Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2311235..2312213 Replicon chromosome
Accession NZ_CP014282
Organism Bacillus thuringiensis strain Bt185

Toxin (Protein)


Gene name spoIISA Uniprot ID M1Q940
Locus tag AXW78_RS11780 Protein ID WP_000624982.1
Coordinates 2311235..2311972 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag AXW78_RS11785 Protein ID WP_046946297.1
Coordinates 2312085..2312213 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXW78_RS33805 2306321..2306597 + 277 Protein_2265 transposase -
AXW78_RS11750 2306720..2307430 + 711 WP_000787493.1 class I SAM-dependent methyltransferase -
AXW78_RS11755 2307546..2307953 + 408 WP_000063589.1 VOC family protein -
AXW78_RS11760 2307975..2308355 + 381 WP_000497668.1 methyltransferase -
AXW78_RS11765 2308513..2309370 - 858 Protein_2269 alpha-keto acid decarboxylase family protein -
AXW78_RS11770 2309610..2310092 + 483 WP_000191914.1 MarR family winged helix-turn-helix transcriptional regulator -
AXW78_RS11775 2310259..2310996 + 738 WP_000594147.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
AXW78_RS11780 2311235..2311972 + 738 WP_000624982.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
AXW78_RS11785 2312085..2312213 + 129 WP_046946297.1 hypothetical protein Antitoxin
AXW78_RS11790 2312286..2312462 + 177 WP_000852629.1 stage II sporulation protein SB -
AXW78_RS11795 2312482..2312871 - 390 WP_000714181.1 YxeA family protein -
AXW78_RS11800 2313083..2314552 + 1470 WP_061884163.1 beta-Ala-His dipeptidase -
AXW78_RS11805 2314798..2315607 + 810 WP_000678378.1 C39 family peptidase -
AXW78_RS11810 2315633..2316235 + 603 WP_000517278.1 hypothetical protein -
AXW78_RS11815 2316477..2316728 - 252 WP_000827560.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28323.03 Da        Isoelectric Point: 8.2998

>T60623 WP_000624982.1 NZ_CP014282:2311235-2311972 [Bacillus thuringiensis]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPSVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T60623 NZ_CP014282:2311235-2311972 [Bacillus thuringiensis]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTTTGGAAGAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCATTC
ATTTTAACACCTAATATTTCAGAAATATGGGGTGCCAAATTTAGCGATATTGGCAAGACAGTTCAATCAATCAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACGACAATTATTCAAAATGTTAATCCATCAGTTTTCGGTACGATGG
AATGGCATACGGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATACGGGGAAAAGATTGGCGCGAAAATT
GTTGTTTTTGAAGCCGCGAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCGGTACAAGTAGAAAATGTCGGGATCATACCAGCAAAAATAGTAAGTGACG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4952.37 Da        Isoelectric Point: 4.0548

>AT60623 WP_046946297.1 NZ_CP014282:2312085-2312213 [Bacillus thuringiensis]
VVKNYDNDFFKEGNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp

>AT60623 NZ_CP014282:2312085-2312213 [Bacillus thuringiensis]
GTGGTAAAAAATTATGACAATGATTTTTTTAAAGAAGGTAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M1Q940

Antitoxin

Source ID Structure

References