Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 5485..7237 Replicon plasmid unnamed4
Accession NZ_CP014235
Organism Moraxella osloensis strain CCUG 350

Toxin (Protein)


Gene name pmenT Uniprot ID A0A378QVB8
Locus tag AXE82_RS10840 Protein ID WP_062334985.1
Coordinates 5485..6135 (+) Length 217 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID A0A0X8K8B7
Locus tag AXE82_RS10845 Protein ID WP_036590386.1
Coordinates 6137..7237 (+) Length 367 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXE82_RS10815 2551..3183 + 633 WP_036590402.1 AAA family ATPase -
AXE82_RS10820 3194..3409 + 216 WP_036590400.1 hypothetical protein -
AXE82_RS10825 3833..4318 + 486 WP_147285577.1 hypothetical protein -
AXE82_RS12220 4489..4632 + 144 WP_156627545.1 hypothetical protein -
AXE82_RS10830 4878..5168 + 291 WP_062334983.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
AXE82_RS10835 5207..5434 + 228 WP_062335085.1 type II toxin-antitoxin system YafQ family toxin -
AXE82_RS10840 5485..6135 + 651 WP_062334985.1 DUF4433 domain-containing protein Toxin
AXE82_RS10845 6137..7237 + 1101 WP_036590386.1 macro domain-containing protein Antitoxin
AXE82_RS10850 7538..8146 + 609 WP_062334986.1 recombinase family protein -
AXE82_RS10855 8310..8633 + 324 WP_062334988.1 type II toxin-antitoxin system RelE/ParE family toxin -
AXE82_RS10860 8620..8907 + 288 WP_062334989.1 putative addiction module antidote protein -
AXE82_RS10865 9132..9674 + 543 WP_062334990.1 helix-turn-helix domain-containing protein -
AXE82_RS10870 9605..10501 + 897 Protein_14 IS3 family transposase -
AXE82_RS11925 10597..11589 - 993 Protein_15 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81455 81455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-216)

Antitoxin

Macro domain

(18-142)


Sequences

Toxin        


Download         Length: 217 a.a.        Molecular weight: 25125.49 Da        Isoelectric Point: 6.6876

>T60441 WP_062334985.1 NZ_CP014235:5485-6135 [Moraxella osloensis]
MTYDYSNTLNPNKGLIWRIVHIANLPWIFANGLHSGNSPIQSPNWQHIGNPELIQKRAKHPVPVGPQGYLNDYVPFYFTP
FSPMLLNIKSGRGVMQRPMQDIVILVSSIDAVESHHLDYVFTNSHAYYQWTNFFTDKQDLDQIDWALLQRRDFSRDPNDL
AKFERYQAEFLIYHQCPISAIIGICCYDDNVKQSIQQLINTSGITLDVYSRPNWYL

Download         Length: 651 bp

>T60441 NZ_CP014235:5485-6135 [Moraxella osloensis]
ATGACTTATGATTATAGTAATACATTAAACCCAAACAAAGGACTGATATGGCGGATTGTCCATATTGCGAATTTACCATG
GATTTTTGCCAATGGCTTGCACAGTGGCAATAGCCCTATTCAATCGCCTAACTGGCAGCATATCGGTAACCCTGAGCTTA
TCCAAAAACGTGCCAAACATCCTGTTCCAGTAGGACCACAAGGCTATCTCAATGATTATGTGCCGTTTTACTTTACCCCA
TTTTCGCCCATGTTACTTAATATAAAATCAGGTCGCGGTGTGATGCAAAGACCCATGCAAGATATCGTGATTTTGGTATC
GTCTATTGATGCGGTAGAAAGCCATCATTTGGACTATGTTTTTACCAATAGCCATGCTTATTACCAATGGACTAATTTTT
TTACTGACAAACAAGACCTAGACCAAATCGATTGGGCATTATTGCAGCGCCGTGATTTTAGCCGTGATCCCAATGACTTG
GCAAAATTTGAGCGTTATCAAGCCGAATTTTTGATTTATCATCAATGCCCCATATCAGCAATTATCGGTATCTGTTGTTA
TGATGACAACGTCAAACAAAGCATTCAACAATTAATCAATACGTCTGGCATTACATTGGATGTATATAGCCGACCCAACT
GGTATCTTTGA

Antitoxin


Download         Length: 367 a.a.        Molecular weight: 41845.12 Da        Isoelectric Point: 7.1732

>AT60441 WP_036590386.1 NZ_CP014235:6137-7237 [Moraxella osloensis]
MITYTQGNLLESNAQALVNTVNTVGVMGKGIALMFKQQFPENFKRYAKACKSGDVKVGEMFVVEVSTSSTQHSQLQAQPH
HKQRWIVNFPTKQHWRAKSKIEWIQAGLQNLRQWLIDNHVESIAIPPLGAGNGGLPWQQVKPLIEQALGDLLNIDIQIFE
PSDSYHSVATAPTTDSLTHARALLYQVIDRYWVLGMECSLLEVHKLMWFLQRAIERHRLVNPLQLSFMPHYYGTYAPNLR
HLLNHLDGSYLLAEKRLPDCKPLDVIWANQTKQAEVEQYLQTSMSDFLPVLIEVDKVIAGFESPFGLELLSTVDWLIYQE
QYPATVEGVRQGMANWSAGEVWAKRKLNLFNVQHIDFALQHLKTIY

Download         Length: 1101 bp

>AT60441 NZ_CP014235:6137-7237 [Moraxella osloensis]
ATGATTACATACACCCAAGGTAATTTACTTGAATCAAATGCTCAAGCTTTGGTTAATACCGTCAATACCGTCGGTGTGAT
GGGCAAAGGTATTGCGTTAATGTTTAAACAACAATTTCCCGAAAATTTCAAACGCTATGCCAAAGCGTGCAAATCAGGGG
ATGTGAAAGTCGGTGAAATGTTTGTGGTTGAAGTTAGTACCTCATCGACTCAACACTCACAGTTACAAGCACAGCCTCAC
CATAAGCAAAGATGGATAGTGAATTTCCCAACCAAACAGCATTGGAGAGCTAAATCAAAAATCGAATGGATACAAGCAGG
ACTGCAGAATTTGCGACAATGGTTAATTGATAATCATGTCGAATCGATAGCTATTCCCCCATTAGGTGCGGGTAATGGCG
GACTGCCCTGGCAACAGGTAAAACCCCTTATCGAACAAGCCTTGGGTGATTTACTAAATATTGATATTCAAATTTTTGAA
CCATCAGATAGTTATCATAGCGTTGCGACTGCACCCACAACTGACAGTCTCACCCATGCCAGAGCCTTGTTGTATCAAGT
GATTGACCGTTATTGGGTGCTTGGTATGGAGTGTAGTTTGCTTGAAGTGCATAAGCTGATGTGGTTTTTGCAACGAGCGA
TTGAGCGTCATCGTTTAGTCAATCCGCTACAGTTATCATTTATGCCACATTATTATGGTACTTATGCCCCAAATCTGCGT
CATTTGCTCAATCACCTAGACGGTAGCTATCTATTGGCTGAAAAACGTCTGCCAGATTGCAAACCTTTGGATGTCATTTG
GGCTAACCAAACCAAACAAGCTGAAGTTGAGCAGTATTTGCAAACGTCAATGTCAGATTTTTTACCTGTTTTGATAGAAG
TTGATAAAGTGATAGCAGGATTTGAGTCGCCGTTTGGTTTGGAGCTGCTATCTACCGTGGATTGGCTGATCTATCAAGAA
CAATATCCCGCTACAGTGGAAGGTGTTAGGCAAGGTATGGCAAATTGGTCAGCAGGGGAAGTTTGGGCAAAACGCAAATT
GAATTTATTTAATGTTCAGCATATTGATTTTGCCCTGCAACATTTGAAAACTATTTATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378QVB8

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8K8B7

References