60434

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 658137..658642 Replicon chromosome
Accession NZ_CP014232
Organism Actinomyces oris strain T14V

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0X8K0W4
Locus tag AXE84_RS02825 Protein ID WP_060956758.1
Coordinates 658137..658391 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X8K1F7
Locus tag AXE84_RS02830 Protein ID WP_060956759.1
Coordinates 658391..658642 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXE84_RS02815 653483..654703 + 1221 WP_060956756.1 homoserine O-acetyltransferase -
AXE84_RS02820 654967..657672 + 2706 WP_060956757.1 exo-alpha-sialidase -
AXE84_RS12415 657968..658090 - 123 WP_081093036.1 hypothetical protein -
AXE84_RS02825 658137..658391 - 255 WP_060956758.1 Txe/YoeB family addiction module toxin Toxin
AXE84_RS02830 658391..658642 - 252 WP_060956759.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AXE84_RS02835 658816..659139 + 324 WP_060958119.1 HigA family addiction module antidote protein -
AXE84_RS02840 659296..660899 - 1604 Protein_565 cation:proton antiporter -
AXE84_RS02845 661089..662333 - 1245 WP_060956760.1 type II toxin-antitoxin system HipA family toxin -
AXE84_RS02850 662330..662617 - 288 WP_060956761.1 helix-turn-helix domain-containing protein -
AXE84_RS12425 662876..663173 - 298 Protein_568 ribbon-helix-helix protein, CopG family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9971.43 Da        Isoelectric Point: 9.6770

>T60434 WP_060956758.1 NZ_CP014232:c658391-658137 [Actinomyces oris]
MRLVWDPYAWEDYKHWQKADRRILKRVNTLIDAALRDPFGGIGKPEQLKYGASGAWSRRITDEHRLVYLVAGDDLVILQV
RYHY

Download         Length: 255 bp

>T60434 NZ_CP014232:c658391-658137 [Actinomyces oris]
ATGCGTCTCGTATGGGATCCGTATGCTTGGGAGGACTATAAGCACTGGCAGAAGGCGGACCGCAGGATCCTCAAACGGGT
CAACACGCTCATTGATGCGGCGCTTCGCGATCCCTTCGGAGGTATCGGGAAACCCGAGCAGCTCAAGTACGGCGCCTCGG
GCGCGTGGTCGCGAAGGATTACTGACGAGCATCGCCTCGTGTACCTCGTTGCTGGCGATGACCTGGTGATTCTCCAAGTT
CGCTACCACTACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9455.49 Da        Isoelectric Point: 4.6533

>AT60434 WP_060956759.1 NZ_CP014232:c658642-658391 [Actinomyces oris]
MSISASEARKTLYPLIERVNADHDAVEIVSRKGSAVLMPADEYAAWQETAYLFRSPENARRLLDAYDRARAGQTEMHDLD
RED

Download         Length: 252 bp

>AT60434 NZ_CP014232:c658642-658391 [Actinomyces oris]
ATGTCTATCAGTGCAAGCGAGGCGCGTAAGACGTTGTACCCGCTCATCGAGCGAGTCAACGCCGATCATGACGCCGTTGA
GATTGTCTCGCGTAAGGGCAGTGCTGTTCTTATGCCCGCCGACGAGTACGCTGCTTGGCAGGAGACCGCCTACCTGTTCC
GATCACCTGAGAACGCGCGACGCCTTCTTGATGCGTATGACCGGGCTCGTGCGGGCCAGACGGAGATGCATGACCTCGAC
CGGGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8K0W4

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8K1F7

References