Detailed information of TA system TA060624

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relE/YoeB-YefM
• Location: 17171..17727
• Replicon: chromosome
• Accession: NZ_CP014301
• Organism: Bosea sp. PAMC 26642 strain PAMC26642

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A126NPQ8
• Locus tag: AXW83_RS00075
• Protein ID: WP_066609568.1
• Coordinates: 17473..17727 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AXW83_RS00070
• Protein ID: WP_066609567.1
• Coordinates: 17171..17476 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXW83_RS00055 (AXW83_00055)	13179..14387	+	1209	WP_066609562.1	acetyl-CoA C-acetyltransferase	-
AXW83_RS00060 (AXW83_00060)	14399..16603	+	2205	WP_066609564.1	enoyl-CoA hydratase/isomerase family protein	-
AXW83_RS00065 (AXW83_00065)	16611..17105	+	495	WP_066609566.1	peptide deformylase	-
AXW83_RS00070 (AXW83_00070)	17171..17476	+	306	WP_066609567.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
AXW83_RS00075 (AXW83_00075)	17473..17727	+	255	WP_066609568.1	Txe/YoeB family addiction module toxin	Toxin
AXW83_RS00080 (AXW83_00080)	17739..18758	-	1020	WP_156639639.1	serine hydrolase	-
AXW83_RS00085 (AXW83_00085)	18863..20203	-	1341	WP_066609569.1	aspartate aminotransferase family protein	-
AXW83_RS00090 (AXW83_00090)	20388..22187	+	1800	WP_066609570.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9839.41 Da
• Isoelectric Point: 10.0496

>T60624 WP_066609568.1 NZ_CP014301:17473-17727 [Bosea sp. PAMC 26642]
MNVVLSRRAMAELVALAAHEPKSALKALQLIDECTRTPFTGRGKPEPLRHDKAGWRSRRITDEHRLVYRVIEDRLEIVQC
RYHY

Nucleotide

• Length: 255 bp

>T60624 NZ_CP014301:17473-17727 [Bosea sp. PAMC 26642]
ATGAACGTCGTCTTGTCGCGCCGAGCTATGGCTGAGCTGGTCGCCCTGGCGGCTCATGAGCCGAAATCAGCTTTGAAGGC
GCTGCAACTCATCGACGAATGTACGCGCACGCCCTTTACCGGCCGCGGCAAACCCGAACCGCTGAGGCATGACAAGGCAG
GCTGGCGGTCCCGCCGTATCACCGACGAACACCGTCTGGTCTATCGCGTGATCGAGGACAGGCTCGAAATCGTCCAGTGC
CGCTATCATTATTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 10931.10 Da
• Isoelectric Point: 4.2392

>AT60624 WP_066609567.1 NZ_CP014301:17171-17476 [Bosea sp. PAMC 26642]
MKVVTYSHLRANLAKIMDQAADDHDPVIVTRSNGKTAVLMSLEDFGSYETTRYLNASPANAKALEESIAELDRGEGITFG
SIEELEASVANALSERQDAAE

Nucleotide

• Length: 306 bp

>AT60624 NZ_CP014301:17171-17476 [Bosea sp. PAMC 26642]
ATGAAAGTCGTGACCTACTCCCATCTGCGCGCCAACCTCGCCAAGATCATGGATCAGGCGGCGGACGATCATGATCCGGT
GATCGTCACGCGATCGAACGGCAAGACAGCCGTGCTGATGTCGCTGGAGGATTTTGGCTCCTATGAGACGACGCGCTATC
TAAACGCCAGCCCGGCGAATGCGAAGGCGCTCGAGGAGTCGATCGCCGAGTTGGATCGTGGTGAGGGTATTACCTTCGGC
TCGATCGAGGAACTGGAAGCCTCGGTTGCGAATGCCTTGTCAGAGCGACAAGACGCTGCAGAATGA

Structures

Toxin

• AlphaFold DB: A0A126NPQ8