Detailed information of TA system TA060619

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/couple_hipB(antitoxin)
• Location: 2382265..2382867
• Replicon: chromosome
• Accession: NZ_CP014275
• Organism: Martelella sp. AD-3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AZF01_RS11110
• Protein ID: WP_024706379.1
• Coordinates: 2382265..2382510 (+)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A127CJG9
• Locus tag: AZF01_RS11115
• Protein ID: WP_024706378.1
• Coordinates: 2382517..2382867 (+)
• Length: 117 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AZF01_RS11085	2378517..2379257	-	741	WP_024706384.1	hypothetical protein	-
AZF01_RS11090	2379556..2380191	-	636	WP_024706383.1	hypothetical protein	-
AZF01_RS11095	2380188..2380919	-	732	WP_024706382.1	hypothetical protein	-
AZF01_RS11100	2380912..2381358	-	447	WP_024706381.1	hypothetical protein	-
AZF01_RS11105	2381342..2382175	-	834	WP_024706380.1	YdaU family protein	-
AZF01_RS11110	2382265..2382510	+	246	WP_024706379.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
AZF01_RS11115	2382517..2382867	+	351	WP_024706378.1	helix-turn-helix transcriptional regulator	Antitoxin
AZF01_RS11120	2382939..2383220	-	282	WP_152534428.1	hypothetical protein	-
AZF01_RS11125	2383217..2383786	-	570	WP_152534427.1	hypothetical protein	-
AZF01_RS11130	2383788..2384270	-	483	WP_024706375.1	hypothetical protein	-
AZF01_RS11140	2384777..2385397	+	621	WP_024706373.1	hypothetical protein	-
AZF01_RS11145	2385881..2386423	+	543	WP_024706372.1	hypothetical protein	-
AZF01_RS24005	2386426..2386668	+	243	WP_152534426.1	hypothetical protein	-
AZF01_RS11150	2386646..2387716	+	1071	WP_024706371.1	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2350005..2403954	53949

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (59-115)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9136.80 Da
• Isoelectric Point: 10.9550

>T60619 WP_024706379.1 NZ_CP014275:2382265-2382510 [Martelella sp. AD-3]
MKTIRYTKAAMKSIQRMQPKRRNAIIARIEAFAAGETVDLKKLQGSPYFRIRVGSDRIILDDQGLIVMVIDAGPRGGIYK
E

Nucleotide

• Length: 246 bp

>T60619 NZ_CP014275:2382265-2382510 [Martelella sp. AD-3]
ATGAAGACGATCCGCTATACCAAGGCTGCGATGAAGAGCATTCAGCGCATGCAACCAAAGCGCCGCAATGCAATCATCGC
CAGGATCGAGGCTTTCGCGGCTGGTGAAACGGTCGATTTGAAGAAGCTGCAGGGCAGCCCCTATTTTCGCATCCGCGTCG
GTTCCGACCGCATCATCCTTGATGATCAGGGGTTGATCGTCATGGTCATCGACGCAGGTCCGCGCGGCGGCATTTACAAG
GAGTGA

Antitoxin

Protein

• Length: 117 a.a.
• Molecular weight: 12751.45 Da
• Isoelectric Point: 4.3141

>AT60619 WP_024706378.1 NZ_CP014275:2382517-2382867 [Martelella sp. AD-3]
MAEVQKITIEGNNYVLLREADYDDMLDSLHARAIMAGVEAGEETYPHELIVALSDESQSRLRVWRKYRGLTMKALAEKAG
ISQPYLSDIENGKADGSISAIKALAAVLDVDIDDLV

Nucleotide

• Length: 351 bp

>AT60619 NZ_CP014275:2382517-2382867 [Martelella sp. AD-3]
ATGGCCGAAGTTCAGAAGATCACTATCGAAGGCAACAATTACGTGCTGCTGCGCGAAGCCGATTACGATGACATGCTCGA
CAGCCTGCACGCCCGCGCGATCATGGCCGGCGTGGAAGCCGGAGAAGAAACCTATCCGCACGAACTGATTGTCGCGCTTT
CCGATGAGAGCCAGAGCCGCCTGCGCGTGTGGCGCAAATACCGTGGCCTGACCATGAAGGCGCTCGCAGAAAAGGCCGGC
ATTTCCCAGCCCTACCTGTCGGATATCGAAAACGGAAAGGCCGATGGCTCCATATCGGCCATAAAGGCGCTCGCCGCTGT
CCTCGATGTCGATATTGATGACCTCGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A127CJG9