Detailed information of TA system TA060433

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 657968..658391
• Replicon: chromosome
• Accession: NZ_CP014232
• Organism: Actinomyces oris strain T14V

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A0X8K0W4
• Locus tag: AXE84_RS02825
• Protein ID: WP_060956758.1
• Coordinates: 658137..658391 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AXE84_RS12415
• Protein ID: WP_081093036.1
• Coordinates: 657968..658090 (-)
• Length: 41 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXE84_RS02815	653483..654703	+	1221	WP_060956756.1	homoserine O-acetyltransferase	-
AXE84_RS02820	654967..657672	+	2706	WP_060956757.1	exo-alpha-sialidase	-
AXE84_RS12415	657968..658090	-	123	WP_081093036.1	hypothetical protein	Antitoxin
AXE84_RS02825	658137..658391	-	255	WP_060956758.1	Txe/YoeB family addiction module toxin	Toxin
AXE84_RS02830	658391..658642	-	252	WP_060956759.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
AXE84_RS02835	658816..659139	+	324	WP_060958119.1	HigA family addiction module antidote protein	-
AXE84_RS02840	659296..660899	-	1604	Protein_565	cation:proton antiporter	-
AXE84_RS02845	661089..662333	-	1245	WP_060956760.1	type II toxin-antitoxin system HipA family toxin	-
AXE84_RS02850	662330..662617	-	288	WP_060956761.1	helix-turn-helix domain-containing protein	-
AXE84_RS12425	662876..663173	-	298	Protein_568	ribbon-helix-helix protein, CopG family	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9971.43 Da
• Isoelectric Point: 9.6770

>T60433 WP_060956758.1 NZ_CP014232:c658391-658137 [Actinomyces oris]
MRLVWDPYAWEDYKHWQKADRRILKRVNTLIDAALRDPFGGIGKPEQLKYGASGAWSRRITDEHRLVYLVAGDDLVILQV
RYHY

Nucleotide

• Length: 255 bp

>T60433 NZ_CP014232:c658391-658137 [Actinomyces oris]
ATGCGTCTCGTATGGGATCCGTATGCTTGGGAGGACTATAAGCACTGGCAGAAGGCGGACCGCAGGATCCTCAAACGGGT
CAACACGCTCATTGATGCGGCGCTTCGCGATCCCTTCGGAGGTATCGGGAAACCCGAGCAGCTCAAGTACGGCGCCTCGG
GCGCGTGGTCGCGAAGGATTACTGACGAGCATCGCCTCGTGTACCTCGTTGCTGGCGATGACCTGGTGATTCTCCAAGTT
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 41 a.a.
• Molecular weight: 4610.10 Da
• Isoelectric Point: 5.6594

>AT60433 WP_081093036.1 NZ_CP014232:c658090-657968 [Actinomyces oris]
MPADEYASWQETAHLFRSLKNARRLLDAYEQALTDSGPRT

Nucleotide

• Length: 123 bp

>AT60433 NZ_CP014232:c658090-657968 [Actinomyces oris]
ATGCCGGCCGACGAGTACGCGAGTTGGCAGGAGACCGCCCACCTCTTCCGGTCACTCAAGAACGCCCGGCGTCTGCTCGA
TGCATACGAACAGGCTCTCACGGACTCTGGCCCTCGAACCTGA

Structures

Toxin

• AlphaFold DB: A0A0X8K0W4