Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1209351..1209969 Replicon chromosome
Accession NZ_CP014269
Organism Escherichia coli B strain C3029

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag C3029_RS05905 Protein ID WP_001291435.1
Coordinates 1209351..1209569 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag C3029_RS05910 Protein ID WP_000344800.1
Coordinates 1209595..1209969 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3029_RS05870 1204640..1205212 + 573 WP_000779826.1 lipoprotein -
C3029_RS05875 1205243..1205554 - 312 WP_000409911.1 MGMT family protein -
C3029_RS05885 1205933..1206286 + 354 WP_000878140.1 DUF1428 domain-containing protein -
C3029_RS05890 1206328..1207878 - 1551 WP_001319841.1 cyclic-guanylate-specific phosphodiesterase PdeB -
C3029_RS05895 1208042..1208512 - 471 WP_000136192.1 YlaC family protein -
C3029_RS05900 1208628..1209179 - 552 WP_000102564.1 maltose O-acetyltransferase -
C3029_RS05905 1209351..1209569 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
C3029_RS05910 1209595..1209969 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
C3029_RS05915 1210515..1213664 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
C3029_RS05920 1213687..1214880 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T60490 WP_001291435.1 NZ_CP014269:c1209569-1209351 [Escherichia coli B]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T60490 NZ_CP014269:c1209569-1209351 [Escherichia coli B]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT60490 WP_000344800.1 NZ_CP014269:c1209969-1209595 [Escherichia coli B]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT60490 NZ_CP014269:c1209969-1209595 [Escherichia coli B]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References