Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2358993..2359583 Replicon chromosome
Accession NZ_CP014275
Organism Martelella sp. AD-3

Toxin (Protein)


Gene name hicA Uniprot ID A0A127CJ11
Locus tag AZF01_RS10950 Protein ID WP_024709685.1
Coordinates 2358993..2359175 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A127CJ09
Locus tag AZF01_RS10955 Protein ID WP_024709684.1
Coordinates 2359191..2359583 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AZF01_RS10935 2354235..2355092 - 858 WP_061449676.1 hypothetical protein -
AZF01_RS10940 2355089..2358286 - 3198 WP_051424145.1 host specificity protein J -
AZF01_RS10945 2358305..2358901 - 597 WP_024709686.1 tail assembly protein -
AZF01_RS10950 2358993..2359175 + 183 WP_024709685.1 type II toxin-antitoxin system HicA family toxin Toxin
AZF01_RS10955 2359191..2359583 + 393 WP_024709684.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AZF01_RS10960 2359799..2360095 + 297 WP_024709683.1 HigA family addiction module antidote protein -
AZF01_RS23995 2360145..2360324 + 180 WP_152534623.1 hypothetical protein -
AZF01_RS10970 2361351..2361497 + 147 WP_156484729.1 hypothetical protein -
AZF01_RS10975 2361475..2362191 - 717 WP_024709680.1 C40 family peptidase -
AZF01_RS10980 2362205..2362960 - 756 WP_024709679.1 phage minor tail protein L -
AZF01_RS10985 2362957..2363325 - 369 WP_024709678.1 hypothetical protein -
AZF01_RS10990 2363322..2363669 - 348 WP_024709677.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2350005..2403954 53949


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6883.05 Da        Isoelectric Point: 10.6579

>T60618 WP_024709685.1 NZ_CP014275:2358993-2359175 [Martelella sp. AD-3]
MDTNSRKIIKHLENDGFELVKVMGSHHKFKKGDKTVTVPHPKKDLPIGTVRNIYKQAGWL

Download         Length: 183 bp

>T60618 NZ_CP014275:2358993-2359175 [Martelella sp. AD-3]
ATGGACACCAACAGTCGAAAGATCATCAAACACTTGGAGAATGATGGCTTCGAACTGGTCAAGGTGATGGGGTCGCACCA
CAAGTTCAAAAAGGGCGACAAGACCGTCACCGTCCCTCACCCCAAGAAAGACTTGCCGATTGGCACAGTACGCAACATCT
ACAAGCAAGCCGGTTGGCTGTAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13870.58 Da        Isoelectric Point: 4.4710

>AT60618 WP_024709684.1 NZ_CP014275:2359191-2359583 [Martelella sp. AD-3]
MHYYIAVVHQEGDSAFGLHFPDVPGCFSAADDMNDLLANASEALALHLEGEELPEARSLDAVRADSDVARDLAEGAFLLA
VPFIRLSGRTTKANITMDAGLLSAVDQYAKAHGLTRSAFLADLARREIAG

Download         Length: 393 bp

>AT60618 NZ_CP014275:2359191-2359583 [Martelella sp. AD-3]
ATGCATTACTACATTGCAGTGGTTCATCAGGAAGGCGACAGCGCTTTTGGTTTGCACTTTCCGGACGTGCCCGGCTGCTT
CTCGGCAGCCGACGACATGAATGATCTTCTGGCCAATGCAAGCGAAGCGCTTGCGCTCCACCTGGAAGGCGAGGAGCTGC
CCGAAGCGCGCTCACTCGATGCCGTTCGCGCTGATAGCGACGTGGCACGTGATCTGGCCGAGGGCGCCTTTCTGCTGGCC
GTGCCCTTCATCCGATTGAGCGGCAGAACCACCAAGGCCAACATCACCATGGACGCAGGCCTCCTGAGCGCGGTCGATCA
GTATGCAAAAGCGCACGGTCTGACGCGATCCGCGTTTCTCGCCGATCTAGCACGCCGCGAAATCGCAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127CJ11

Antitoxin

Source ID Structure
AlphaFold DB A0A127CJ09

References