Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 177904..178480 Replicon chromosome
Accession NZ_CP014231
Organism Leptotrichia sp. oral taxon 847 strain F0260

Toxin (Protein)


Gene name relE Uniprot ID A0A120KP40
Locus tag AXF11_RS00835 Protein ID WP_068154068.1
Coordinates 177904..178200 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A109W6W6
Locus tag AXF11_RS00840 Protein ID WP_068154069.1
Coordinates 178190..178480 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXF11_RS00820 173533..175551 + 2019 WP_082729355.1 NAD-dependent DNA ligase LigA -
AXF11_RS00825 175722..176219 - 498 WP_068154066.1 hypothetical protein -
AXF11_RS00830 176819..177826 - 1008 WP_068154067.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
AXF11_RS00835 177904..178200 - 297 WP_068154068.1 type II toxin-antitoxin system YafQ family toxin Toxin
AXF11_RS00840 178190..178480 - 291 WP_068154069.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AXF11_RS00845 178799..180310 - 1512 WP_068154070.1 hypothetical protein -
AXF11_RS00850 180312..180944 - 633 WP_068154071.1 hypothetical protein -
AXF11_RS00855 180997..183459 - 2463 WP_068154072.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(11-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-87)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11459.57 Da        Isoelectric Point: 9.9713

>T60428 WP_068154068.1 NZ_CP014231:c178200-177904 [Leptotrichia sp. oral taxon 847]
MRDKKEEYKYSIILTGKFKKHLKNLKKQKKDLKLLESIISILAKGEKLPPKNKDHKLVNNYDGARECHITPDWLLIYEIV
EDKLILILLASGSHSELF

Download         Length: 297 bp

>T60428 NZ_CP014231:c178200-177904 [Leptotrichia sp. oral taxon 847]
ATGAGGGATAAAAAAGAAGAGTATAAATATTCTATTATTCTTACTGGGAAATTTAAAAAACATTTAAAAAATCTAAAAAA
ACAGAAAAAAGATTTAAAATTATTGGAAAGTATCATCTCAATATTGGCAAAAGGAGAAAAACTTCCTCCTAAAAACAAGG
ATCATAAATTAGTCAATAATTATGATGGAGCAAGAGAATGTCATATAACTCCAGATTGGTTATTAATCTACGAGATAGTT
GAAGATAAATTAATATTGATTTTATTAGCATCAGGTAGTCATAGTGAACTATTCTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10882.26 Da        Isoelectric Point: 4.4519

>AT60428 WP_068154069.1 NZ_CP014231:c178480-178190 [Leptotrichia sp. oral taxon 847]
MATVNTSIKIDEETKKEAQELFKDLGLSLSTAINIFLKQAIREKGIPFYINSLPENSELAQAFEEAKQIKKNPSNYKSYS
SPEEMFKDVLGEDYEG

Download         Length: 291 bp

>AT60428 NZ_CP014231:c178480-178190 [Leptotrichia sp. oral taxon 847]
ATGGCAACAGTTAATACAAGTATAAAAATAGATGAAGAAACTAAAAAAGAAGCACAGGAATTATTTAAAGATTTAGGATT
AAGTCTTAGTACAGCAATTAATATATTTTTAAAACAGGCTATAAGAGAAAAAGGCATACCATTTTATATAAATTCTTTAC
CTGAAAATTCAGAATTGGCTCAAGCATTTGAAGAAGCTAAACAAATTAAGAAAAATCCTTCAAATTATAAATCGTACAGT
AGTCCAGAAGAAATGTTTAAAGATGTCTTGGGAGAAGATTATGAGGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A120KP40

Antitoxin

Source ID Structure
AlphaFold DB A0A109W6W6

References