60633

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3627148..3627716 Replicon chromosome
Accession NZ_CP014301
Organism Bosea sp. PAMC 26642 strain PAMC26642

Toxin (Protein)


Gene name vapC Uniprot ID A0A126NYV3
Locus tag AXW83_RS17440 Protein ID WP_066615469.1
Coordinates 3627148..3627522 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A126NYF1
Locus tag AXW83_RS17445 Protein ID WP_066615471.1
Coordinates 3627519..3627716 (-) Length 66 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXW83_RS17415 (AXW83_17420) 3622616..3623770 + 1155 WP_066615463.1 aminotransferase class V-fold PLP-dependent enzyme -
AXW83_RS17420 (AXW83_17425) 3623878..3624468 - 591 WP_082767204.1 hypothetical protein -
AXW83_RS17425 (AXW83_17430) 3624561..3625082 - 522 WP_066615465.1 cysteine dioxygenase family protein -
AXW83_RS17430 (AXW83_17435) 3625267..3625746 + 480 WP_066620695.1 Lrp/AsnC family transcriptional regulator -
AXW83_RS17435 (AXW83_17440) 3625844..3627139 + 1296 WP_066615467.1 aminotransferase class V-fold PLP-dependent enzyme -
AXW83_RS17440 (AXW83_17445) 3627148..3627522 - 375 WP_066615469.1 type II toxin-antitoxin system VapC family toxin Toxin
AXW83_RS17445 (AXW83_17450) 3627519..3627716 - 198 WP_066615471.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
AXW83_RS17450 (AXW83_17455) 3627789..3629411 - 1623 WP_066615473.1 peptide chain release factor 3 -
AXW83_RS27655 3630233..3631246 + 1014 WP_210179715.1 hypothetical protein -
AXW83_RS17460 (AXW83_17465) 3631253..3632014 - 762 WP_066620702.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-111)

Antitoxin

(1-43)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13771.14 Da        Isoelectric Point: 9.8820

>T60633 WP_066615469.1 NZ_CP014301:c3627522-3627148 [Bosea sp. PAMC 26642]
VILLDASVWIDHLRRREPRLEQLLSDRRVLMHPFVVAEVALGSIARRAAMIGLLESFPQAAVATHEEVLALIEGKKLYGL
GIGYVDVHLLASARLADARLWTRDRRLRAAADLLRLSAPFDLGG

Download         Length: 375 bp

>T60633 NZ_CP014301:c3627522-3627148 [Bosea sp. PAMC 26642]
GTGATCCTGCTTGATGCCTCGGTCTGGATCGACCACCTGCGCCGTCGCGAGCCACGCCTTGAGCAACTTCTGTCCGATCG
GCGAGTGCTCATGCACCCGTTTGTCGTCGCGGAAGTGGCGCTCGGCTCGATAGCCCGCCGCGCTGCCATGATCGGGCTGC
TGGAGAGTTTCCCACAGGCGGCAGTCGCCACGCATGAGGAAGTCTTGGCGCTGATCGAGGGCAAAAAACTCTATGGTCTC
GGCATCGGCTACGTCGATGTGCATCTTCTGGCGTCGGCTCGACTTGCCGACGCTCGGCTCTGGACGCGCGATCGGCGACT
GCGCGCCGCCGCCGATCTTTTGAGGTTGTCAGCCCCCTTCGATCTCGGCGGCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7155.27 Da        Isoelectric Point: 10.5916

>AT60633 WP_066615471.1 NZ_CP014301:c3627716-3627519 [Bosea sp. PAMC 26642]
MRTTVTLDDKLVEQAQFYTGITERSALLREALTALVQREAMKRAIKLGGTDPDATAAPRRRLPAA

Download         Length: 198 bp

>AT60633 NZ_CP014301:c3627716-3627519 [Bosea sp. PAMC 26642]
ATGCGCACGACCGTGACACTGGACGACAAGCTCGTCGAACAGGCGCAGTTCTACACGGGGATCACTGAGCGCTCGGCATT
GCTGCGCGAAGCGCTGACAGCCCTGGTCCAGCGCGAAGCGATGAAGCGCGCTATCAAACTCGGCGGCACCGATCCCGACG
CGACAGCCGCACCGCGCAGGCGTCTGCCCGCAGCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A126NYV3


Antitoxin

Source ID Structure
AlphaFold DB A0A126NYF1

References