Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 747090..747661 Replicon chromosome
Accession NZ_CP014232
Organism Actinomyces oris strain T14V

Toxin (Protein)


Gene name vapC Uniprot ID A0A0X8K100
Locus tag AXE84_RS03195 Protein ID WP_060956813.1
Coordinates 747284..747661 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID F2UXK9
Locus tag AXE84_RS03190 Protein ID WP_003787711.1
Coordinates 747090..747287 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXE84_RS03180 743049..744356 - 1308 WP_060956811.1 phosphoribosylamine--glycine ligase -
AXE84_RS03185 744522..746834 + 2313 WP_060956812.1 TerD family protein -
AXE84_RS03190 747090..747287 + 198 WP_003787711.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
AXE84_RS03195 747284..747661 + 378 WP_060956813.1 type II toxin-antitoxin system VapC family toxin Toxin
AXE84_RS03200 747743..748348 + 606 WP_060956814.1 hypothetical protein -
AXE84_RS03205 748336..749586 - 1251 WP_060956815.1 hypothetical protein -
AXE84_RS03210 750564..752411 - 1848 WP_060956816.1 phosphoenolpyruvate carboxykinase (GTP) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-42)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13746.71 Da        Isoelectric Point: 6.2638

>T60435 WP_060956813.1 NZ_CP014232:747284-747661 [Actinomyces oris]
VILVDTSVWIDHFHHSDPVLVSLLHEDEIGSHPLVAEELAMGSLRARDDVLRHLAHLHRFPVLSHDELLVLVAAHALWGQ
GLSPVDAHLLGSVTLVPGARLWTRDKRLLRAAEERGVSFTEGTAG

Download         Length: 378 bp

>T60435 NZ_CP014232:747284-747661 [Actinomyces oris]
GTGATCCTTGTCGACACCTCGGTATGGATCGATCACTTCCACCACTCGGACCCAGTACTCGTCAGCCTGCTGCACGAGGA
CGAGATCGGATCCCATCCACTCGTGGCGGAGGAGCTGGCGATGGGGTCACTCAGGGCCAGGGACGACGTCCTCAGGCACT
TAGCGCACCTCCACCGGTTCCCGGTCCTCTCACATGACGAACTACTGGTCCTAGTCGCAGCGCATGCACTGTGGGGCCAA
GGACTCAGCCCAGTTGATGCGCACCTGCTCGGCTCCGTCACGCTGGTCCCTGGCGCCCGCCTGTGGACACGCGACAAGCG
ATTGCTCCGCGCTGCCGAAGAGCGCGGAGTCTCCTTCACCGAAGGAACCGCCGGCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6949.80 Da        Isoelectric Point: 11.5457

>AT60435 WP_003787711.1 NZ_CP014232:747090-747287 [Actinomyces oris]
VRTTVTLSDDLIANAQELTGITERTELLRAGLETLVRVESARRLAALGGSDRTASAAPRRRSASQ

Download         Length: 198 bp

>AT60435 NZ_CP014232:747090-747287 [Actinomyces oris]
GTGCGAACCACCGTGACACTCAGTGATGACCTCATTGCCAACGCGCAAGAGCTCACAGGCATCACTGAGCGCACCGAGCT
GCTGCGGGCCGGCCTGGAGACCCTGGTCAGAGTGGAGAGCGCACGTCGCCTTGCGGCTCTCGGCGGCTCTGATCGGACGG
CAAGCGCCGCTCCACGACGTCGGAGCGCCAGCCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8K100

Antitoxin

Source ID Structure
AlphaFold DB A0A1F1VW34

References