Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1547588..1548243 Replicon chromosome
Accession NZ_CP014234
Organism Moraxella osloensis strain CCUG 350

Toxin (Protein)


Gene name vapC Uniprot ID A0A109WBT2
Locus tag AXE82_RS06770 Protein ID WP_062332881.1
Coordinates 1547842..1548243 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A378Q6B5
Locus tag AXE82_RS06765 Protein ID WP_062332879.1
Coordinates 1547588..1547824 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXE82_RS06750 1542594..1544255 + 1662 WP_062332873.1 electron transfer flavoprotein-ubiquinone oxidoreductase -
AXE82_RS06755 1544714..1544893 - 180 WP_036592470.1 hypothetical protein -
AXE82_RS06760 1545116..1547296 - 2181 WP_115304570.1 ATP-dependent DNA helicase RecG -
AXE82_RS06765 1547588..1547824 + 237 WP_062332879.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AXE82_RS06770 1547842..1548243 + 402 WP_062332881.1 tRNA(fMet)-specific endonuclease VapC Toxin
AXE82_RS06775 1548247..1549131 + 885 WP_062332884.1 patatin-like phospholipase family protein -
AXE82_RS06780 1549198..1549731 - 534 WP_062332887.1 hypothetical protein -
AXE82_RS06785 1550249..1551607 + 1359 WP_062334846.1 amino-acid N-acetyltransferase -
AXE82_RS06790 1551704..1552498 - 795 WP_062332890.1 FKBP-type peptidyl-prolyl cis-trans isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(9-55)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14941.02 Da        Isoelectric Point: 6.8695

>T60439 WP_062332881.1 NZ_CP014234:1547842-1548243 [Moraxella osloensis]
MLTFMLDTNIAIHVIKQRPIAALNKFNQYAARICVSSITVAELYFGAENSQNLAKNLAQVDDFLSRLVILDYDSQAGSHY
GNIYADLTKKGNVISENDMHIAGHARSRGLILVTNNLREFERVEGLRLDNWVS

Download         Length: 402 bp

>T60439 NZ_CP014234:1547842-1548243 [Moraxella osloensis]
ATGCTGACCTTTATGCTAGACACCAATATCGCCATCCACGTCATCAAACAACGTCCGATTGCGGCTTTAAATAAATTCAA
CCAATATGCCGCTAGAATTTGTGTCAGTAGTATCACAGTAGCGGAATTGTATTTTGGCGCGGAAAACAGCCAAAATCTGG
CTAAAAACTTGGCACAAGTGGATGATTTTTTATCACGTTTGGTTATCCTTGATTATGATAGCCAAGCGGGAAGTCATTAC
GGCAATATTTATGCTGACTTGACTAAAAAAGGTAACGTCATTAGCGAAAATGACATGCATATCGCAGGTCATGCCCGTAG
CCGCGGCTTAATTTTGGTGACCAATAATCTAAGAGAGTTTGAGCGTGTCGAAGGATTACGGTTAGATAACTGGGTGTCAT
AA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8982.15 Da        Isoelectric Point: 7.2032

>AT60439 WP_062332879.1 NZ_CP014234:1547588-1547824 [Moraxella osloensis]
MTQASVFFNNRTQAVRLPADMRFADDIKHVHIRKVGNERILTPITNVWDSFFIAKDPVSDDFMAQRGNAPISQRESFD

Download         Length: 237 bp

>AT60439 NZ_CP014234:1547588-1547824 [Moraxella osloensis]
ATGACCCAAGCTAGCGTATTTTTTAACAACCGCACCCAAGCTGTGCGCTTACCTGCGGATATGCGATTTGCTGATGACAT
CAAACATGTTCATATACGCAAAGTCGGTAACGAACGTATTTTAACCCCTATCACTAACGTATGGGATAGCTTTTTTATTG
CTAAAGACCCCGTCAGCGATGACTTTATGGCACAGCGTGGCAACGCCCCTATCAGCCAACGCGAAAGCTTTGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A109WBT2

Antitoxin

Source ID Structure
AlphaFold DB A0A378Q6B5

References