60460

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 770125..770939 Replicon chromosome
Accession NZ_CP014268
Organism Escherichia coli B strain C2566

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag C2566_RS03785 Protein ID WP_001054376.1
Coordinates 770125..770382 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag C2566_RS03790 Protein ID WP_001309181.1
Coordinates 770394..770939 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2566_RS03760 765413..766519 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
C2566_RS03765 766584..767564 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
C2566_RS03770 768147..769387 - 1241 Protein_694 helicase YjhR -
C2566_RS24500 769503..769748 + 246 Protein_695 GNAT family N-acetyltransferase -
C2566_RS03785 770125..770382 + 258 WP_001054376.1 hypothetical protein Toxin
C2566_RS03790 770394..770939 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
C2566_RS03795 770995..771741 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
C2566_RS23940 771910..772128 + 219 Protein_699 hypothetical protein -
C2566_RS24975 772166..772282 + 117 Protein_700 VOC family protein -
C2566_RS03800 772527..773648 + 1122 WP_000010829.1 M42 family metallopeptidase -
C2566_RS03805 773645..773923 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
C2566_RS03810 773935..775248 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T60460 WP_001054376.1 NZ_CP014268:770125-770382 [Escherichia coli B]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T60460 NZ_CP014268:770125-770382 [Escherichia coli B]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT60460 WP_001309181.1 NZ_CP014268:770394-770939 [Escherichia coli B]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT60460 NZ_CP014268:770394-770939 [Escherichia coli B]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References