Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 995315..995868 Replicon chromosome
Accession NZ_CP014239
Organism Selenomonas sp. oral taxon 136 strain F0591

Toxin (Protein)


Gene name relE Uniprot ID A0A0X8KAD6
Locus tag AXE86_RS04775 Protein ID WP_061945210.1
Coordinates 995587..995868 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X8KAH7
Locus tag AXE86_RS04770 Protein ID WP_061945208.1
Coordinates 995315..995590 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXE86_RS04740 990600..991046 - 447 WP_061945200.1 DUF3887 domain-containing protein -
AXE86_RS04745 991080..991775 - 696 WP_009753298.1 class I SAM-dependent methyltransferase -
AXE86_RS04750 992452..992646 + 195 WP_006690537.1 4Fe-4S binding protein -
AXE86_RS04755 992648..993793 + 1146 WP_061945202.1 2-oxoacid:acceptor oxidoreductase subunit alpha -
AXE86_RS04760 993790..994638 + 849 WP_061945204.1 2-oxoglutarate ferredoxin oxidoreductase subunit beta -
AXE86_RS04765 994640..995170 + 531 WP_061945206.1 2-oxoacid:acceptor oxidoreductase family protein -
AXE86_RS04770 995315..995590 + 276 WP_061945208.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AXE86_RS04775 995587..995868 + 282 WP_061945210.1 type II toxin-antitoxin system YafQ family toxin Toxin
AXE86_RS04780 996042..997001 - 960 WP_006690543.1 L-lactate dehydrogenase -
AXE86_RS04785 997537..998385 - 849 WP_061945212.1 MTAP family purine nucleoside phosphorylase -
AXE86_RS04790 998387..999412 - 1026 WP_061945215.1 dehypoxanthine futalosine cyclase -
AXE86_RS04795 999409..1000506 - 1098 WP_061945216.1 CofH family radical SAM protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-87)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10777.51 Da        Isoelectric Point: 9.1183

>T60445 WP_061945210.1 NZ_CP014239:995587-995868 [Selenomonas sp. oral taxon 136]
MKYIIRPTSRFQRDLKRAAKRGYNTELLTAVIKKLANGEHLAQKHCDHALIGDYAGCRECHITPDWLLIYEISNDTLLLY
LTRTGTHSDLFKM

Download         Length: 282 bp

>T60445 NZ_CP014239:995587-995868 [Selenomonas sp. oral taxon 136]
ATGAAATACATTATCCGCCCAACCTCACGTTTTCAGCGGGATCTAAAACGCGCTGCCAAGCGTGGCTATAACACAGAGCT
GTTGACCGCTGTCATCAAGAAACTGGCAAATGGCGAACATCTCGCACAAAAACATTGTGACCATGCGCTCATAGGAGATT
ACGCCGGCTGTCGGGAATGTCATATTACGCCGGACTGGCTGCTCATCTATGAAATTTCCAATGACACACTGCTGCTCTAC
TTGACACGCACAGGAACACACAGCGATCTGTTCAAAATGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10443.96 Da        Isoelectric Point: 4.8282

>AT60445 WP_061945208.1 NZ_CP014239:995315-995590 [Selenomonas sp. oral taxon 136]
MGQTNVSIRMDNDLKEQFNAFCTDMGMTMTTAFNIFAKKAVREYRLPFEIGAPRPNAETQEALDEVRRMKADPSLGKRYT
DVDEMMKDLLS

Download         Length: 276 bp

>AT60445 NZ_CP014239:995315-995590 [Selenomonas sp. oral taxon 136]
ATGGGACAGACCAACGTCAGCATTCGCATGGACAATGACCTGAAGGAGCAGTTCAATGCTTTTTGTACGGATATGGGTAT
GACAATGACGACAGCATTCAACATTTTTGCCAAGAAGGCTGTACGTGAGTACCGCCTCCCTTTTGAGATCGGTGCGCCCC
GCCCCAACGCAGAGACACAGGAGGCTCTTGACGAAGTGCGCCGTATGAAGGCAGACCCTAGCCTAGGCAAACGCTACACC
GACGTTGACGAGATGATGAAAGACCTGCTCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8KAD6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8KAH7

References