Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3627148..3627716 Replicon chromosome
Accession NZ_CP014301
Organism Bosea sp. PAMC 26642 strain PAMC26642

Toxin (Protein)


Gene name vapC Uniprot ID A0A126NYV3
Locus tag AXW83_RS17440 Protein ID WP_066615469.1
Coordinates 3627148..3627522 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A126NYF1
Locus tag AXW83_RS17445 Protein ID WP_066615471.1
Coordinates 3627519..3627716 (-) Length 66 a.a.

Genomic Context

AXW83_RS17415AXW83_RS17430AXW83_RS17435AXW83_RS27655AXW83_RS17420AXW83_RS17425AXW83_RS17440AXW83_RS17445AXW83_RS17450AXW83_RS17460
Location: 3622616..3623770 (1155 bp)
Type: Others
Protein ID: WP_066615463.1
Location: 3625267..3625746 (480 bp)
Type: Others
Protein ID: WP_066620695.1
Location: 3625844..3627139 (1296 bp)
Type: Others
Protein ID: WP_066615467.1
Location: 3630233..3631246 (1014 bp)
Type: Others
Protein ID: WP_210179715.1
Location: 3623878..3624468 (591 bp)
Type: Others
Protein ID: WP_082767204.1
Location: 3624561..3625082 (522 bp)
Type: Others
Protein ID: WP_066615465.1
Location: 3627148..3627522 (375 bp)
Type: Toxin
Protein ID: WP_066615469.1
Location: 3627519..3627716 (198 bp)
Type: Antitoxin
Protein ID: WP_066615471.1
Location: 3627789..3629411 (1623 bp)
Type: Others
Protein ID: WP_066615473.1
Location: 3631253..3632014 (762 bp)
Type: Others
Protein ID: WP_066620702.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AXW83_RS17415 (AXW83_17420)3622616..3623770+1155WP_066615463.1aminotransferase class V-fold PLP-dependent enzyme-
AXW83_RS17420 (AXW83_17425)3623878..3624468-591WP_082767204.1hypothetical protein-
AXW83_RS17425 (AXW83_17430)3624561..3625082-522WP_066615465.1cysteine dioxygenase family protein-
AXW83_RS17430 (AXW83_17435)3625267..3625746+480WP_066620695.1Lrp/AsnC family transcriptional regulator-
AXW83_RS17435 (AXW83_17440)3625844..3627139+1296WP_066615467.1aminotransferase class V-fold PLP-dependent enzyme-
AXW83_RS17440 (AXW83_17445)3627148..3627522-375WP_066615469.1type II toxin-antitoxin system VapC family toxinToxin
AXW83_RS17445 (AXW83_17450)3627519..3627716-198WP_066615471.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
AXW83_RS17450 (AXW83_17455)3627789..3629411-1623WP_066615473.1peptide chain release factor 3-
AXW83_RS276553630233..3631246+1014WP_210179715.1hypothetical protein-
AXW83_RS17460 (AXW83_17465)3631253..3632014-762WP_066620702.1ABC transporter permease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13771.14 Da        Isoelectric Point: 9.8820

>T60633 WP_066615469.1 NZ_CP014301:c3627522-3627148 [Bosea sp. PAMC 26642]
VILLDASVWIDHLRRREPRLEQLLSDRRVLMHPFVVAEVALGSIARRAAMIGLLESFPQAAVATHEEVLALIEGKKLYGL
GIGYVDVHLLASARLADARLWTRDRRLRAAADLLRLSAPFDLGG

Download         Length: 375 bp

>T60633 NZ_CP014301:c3627522-3627148 [Bosea sp. PAMC 26642]
GTGATCCTGCTTGATGCCTCGGTCTGGATCGACCACCTGCGCCGTCGCGAGCCACGCCTTGAGCAACTTCTGTCCGATCG
GCGAGTGCTCATGCACCCGTTTGTCGTCGCGGAAGTGGCGCTCGGCTCGATAGCCCGCCGCGCTGCCATGATCGGGCTGC
TGGAGAGTTTCCCACAGGCGGCAGTCGCCACGCATGAGGAAGTCTTGGCGCTGATCGAGGGCAAAAAACTCTATGGTCTC
GGCATCGGCTACGTCGATGTGCATCTTCTGGCGTCGGCTCGACTTGCCGACGCTCGGCTCTGGACGCGCGATCGGCGACT
GCGCGCCGCCGCCGATCTTTTGAGGTTGTCAGCCCCCTTCGATCTCGGCGGCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7155.27 Da        Isoelectric Point: 10.5916

>AT60633 WP_066615471.1 NZ_CP014301:c3627716-3627519 [Bosea sp. PAMC 26642]
MRTTVTLDDKLVEQAQFYTGITERSALLREALTALVQREAMKRAIKLGGTDPDATAAPRRRLPAA

Download         Length: 198 bp

>AT60633 NZ_CP014301:c3627716-3627519 [Bosea sp. PAMC 26642]
ATGCGCACGACCGTGACACTGGACGACAAGCTCGTCGAACAGGCGCAGTTCTACACGGGGATCACTGAGCGCTCGGCATT
GCTGCGCGAAGCGCTGACAGCCCTGGTCCAGCGCGAAGCGATGAAGCGCGCTATCAAACTCGGCGGCACCGATCCCGACG
CGACAGCCGCACCGCGCAGGCGTCTGCCCGCAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A126NYV3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A126NYF1

References