60631

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2398685..2399340 Replicon chromosome
Accession NZ_CP014301
Organism Bosea sp. PAMC 26642 strain PAMC26642

Toxin (Protein)


Gene name vapC Uniprot ID A0A126NV16
Locus tag AXW83_RS11460 Protein ID WP_066613570.1
Coordinates 2398921..2399340 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A126NVI8
Locus tag AXW83_RS11455 Protein ID WP_066613566.1
Coordinates 2398685..2398924 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXW83_RS11420 (AXW83_11425) 2393846..2394475 - 630 WP_066613549.1 2-hydroxychromene-2-carboxylate isomerase -
AXW83_RS11425 (AXW83_11430) 2394650..2394934 - 285 WP_066613551.1 hypothetical protein -
AXW83_RS11430 (AXW83_11435) 2395129..2395377 + 249 WP_066613552.1 type II toxin-antitoxin system ParD family antitoxin -
AXW83_RS11435 (AXW83_11440) 2395374..2395670 + 297 WP_066613558.1 type II toxin-antitoxin system RelE/ParE family toxin -
AXW83_RS11440 (AXW83_11445) 2395676..2396440 - 765 WP_066613560.1 peptidoglycan editing factor PgeF -
AXW83_RS11445 (AXW83_11450) 2396491..2397639 - 1149 WP_210179697.1 SAM-dependent methyltransferase -
AXW83_RS11450 (AXW83_11455) 2397705..2398541 - 837 WP_066613564.1 prolipoprotein diacylglyceryl transferase -
AXW83_RS11455 (AXW83_11460) 2398685..2398924 + 240 WP_066613566.1 plasmid stability protein Antitoxin
AXW83_RS11460 (AXW83_11465) 2398921..2399340 + 420 WP_066613570.1 type II toxin-antitoxin system VapC family toxin Toxin
AXW83_RS11465 (AXW83_11470) 2399372..2399938 - 567 WP_066620342.1 chloramphenicol phosphotransferase -
AXW83_RS11470 (AXW83_11475) 2400018..2402219 + 2202 WP_066613573.1 excinuclease ABC subunit UvrC -
AXW83_RS11475 (AXW83_11480) 2402304..2402915 + 612 WP_066620345.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
AXW83_RS11480 (AXW83_11485) 2402912..2403193 + 282 WP_066613576.1 molybdopterin converting factor subunit 1 -
AXW83_RS11485 (AXW83_11490) 2403344..2403796 + 453 WP_066620348.1 molybdenum cofactor biosynthesis protein MoaE -
AXW83_RS11490 (AXW83_11495) 2403871..2404128 + 258 WP_066613578.1 type II toxin-antitoxin system prevent-host-death family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14964.20 Da        Isoelectric Point: 6.0845

>T60631 WP_066613570.1 NZ_CP014301:2398921-2399340 [Bosea sp. PAMC 26642]
VILLDTNVVSEASKPVGHPDVRAWLDAQIAETLYLSAITVAELLFGIAILPEGRRKRALEDNLRRVVLPVFEGRILHFDA
AAAEAYARIRAHGRATGKAIETVDGYIAAIAEAHQLTVATRDTGPFIAAGLTVIDPWTA

Download         Length: 420 bp

>T60631 NZ_CP014301:2398921-2399340 [Bosea sp. PAMC 26642]
GTGATTCTGCTGGACACCAATGTGGTGTCGGAAGCCTCAAAGCCCGTCGGGCATCCAGACGTCAGGGCGTGGCTCGACGC
CCAAATCGCCGAGACTTTGTATTTGTCGGCGATAACCGTTGCCGAGCTTTTGTTCGGCATTGCCATCTTGCCGGAAGGCC
GCCGCAAGCGCGCGCTCGAAGACAATTTGCGTCGCGTCGTCTTGCCGGTCTTCGAGGGGCGTATACTGCATTTCGATGCT
GCGGCAGCCGAAGCCTATGCGCGTATTCGCGCACACGGCAGGGCAACAGGCAAAGCCATCGAGACGGTCGATGGTTACAT
TGCAGCTATAGCAGAGGCTCACCAACTGACTGTGGCGACGCGCGACACCGGCCCGTTCATCGCAGCCGGCCTGACGGTTA
TCGACCCCTGGACGGCATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8590.72 Da        Isoelectric Point: 8.8639

>AT60631 WP_066613566.1 NZ_CP014301:2398685-2398924 [Bosea sp. PAMC 26642]
MASVTVRKISDETHRALKARATHHGRSTEAEIRHIIEAAVNPPGRIKLGSLLAKIGQETGGFETDGLRDKTISEPVSFE

Download         Length: 240 bp

>AT60631 NZ_CP014301:2398685-2398924 [Bosea sp. PAMC 26642]
ATGGCTTCAGTCACCGTTCGAAAGATTTCCGACGAGACGCATCGGGCTCTCAAGGCCCGCGCGACACATCATGGCCGCAG
CACCGAAGCCGAGATCCGACACATCATCGAGGCTGCGGTGAATCCGCCTGGCCGCATCAAGCTAGGTTCGCTGTTAGCGA
AGATCGGGCAGGAAACTGGTGGTTTTGAAACAGATGGTCTTCGAGACAAAACGATTTCCGAGCCGGTGAGTTTCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126NV16

Antitoxin

Source ID Structure
AlphaFold DB A0A126NVI8

References