Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2311235..2312213 | Replicon | chromosome |
| Accession | NZ_CP014282 | ||
| Organism | Bacillus thuringiensis strain Bt185 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | M1Q940 |
| Locus tag | AXW78_RS11780 | Protein ID | WP_000624982.1 |
| Coordinates | 2311235..2311972 (+) | Length | 246 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | AXW78_RS11785 | Protein ID | WP_046946297.1 |
| Coordinates | 2312085..2312213 (+) | Length | 43 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AXW78_RS33805 | 2306321..2306597 | + | 277 | Protein_2265 | transposase | - |
| AXW78_RS11750 | 2306720..2307430 | + | 711 | WP_000787493.1 | class I SAM-dependent methyltransferase | - |
| AXW78_RS11755 | 2307546..2307953 | + | 408 | WP_000063589.1 | VOC family protein | - |
| AXW78_RS11760 | 2307975..2308355 | + | 381 | WP_000497668.1 | methyltransferase | - |
| AXW78_RS11765 | 2308513..2309370 | - | 858 | Protein_2269 | alpha-keto acid decarboxylase family protein | - |
| AXW78_RS11770 | 2309610..2310092 | + | 483 | WP_000191914.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| AXW78_RS11775 | 2310259..2310996 | + | 738 | WP_000594147.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| AXW78_RS11780 | 2311235..2311972 | + | 738 | WP_000624982.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| AXW78_RS11785 | 2312085..2312213 | + | 129 | WP_046946297.1 | hypothetical protein | Antitoxin |
| AXW78_RS11790 | 2312286..2312462 | + | 177 | WP_000852629.1 | stage II sporulation protein SB | - |
| AXW78_RS11795 | 2312482..2312871 | - | 390 | WP_000714181.1 | YxeA family protein | - |
| AXW78_RS11800 | 2313083..2314552 | + | 1470 | WP_061884163.1 | beta-Ala-His dipeptidase | - |
| AXW78_RS11805 | 2314798..2315607 | + | 810 | WP_000678378.1 | C39 family peptidase | - |
| AXW78_RS11810 | 2315633..2316235 | + | 603 | WP_000517278.1 | hypothetical protein | - |
| AXW78_RS11815 | 2316477..2316728 | - | 252 | WP_000827560.1 | response regulator transcription factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28323.03 Da Isoelectric Point: 8.2998
>T60623 WP_000624982.1 NZ_CP014282:2311235-2311972 [Bacillus thuringiensis]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPSVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPSVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T60623 NZ_CP014282:2311235-2311972 [Bacillus thuringiensis]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTTTGGAAGAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCATTC
ATTTTAACACCTAATATTTCAGAAATATGGGGTGCCAAATTTAGCGATATTGGCAAGACAGTTCAATCAATCAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACGACAATTATTCAAAATGTTAATCCATCAGTTTTCGGTACGATGG
AATGGCATACGGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATACGGGGAAAAGATTGGCGCGAAAATT
GTTGTTTTTGAAGCCGCGAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCGGTACAAGTAGAAAATGTCGGGATCATACCAGCAAAAATAGTAAGTGACG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTTTGGAAGAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCATTC
ATTTTAACACCTAATATTTCAGAAATATGGGGTGCCAAATTTAGCGATATTGGCAAGACAGTTCAATCAATCAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACGACAATTATTCAAAATGTTAATCCATCAGTTTTCGGTACGATGG
AATGGCATACGGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATACGGGGAAAAGATTGGCGCGAAAATT
GTTGTTTTTGAAGCCGCGAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCGGTACAAGTAGAAAATGTCGGGATCATACCAGCAAAAATAGTAAGTGACG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
Antitoxin
Download Length: 43 a.a. Molecular weight: 4952.37 Da Isoelectric Point: 4.0548
>AT60623 WP_046946297.1 NZ_CP014282:2312085-2312213 [Bacillus thuringiensis]
VVKNYDNDFFKEGNEDTTDFSLIKGDTLQQVEELEEELKRKS
VVKNYDNDFFKEGNEDTTDFSLIKGDTLQQVEELEEELKRKS
Download Length: 129 bp
>AT60623 NZ_CP014282:2312085-2312213 [Bacillus thuringiensis]
GTGGTAAAAAATTATGACAATGATTTTTTTAAAGAAGGTAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA
GTGGTAAAAAATTATGACAATGATTTTTTTAAAGAAGGTAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|