download         Length: 291 bp

>T60636 NZ_CP014301:4346314-4346604 [Bosea sp. PAMC 26642]
ATGCCGGTTAAGCGCACACCGCAAGCTGAAGCGGATCTGATTAATATCTTTCTTGAAAGCGCGCAGCGCTTCGGTACGAA
GCAGGCGGAGATTTATGCCGCCAAGCTGTCCGCGTGCTTCGAGCTATTGGAGACTATGCCTTCAATGGCGCGGGAGCGCC
TGGAAATCAGTCCGCCAGTTCGCGTCCATTTCCACGGCAGTCACGTGATTGTTTATGCTGTCGAGGGCGACGACATCCTG
CTTTTGCGTGTTCTCCACGAGCGTCGGGACTGGGAACGCGAGTTGCAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.88 Da        Isoelectric Point: 5.1953

>AT60636 WP_066616753.1 NZ_CP014301:4346067-4346324 [Bosea sp. PAMC 26642]
MATMNVSLPDQMKAWVEAQTETGRYGNASDYVRDLIRRDQERREKIAEFQRLVDEGRASGISTRTLDEVWDEARRRARAM
GLDAG

Download         Length: 258 bp

>AT60636 NZ_CP014301:4346067-4346324 [Bosea sp. PAMC 26642]
ATGGCGACCATGAACGTATCCCTGCCCGACCAGATGAAGGCCTGGGTCGAGGCCCAGACCGAGACGGGGCGGTACGGAAA
CGCCAGCGATTATGTGCGCGATCTGATTCGGCGGGATCAGGAGCGGCGGGAGAAGATCGCGGAATTCCAGCGCCTGGTCG
ATGAGGGGCGGGCCAGCGGGATCAGTACGCGAACGCTGGACGAGGTGTGGGACGAAGCCCGTCGCCGCGCGAGAGCCATG
GGTCTCGATGCCGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126NZS3

Antitoxin

Source ID Structure
AlphaFold DB A0A126NZU2

References