Detailed information of TA system TA060635

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 3955929..3956461
• Replicon: chromosome
• Accession: NZ_CP014301
• Organism: Bosea sp. PAMC 26642 strain PAMC26642

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AXW83_RS26685
• Protein ID: WP_082767243.1
• Coordinates: 3956177..3956461 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A126NYZ7
• Locus tag: AXW83_RS19050
• Protein ID: WP_066615948.1
• Coordinates: 3955929..3956180 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXW83_RS19025 (AXW83_19030)	3951721..3952002	+	282	WP_066615941.1	acyl carrier protein	-
AXW83_RS19030 (AXW83_19035)	3952211..3952684	+	474	WP_066615942.1	beta-hydroxyacyl-ACP dehydratase	-
AXW83_RS19035 (AXW83_19040)	3952681..3953811	+	1131	WP_066615943.1	beta-ketoacyl-ACP synthase	-
AXW83_RS19040 (AXW83_19045)	3953822..3955117	+	1296	WP_066615944.1	beta-ketoacyl-ACP synthase	-
AXW83_RS19045 (AXW83_19050)	3955114..3955860	+	747	WP_066615946.1	SDR family oxidoreductase	-
AXW83_RS19050 (AXW83_19055)	3955929..3956180	+	252	WP_066615948.1	CopG family ribbon-helix-helix protein	Antitoxin
AXW83_RS26685	3956177..3956461	+	285	WP_082767243.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AXW83_RS19060 (AXW83_19065)	3956476..3957498	+	1023	WP_066615952.1	zinc-binding dehydrogenase	-
AXW83_RS19065 (AXW83_19070)	3957650..3958585	+	936	WP_156640572.1	lipid A biosynthesis lauroyl acyltransferase	-
AXW83_RS19070 (AXW83_19075)	3958664..3959413	+	750	WP_066615953.1	DUF1223 domain-containing protein	-
AXW83_RS19075 (AXW83_19080)	3959418..3960023	-	606	WP_066615954.1	hypothetical protein	-
AXW83_RS19080 (AXW83_19085)	3960023..3960835	-	813	WP_066615955.1	TPM domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-41)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10507.03 Da
• Isoelectric Point: 8.5811

>T60635 WP_082767243.1 NZ_CP014301:3956177-3956461 [Bosea sp. PAMC 26642]
MKGIWTARARAELDEIADYLSAFGAATALDQVRRLRSAGRLLGEHPHKGRLGRVDESRELIVAGTPYILPYRVSDGRVEI
LAVIHTSRLWPDDL

Nucleotide

• Length: 285 bp

>T60635 NZ_CP014301:3956177-3956461 [Bosea sp. PAMC 26642]
ATGAAGGGCATATGGACCGCGCGGGCTCGAGCCGAACTTGATGAAATCGCCGATTATCTGAGCGCGTTCGGTGCCGCGAC
CGCATTGGACCAGGTGCGCCGCCTGCGGTCGGCAGGCAGACTGCTTGGAGAACACCCGCATAAGGGCCGGCTTGGCCGTG
TTGATGAAAGCCGTGAACTTATCGTAGCCGGCACCCCTTATATTCTTCCCTACCGTGTCAGCGATGGTCGCGTCGAAATC
CTTGCCGTGATCCATACGTCTAGGCTTTGGCCGGACGACCTCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9249.48 Da
• Isoelectric Point: 4.2917

>AT60635 WP_066615948.1 NZ_CP014301:3955929-3956180 [Bosea sp. PAMC 26642]
MTAAFTIRLDDEKLAKLDALAADMDRSRSWIAAKAIENYVELNAWQIARIKEGIAQADRGEFATEEELDAIEVKLQALID
AGR

Nucleotide

• Length: 252 bp

>AT60635 NZ_CP014301:3955929-3956180 [Bosea sp. PAMC 26642]
ATGACCGCAGCCTTCACCATTCGCCTCGACGACGAAAAGCTGGCCAAGCTCGATGCATTGGCCGCCGACATGGATCGCTC
GCGCAGCTGGATCGCCGCCAAGGCGATCGAGAATTATGTCGAACTCAACGCTTGGCAGATCGCACGCATCAAGGAAGGCA
TCGCTCAAGCCGATCGCGGTGAGTTCGCGACGGAAGAAGAGCTGGATGCTATCGAGGTCAAGCTTCAAGCATTGATCGAC
GCTGGCCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A126NYZ7