Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3880763..3881410 Replicon chromosome
Accession NZ_CP014262
Organism Pseudomonas corrugata strain RM1-1-4

Toxin (Protein)


Gene name vapC Uniprot ID A0A3M3EJ95
Locus tag AXG94_RS16845 Protein ID WP_024778040.1
Coordinates 3880763..3881179 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A3M3EIH6
Locus tag AXG94_RS16850 Protein ID WP_024778041.1
Coordinates 3881180..3881410 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXG94_RS16820 3876250..3877503 - 1254 WP_055136124.1 methyltransferase -
AXG94_RS16825 3877484..3878173 - 690 WP_024778036.1 ABC transporter permease -
AXG94_RS16830 3878170..3878865 - 696 WP_024778037.1 ABC transporter permease -
AXG94_RS16835 3878944..3879699 - 756 WP_024778038.1 ABC transporter substrate-binding protein -
AXG94_RS16840 3879713..3880486 - 774 WP_024778039.1 ABC transporter ATP-binding protein -
AXG94_RS16845 3880763..3881179 - 417 WP_024778040.1 tRNA(fMet)-specific endonuclease VapC Toxin
AXG94_RS16850 3881180..3881410 - 231 WP_024778041.1 antitoxin Antitoxin
AXG94_RS16855 3881585..3882034 + 450 WP_024778042.1 hypothetical protein -
AXG94_RS16860 3882044..3882490 - 447 WP_024778043.1 hypothetical protein -
AXG94_RS16865 3882635..3883693 - 1059 WP_024778044.1 DUF1016 family protein -
AXG94_RS16870 3883933..3884340 - 408 WP_024778045.1 hypothetical protein -
AXG94_RS16875 3884406..3884735 - 330 WP_024778046.1 DHCW motif cupin fold protein -
AXG94_RS16885 3885038..3885310 - 273 WP_024778047.1 oxidative damage protection protein -
AXG94_RS16890 3885307..3886374 - 1068 WP_024778048.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3870624..3881410 10786


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15272.92 Da        Isoelectric Point: 7.2656

>T60453 WP_024778040.1 NZ_CP014262:c3881179-3880763 [Pseudomonas corrugata]
MIKFMLDTNICIFTIKNKPQMVREAFNLHHGQLCISAVTLMELIYGAEKSCAPERNLAVIEGFCARLEVLPFGYEAAAHT
GMIRAELAKAGKPIGPYDQMIAGHARSLGLIVITNNLKEFERVPGLRTEDWTVAKGPE

Download         Length: 417 bp

>T60453 NZ_CP014262:c3881179-3880763 [Pseudomonas corrugata]
ATGATCAAATTCATGCTGGATACCAACATCTGTATTTTCACCATCAAGAACAAACCCCAGATGGTCAGAGAAGCTTTCAA
TCTGCATCACGGCCAGCTTTGCATTAGTGCCGTTACGCTGATGGAGCTGATCTACGGCGCAGAAAAGTCTTGCGCCCCAG
AAAGAAATCTCGCCGTCATCGAAGGCTTCTGTGCTCGCCTTGAGGTTCTACCATTTGGTTATGAAGCTGCCGCACATACC
GGAATGATTCGAGCCGAACTGGCGAAGGCAGGCAAGCCAATCGGCCCTTACGACCAAATGATTGCCGGCCATGCCCGTTC
TCTCGGGCTGATCGTGATAACCAACAATCTGAAGGAGTTTGAAAGAGTTCCGGGACTGCGCACCGAAGATTGGACCGTTG
CGAAAGGGCCAGAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8543.58 Da        Isoelectric Point: 4.3417

>AT60453 WP_024778041.1 NZ_CP014262:c3881410-3881180 [Pseudomonas corrugata]
MEQTTLFMSNRSQAVRLPKAVAMPSDVKRVDVIAVGRARIITPAGEAWDSWFDGDTVTADFMTDRDQPADQEREPF

Download         Length: 231 bp

>AT60453 NZ_CP014262:c3881410-3881180 [Pseudomonas corrugata]
ATGGAACAAACCACCCTTTTCATGAGCAACCGCAGCCAAGCGGTCCGGCTTCCCAAAGCAGTGGCGATGCCAAGCGACGT
GAAGCGCGTAGATGTAATCGCCGTCGGCAGAGCCCGAATCATTACCCCGGCCGGAGAAGCATGGGACAGCTGGTTCGATG
GAGATACCGTGACAGCTGACTTTATGACAGACCGCGATCAGCCCGCCGATCAGGAGCGTGAACCCTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3M3EJ95

Antitoxin

Source ID Structure
AlphaFold DB A0A3M3EIH6

References