Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 4315285..4315856 Replicon chromosome
Accession NZ_CP014263
Organism Spirosoma montaniterrae strain DY10

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag AWR27_RS18540 Protein ID WP_077132572.1
Coordinates 4315285..4315539 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag AWR27_RS18545 Protein ID WP_198045029.1
Coordinates 4315533..4315856 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWR27_RS18530 4310409..4312481 + 2073 WP_077134070.1 large, multifunctional secreted protein -
AWR27_RS18535 4312628..4315162 - 2535 WP_077132571.1 tetratricopeptide repeat protein -
AWR27_RS18540 4315285..4315539 + 255 WP_077132572.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
AWR27_RS18545 4315533..4315856 + 324 WP_198045029.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
AWR27_RS18550 4315883..4316407 + 525 WP_077134071.1 hypothetical protein -
AWR27_RS18555 4316462..4317325 + 864 WP_077132574.1 DUF3808 domain-containing protein -
AWR27_RS18560 4317336..4318742 + 1407 WP_077132575.1 M20/M25/M40 family metallo-hydrolase -
AWR27_RS18565 4318777..4319094 + 318 WP_077132576.1 hypothetical protein -
AWR27_RS18570 4319091..4319435 + 345 WP_077132577.1 hypothetical protein -
AWR27_RS18575 4319532..4320698 + 1167 WP_077132578.1 DUF2961 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

mRNA interferase PemK-like

(4-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9746.01 Da        Isoelectric Point: 4.3115

>T60456 WP_077132572.1 NZ_CP014263:4315285-4315539 [Spirosoma montaniterrae]
MRLSVVSIGNSKGIRIPKAVLDKYRIKDSVEVEMRDDALVLKPVRTPREGWEEQFRQAITAGDLPDEELLEPFPNDFDTD
DWTW

Download         Length: 255 bp

>T60456 NZ_CP014263:4315285-4315539 [Spirosoma montaniterrae]
ATGCGCTTATCTGTCGTGTCAATCGGTAATTCCAAAGGCATTCGGATTCCGAAGGCAGTGCTCGACAAATACCGGATTAA
AGATTCGGTGGAGGTTGAGATGCGTGACGATGCCTTAGTGCTCAAACCCGTTCGCACCCCCCGCGAAGGCTGGGAAGAGC
AGTTTAGGCAGGCTATTACTGCCGGTGATTTGCCCGACGAAGAATTGCTTGAACCATTTCCGAACGACTTCGACACTGAC
GACTGGACATGGTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12258.26 Da        Isoelectric Point: 9.9161

>AT60456 WP_198045029.1 NZ_CP014263:4315533-4315856 [Spirosoma montaniterrae]
MVVKRFEVWHVNLEPTVGSEINKIRPCLIISPDTTNQFLNTVTIAALTSTRKRFPTRVNCLFNAREGQVALDQIRSVDKR
RLLNRIGELDVATAKEVCQKLQELFAY

Download         Length: 324 bp

>AT60456 NZ_CP014263:4315533-4315856 [Spirosoma montaniterrae]
ATGGTAGTGAAACGCTTTGAGGTCTGGCACGTGAACCTCGAACCAACCGTTGGCAGTGAAATCAACAAAATCCGGCCCTG
TCTGATTATTTCCCCCGACACTACGAATCAATTTCTAAATACAGTGACTATTGCCGCACTGACCAGCACCCGAAAACGTT
TTCCAACAAGGGTCAATTGCCTGTTCAATGCCCGCGAAGGGCAAGTGGCATTAGACCAGATCCGGTCGGTAGATAAACGG
CGGCTACTCAACCGAATAGGCGAACTTGATGTCGCCACTGCTAAAGAAGTATGTCAAAAATTACAGGAACTTTTCGCGTA
TTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References