Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4043718..4044531 Replicon chromosome
Accession NZ_CP014275
Organism Martelella sp. AD-3

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A127CMP2
Locus tag AZF01_RS18640 Protein ID WP_024707725.1
Coordinates 4043718..4044227 (-) Length 170 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A7W8HVE4
Locus tag AZF01_RS18645 Protein ID WP_024707726.1
Coordinates 4044232..4044531 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AZF01_RS18625 4039209..4040531 + 1323 WP_024707722.1 SIR2 family protein -
AZF01_RS18630 4040528..4042552 + 2025 WP_024707723.1 ATP-binding protein -
AZF01_RS18635 4042539..4043432 + 894 WP_024707724.1 3'-5' exonuclease -
AZF01_RS18640 4043718..4044227 - 510 WP_024707725.1 GNAT family N-acetyltransferase Toxin
AZF01_RS18645 4044232..4044531 - 300 WP_024707726.1 DUF1778 domain-containing protein Antitoxin
AZF01_RS18650 4044801..4045025 + 225 WP_036236851.1 hypothetical protein -
AZF01_RS18655 4045045..4046697 + 1653 WP_081725751.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(40-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-92)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 17828.52 Da        Isoelectric Point: 8.2916

>T60620 WP_024707725.1 NZ_CP014275:c4044227-4043718 [Martelella sp. AD-3]
MLLSGPEPLSAAHDVSEFTCGNPTLDRWLKTRALSNQQKGFTAVLVVHEAGRVVGYYGLAPTAVVPSVLPRSIRTGQPPN
PIPCMLLGQLATDIGSAGLGIGTGLVKHALQRCVQAASLIGGRALMVNAVDGEAAEFWQRRGFEPARDDGLVLFRSISDI
AASLREAGR

Download         Length: 510 bp

>T60620 NZ_CP014275:c4044227-4043718 [Martelella sp. AD-3]
TTGCTGCTTTCAGGACCCGAGCCGCTTTCCGCCGCCCACGATGTTTCTGAGTTTACCTGTGGCAATCCGACGCTCGACCG
CTGGCTGAAAACCCGCGCGCTCTCCAATCAGCAGAAGGGCTTTACCGCCGTTCTCGTCGTGCATGAGGCAGGGCGTGTGG
TGGGTTATTACGGCCTTGCACCAACAGCCGTTGTGCCATCGGTGCTACCGCGCTCCATCCGGACGGGGCAGCCCCCTAAT
CCAATTCCCTGCATGCTGCTTGGCCAGCTCGCGACCGATATCGGCTCGGCAGGGTTGGGCATCGGGACTGGCCTTGTGAA
GCACGCCCTCCAACGCTGCGTTCAGGCCGCATCGCTGATCGGTGGGCGGGCATTGATGGTCAACGCCGTCGACGGGGAGG
CTGCCGAATTCTGGCAGCGTCGAGGATTTGAGCCTGCCAGAGATGATGGACTGGTCCTGTTTCGCTCGATCAGCGATATT
GCTGCGTCGCTCCGTGAGGCTGGAAGGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11060.78 Da        Isoelectric Point: 6.3779

>AT60620 WP_024707726.1 NZ_CP014275:c4044531-4044232 [Martelella sp. AD-3]
MANTAERKEYPISMRLPEADVAMIDRAASLRGRSRTDFVRDAAVRAAEEVVMEQGLIRMSPEGFAQFMDVLSRPAAPVPE
MVEVLKRPAPWEPGYAAKR

Download         Length: 300 bp

>AT60620 NZ_CP014275:c4044531-4044232 [Martelella sp. AD-3]
ATGGCCAACACTGCCGAACGCAAGGAATATCCTATCTCAATGCGTCTGCCCGAGGCCGATGTTGCCATGATCGATCGTGC
CGCCAGCCTGCGCGGCCGTTCGCGCACCGATTTCGTGCGAGATGCCGCTGTGCGCGCGGCCGAGGAGGTCGTCATGGAGC
AGGGCCTGATCCGGATGAGCCCGGAAGGCTTTGCTCAGTTCATGGATGTGCTGTCGCGCCCGGCCGCTCCTGTTCCGGAG
ATGGTTGAAGTGCTGAAGCGGCCTGCGCCGTGGGAGCCCGGCTACGCGGCGAAGCGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127CMP2

Antitoxin

Source ID Structure
AlphaFold DB A0A7W8HVE4

References