Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 778486..779042 Replicon chromosome
Accession NZ_CP014239
Organism Selenomonas sp. oral taxon 136 strain F0591

Toxin (Protein)


Gene name relE Uniprot ID A0A0X8KA37
Locus tag AXE86_RS03565 Protein ID WP_061944757.1
Coordinates 778486..778770 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E0NZD7
Locus tag AXE86_RS03570 Protein ID WP_009753065.1
Coordinates 778767..779042 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXE86_RS03550 774648..776312 + 1665 WP_061944753.1 alpha-glucosidase -
AXE86_RS03555 776309..777082 + 774 WP_009753062.1 HAD-IIB family hydrolase -
AXE86_RS03560 777097..778389 + 1293 WP_061944756.1 hexokinase -
AXE86_RS03565 778486..778770 - 285 WP_061944757.1 type II toxin-antitoxin system YafQ family toxin Toxin
AXE86_RS03570 778767..779042 - 276 WP_009753065.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AXE86_RS03575 779056..779550 - 495 WP_061944760.1 HD domain-containing protein -
AXE86_RS03580 779604..779840 - 237 WP_009753067.1 AtpZ/AtpI family protein -
AXE86_RS03585 779871..781028 - 1158 WP_061944762.1 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -
AXE86_RS03590 781259..782305 - 1047 WP_009753069.1 undecaprenyl/decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase -
AXE86_RS03595 782349..782747 - 399 WP_061944765.1 hypothetical protein -
AXE86_RS03600 782744..783913 - 1170 WP_061944768.1 DUF3084 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-93)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-86)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11111.93 Da        Isoelectric Point: 9.6244

>T60444 WP_061944757.1 NZ_CP014239:c778770-778486 [Selenomonas sp. oral taxon 136]
MKNLDVVWTSQFKKDYKAAMKRRLPIELLDDVIRSLARGELLPDRNRDHALLGRWRGYRECHIQPDWLLIYRVEDTMLML
TLARTGTHSDLFGA

Download         Length: 285 bp

>T60444 NZ_CP014239:c778770-778486 [Selenomonas sp. oral taxon 136]
ATGAAGAACCTCGATGTCGTATGGACAAGTCAGTTTAAGAAAGACTATAAGGCGGCGATGAAACGCCGTCTACCCATAGA
GCTTCTTGATGATGTGATTCGCAGCTTGGCTCGCGGAGAGCTTCTTCCAGATAGGAATAGAGATCATGCTCTGCTCGGTC
GATGGCGTGGTTATCGTGAATGCCACATTCAGCCCGATTGGCTGCTCATCTATCGTGTTGAAGATACTATGCTGATGTTG
ACGCTTGCACGAACGGGTACCCATAGCGATCTGTTTGGTGCTTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10175.60 Da        Isoelectric Point: 4.5084

>AT60444 WP_009753065.1 NZ_CP014239:c779042-778767 [Selenomonas sp. oral taxon 136]
MAVVMDVNVSLDRDVKERSEALYGELGVDLTTAINVFLRQSLRVGGFPFEVRMDVPNNETSAALMEAEHLLHDPSVKRYS
DVEEALRVLKA

Download         Length: 276 bp

>AT60444 NZ_CP014239:c779042-778767 [Selenomonas sp. oral taxon 136]
ATGGCTGTTGTTATGGATGTCAATGTTTCTCTAGATCGTGATGTGAAAGAACGGAGCGAGGCGCTGTATGGTGAACTTGG
CGTGGATCTGACGACAGCAATCAATGTATTTCTTCGTCAGTCACTTCGTGTCGGAGGATTTCCGTTCGAGGTACGTATGG
ATGTTCCGAACAATGAAACTTCCGCAGCACTGATGGAAGCAGAACATCTTTTGCACGATCCATCAGTCAAGCGATACTCC
GATGTTGAGGAAGCGTTGAGGGTACTCAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8KA37

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8K9Z9

References