60634

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 3907890..3908482 Replicon chromosome
Accession NZ_CP014301
Organism Bosea sp. PAMC 26642 strain PAMC26642

Toxin (Protein)


Gene name PumA Uniprot ID A0A126NYT3
Locus tag AXW83_RS18820 Protein ID WP_066615890.1
Coordinates 3908177..3908482 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A126NZ28
Locus tag AXW83_RS18815 Protein ID WP_066615889.1
Coordinates 3907890..3908180 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXW83_RS18795 (AXW83_18800) 3903022..3904179 + 1158 WP_066615885.1 acyl-CoA dehydrogenase -
AXW83_RS18800 (AXW83_18805) 3904243..3906060 - 1818 WP_066615886.1 glucan ABC transporter ATP-binding protein/ permease -
AXW83_RS18805 (AXW83_18810) 3906204..3906974 + 771 WP_066615887.1 MotA/TolQ/ExbB proton channel family protein -
AXW83_RS18810 (AXW83_18815) 3907010..3907834 + 825 WP_066615888.1 flagellar motor protein MotB -
AXW83_RS18815 (AXW83_18820) 3907890..3908180 - 291 WP_066615889.1 putative addiction module antidote protein Antitoxin
AXW83_RS18820 (AXW83_18825) 3908177..3908482 - 306 WP_066615890.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AXW83_RS18825 (AXW83_18830) 3908518..3909042 - 525 WP_066615891.1 CAP domain-containing protein -
AXW83_RS18830 (AXW83_18835) 3909047..3911656 - 2610 WP_082767241.1 mechanosensitive ion channel family protein -
AXW83_RS18835 (AXW83_18840) 3911905..3912984 - 1080 WP_066615897.1 ROK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Uncharacterized protein HI1420

(8-89)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11414.15 Da        Isoelectric Point: 10.5986

>T60634 WP_066615890.1 NZ_CP014301:c3908482-3908177 [Bosea sp. PAMC 26642]
VIIVRRTQDFVQWLNGLRDLKAKARILTRLDRVAEGNVGDVKPVGEGISELRVDTGPGYRIYFTRFGRTVVILLCGGDKS
SQDRDIVRAKTIARSLKDEER

Download         Length: 306 bp

>T60634 NZ_CP014301:c3908482-3908177 [Bosea sp. PAMC 26642]
GTGATCATCGTTCGGCGGACCCAGGATTTCGTGCAGTGGCTCAACGGGCTACGCGATCTGAAAGCCAAGGCTCGGATCCT
GACGCGGCTCGATCGTGTCGCGGAGGGCAATGTCGGCGATGTAAAGCCGGTTGGTGAGGGCATCAGCGAGCTGCGGGTCG
ATACCGGGCCCGGCTATCGCATTTACTTCACCCGTTTCGGTCGAACCGTCGTCATTCTGCTATGTGGTGGCGACAAGAGC
AGCCAAGATCGCGACATCGTCAGGGCCAAGACGATCGCGCGGTCGCTAAAGGACGAAGAGCGATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10242.65 Da        Isoelectric Point: 4.3696

>AT60634 WP_066615889.1 NZ_CP014301:c3908180-3907890 [Bosea sp. PAMC 26642]
MTIDVGPWDTSEHLDTPEMISAYLDAALEDGDPALFSRALGNVARAIGMTQIARDTGLSREALYRALSAEGNPEFGTVLK
VMHAFGLRLAPVPLSA

Download         Length: 291 bp

>AT60634 NZ_CP014301:c3908180-3907890 [Bosea sp. PAMC 26642]
ATGACGATCGACGTCGGGCCTTGGGATACCTCGGAGCATCTCGATACGCCGGAAATGATCTCGGCTTATCTAGATGCCGC
CTTGGAGGATGGCGACCCTGCGTTGTTCTCGCGCGCGCTCGGCAATGTCGCGCGTGCGATCGGGATGACCCAGATCGCGC
GGGATACCGGTCTCAGTCGGGAGGCGCTCTATCGGGCGTTGAGCGCCGAGGGCAACCCCGAGTTCGGCACGGTTCTCAAG
GTCATGCACGCCTTCGGCCTGCGCCTTGCGCCGGTGCCGCTGAGTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126NYT3

Antitoxin

Source ID Structure
AlphaFold DB A0A126NZ28

References