Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 986913..987385 Replicon chromosome
Accession NZ_CP014231
Organism Leptotrichia sp. oral taxon 847 strain F0260

Toxin (Protein)


Gene name relE Uniprot ID A0A109W7B4
Locus tag AXF11_RS04515 Protein ID WP_068155336.1
Coordinates 987113..987385 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C9N208
Locus tag AXF11_RS04510 Protein ID WP_006806162.1
Coordinates 986913..987128 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXF11_RS04490 982234..983742 + 1509 WP_068155330.1 coproporphyrinogen III oxidase -
AXF11_RS04495 983885..985096 + 1212 WP_068153993.1 IS256 family transposase -
AXF11_RS04500 985453..985863 - 411 WP_068155332.1 hypothetical protein -
AXF11_RS04505 985869..986753 - 885 WP_197416849.1 hypothetical protein -
AXF11_RS04510 986913..987128 + 216 WP_006806162.1 hypothetical protein Antitoxin
AXF11_RS04515 987113..987385 + 273 WP_068155336.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AXF11_RS04520 987518..988444 - 927 WP_068155338.1 replication initiation protein -
AXF11_RS04525 989006..989707 - 702 WP_068155340.1 hypothetical protein -
AXF11_RS04530 990010..990903 - 894 WP_068155341.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-88)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10671.58 Da        Isoelectric Point: 10.9265

>T60429 WP_068155336.1 NZ_CP014231:987113-987385 [Leptotrichia sp. oral taxon 847]
MGRTVKYKIIPTPHFVKDFSKLDEFVKKRIKIYLENIAKDPRSKGKILKANRKGQWRYRIGNYRVIVNIQDENLVVLALE
VGHRKNIYNS

Download         Length: 273 bp

>T60429 NZ_CP014231:987113-987385 [Leptotrichia sp. oral taxon 847]
ATGGGAAGAACTGTAAAATATAAAATAATCCCAACTCCACATTTCGTAAAAGATTTTAGCAAACTAGATGAATTTGTAAA
AAAGAGAATAAAAATTTATTTAGAAAATATTGCAAAAGATCCACGCAGTAAAGGAAAAATATTGAAAGCAAATAGAAAAG
GACAATGGAGATACAGAATAGGAAATTACAGAGTTATTGTAAATATTCAAGATGAAAATTTAGTAGTGTTAGCATTAGAA
GTAGGGCATAGAAAAAATATTTATAATAGTTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8155.29 Da        Isoelectric Point: 4.2346

>AT60429 WP_006806162.1 NZ_CP014231:986913-987128 [Leptotrichia sp. oral taxon 847]
MASISLKVSDMEKKFLQSMAQFEGVTLSELIKSKVFDSLEDEYDAKIADLRLSEYESYLKNGGEVLKWEEL

Download         Length: 216 bp

>AT60429 NZ_CP014231:986913-987128 [Leptotrichia sp. oral taxon 847]
ATGGCTTCTATAAGTTTAAAAGTGTCTGATATGGAAAAAAAATTTTTGCAAAGTATGGCACAATTTGAAGGTGTTACATT
GTCAGAGTTAATAAAATCAAAAGTGTTTGACTCATTGGAAGATGAATATGATGCCAAAATAGCAGATTTAAGATTATCAG
AATATGAAAGCTATTTGAAAAATGGAGGAGAAGTTTTAAAATGGGAAGAACTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A109W7B4

Antitoxin

Source ID Structure
AlphaFold DB A0A510KIG5

References