Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/couple_hipB(antitoxin)
Location 1769210..1769733 Replicon chromosome
Accession NZ_CP014234
Organism Moraxella osloensis strain CCUG 350

Toxin (Protein)


Gene name hipA Uniprot ID A0A109WBX0
Locus tag AXE82_RS07815 Protein ID WP_062333327.1
Coordinates 1769512..1769733 (-) Length 74 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A378QGA6
Locus tag AXE82_RS07810 Protein ID WP_062333324.1
Coordinates 1769210..1769515 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXE82_RS07785 1765107..1766807 + 1701 WP_062333310.1 DUF262 domain-containing HNH endonuclease family protein -
AXE82_RS07790 1766956..1767321 + 366 WP_082741438.1 metallophosphoesterase -
AXE82_RS07795 1767302..1767562 + 261 WP_062333316.1 hypothetical protein -
AXE82_RS07800 1767579..1768661 + 1083 WP_062333319.1 WYL domain-containing protein -
AXE82_RS07805 1768868..1769113 + 246 WP_062333322.1 hypothetical protein -
AXE82_RS07810 1769210..1769515 - 306 WP_062333324.1 helix-turn-helix domain-containing protein Antitoxin
AXE82_RS07815 1769512..1769733 - 222 WP_062333327.1 hypothetical protein Toxin
AXE82_RS07820 1769955..1773518 - 3564 WP_082741489.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-94)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8452.91 Da        Isoelectric Point: 4.9859

>T60440 WP_062333327.1 NZ_CP014234:c1769733-1769512 [Moraxella osloensis]
MLFQGRYNFIAICESLSDLIEPSILLEELKQTAEKLVDLPNRLQQRGVSEKILLHPAIAFDYLPKRLQDWGLL

Download         Length: 222 bp

>T60440 NZ_CP014234:c1769733-1769512 [Moraxella osloensis]
ATGCTTTTTCAAGGTCGTTATAACTTTATCGCCATCTGTGAGAGCTTGTCAGATTTGATAGAGCCTTCAATTTTACTTGA
AGAACTTAAGCAAACTGCCGAGAAATTGGTCGATTTACCGAATCGATTGCAACAACGAGGCGTCAGTGAAAAAATCTTAT
TGCATCCAGCGATTGCGTTTGATTATTTGCCAAAACGCTTACAAGACTGGGGATTGCTATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11455.08 Da        Isoelectric Point: 10.0912

>AT60440 WP_062333324.1 NZ_CP014234:c1769515-1769210 [Moraxella osloensis]
MNNLLNRQRASDAAPDLQGLSRTQARDQVIEQFMQGELTQGELLKKLRIDILGVKQDAFATLVKFSRKTISDVENDNGNY
SVNTINQIFRPFGLVLKLGYR

Download         Length: 306 bp

>AT60440 NZ_CP014234:c1769515-1769210 [Moraxella osloensis]
ATGAATAACTTACTAAATCGTCAGCGGGCGTCTGATGCCGCACCCGATTTACAAGGATTAAGTCGCACGCAGGCCCGAGA
CCAAGTGATTGAGCAATTTATGCAAGGTGAATTGACCCAAGGTGAACTGCTAAAGAAACTCCGTATTGATATACTAGGGG
TTAAACAAGATGCGTTTGCAACATTGGTCAAGTTCTCTCGTAAAACGATTTCTGACGTGGAAAATGACAATGGCAATTAT
AGTGTCAATACGATTAATCAGATTTTCCGGCCATTTGGATTAGTACTTAAATTGGGGTATCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A109WBX0

Antitoxin

Source ID Structure
AlphaFold DB A0A378QGA6

References