Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-Axe/YoeB-RelB
Location 1258183..1258684 Replicon chromosome
Accession NZ_CP014231
Organism Leptotrichia sp. oral taxon 847 strain F0260

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0X8JUR2
Locus tag AXF11_RS05830 Protein ID WP_068155786.1
Coordinates 1258430..1258684 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID A0A0X8JUI7
Locus tag AXF11_RS05825 Protein ID WP_068155783.1
Coordinates 1258183..1258437 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXF11_RS05805 1254168..1255289 + 1122 WP_068155776.1 ATP-binding protein -
AXF11_RS05810 1255282..1256052 + 771 WP_068155778.1 hypothetical protein -
AXF11_RS05815 1256061..1257176 + 1116 WP_068155780.1 glycosyltransferase family 4 protein -
AXF11_RS05820 1257192..1258049 + 858 WP_068155781.1 dTDP-4-dehydrorhamnose reductase -
AXF11_RS05825 1258183..1258437 + 255 WP_068155783.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AXF11_RS05830 1258430..1258684 + 255 WP_068155786.1 Txe/YoeB family addiction module toxin Toxin
AXF11_RS05835 1258972..1260099 + 1128 WP_082729433.1 glycoside hydrolase family 16 protein -
AXF11_RS05840 1260115..1261083 + 969 WP_068155787.1 ribose-phosphate pyrophosphokinase -
AXF11_RS05845 1261093..1261704 + 612 WP_068155791.1 class I SAM-dependent methyltransferase -
AXF11_RS05850 1261719..1262429 + 711 WP_156440391.1 N-acetylmuramoyl-L-alanine amidase -
AXF11_RS05855 1262887..1263267 + 381 WP_068155792.1 30S ribosomal protein S12 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9994.34 Da        Isoelectric Point: 9.3929

>T60430 WP_068155786.1 NZ_CP014231:1258430-1258684 [Leptotrichia sp. oral taxon 847]
MNKLWTDEGWSDYLYWQSQDKKTLKRINELIKDIERNGALNGIGKPEALKYRKGFSRRIDEANRLVYTIDENGTLWIISC
RGHY

Download         Length: 255 bp

>T60430 NZ_CP014231:1258430-1258684 [Leptotrichia sp. oral taxon 847]
ATGAATAAATTATGGACTGATGAAGGATGGAGCGATTATTTATATTGGCAGTCTCAAGATAAAAAGACTTTGAAACGAAT
CAATGAACTTATAAAAGATATTGAAAGAAATGGGGCATTAAATGGTATAGGTAAACCCGAAGCTTTAAAATATAGAAAAG
GATTTAGTCGAAGAATTGATGAAGCGAATAGGCTTGTATACACTATTGATGAAAATGGGACTTTGTGGATAATTTCTTGT
AGAGGACATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9707.07 Da        Isoelectric Point: 6.9794

>AT60430 WP_068155783.1 NZ_CP014231:1258183-1258437 [Leptotrichia sp. oral taxon 847]
MLAVNFSTMRNNLKSYCDKAVKENEDVIVTRKNEENVVLINLKKYNQFLKAVKNSEYLAKLDRGFEQVKSGKGQVHDLIE
VDDE

Download         Length: 255 bp

>AT60430 NZ_CP014231:1258183-1258437 [Leptotrichia sp. oral taxon 847]
ATGTTGGCTGTAAATTTTTCAACCATGAGAAATAATTTAAAAAGTTACTGTGATAAGGCAGTAAAAGAAAATGAAGATGT
AATAGTAACAAGAAAAAATGAAGAAAATGTAGTTTTAATAAATCTCAAAAAATATAATCAATTTTTGAAAGCAGTTAAAA
ATTCTGAATATCTTGCGAAATTGGATAGAGGATTTGAGCAGGTAAAAAGTGGAAAAGGACAAGTGCATGATTTGATAGAG
GTTGACGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8JUR2

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8JUI7

References