Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1118235..1118824 Replicon chromosome
Accession NZ_CP014229
Organism Desulfovibrio fairfieldensis strain CCUG 45958

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AXF13_RS15800 Protein ID WP_083521959.1
Coordinates 1118570..1118824 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A109W3Z3
Locus tag AXF13_RS04840 Protein ID WP_062251864.1
Coordinates 1118235..1118573 (-) Length 113 a.a.

Genomic Context

AXF13_RS04800AXF13_RS04805AXF13_RS04810AXF13_RS04815AXF13_RS04820AXF13_RS04825AXF13_RS04830AXF13_RS04835AXF13_RS04845AXF13_RS04850AXF13_RS04840AXF13_RS15800
Location: 1113863..1114162 (300 bp)
Type: Others
Protein ID: WP_062251856.1
Location: 1114299..1114877 (579 bp)
Type: Others
Protein ID: WP_062251857.1
Location: 1114880..1115254 (375 bp)
Type: Others
Protein ID: WP_062251858.1
Location: 1115251..1115676 (426 bp)
Type: Others
Protein ID: WP_062251859.1
Location: 1115673..1116095 (423 bp)
Type: Others
Protein ID: WP_062251860.1
Location: 1116098..1117360 (1263 bp)
Type: Others
Protein ID: WP_083521958.1
Location: 1117380..1117772 (393 bp)
Type: Others
Protein ID: WP_062251862.1
Location: 1117793..1118140 (348 bp)
Type: Others
Protein ID: WP_150116075.1
Location: 1119001..1122855 (3855 bp)
Type: Others
Protein ID: WP_062251865.1
Location: 1122852..1123478 (627 bp)
Type: Others
Protein ID: WP_062251866.1
Location: 1118235..1118573 (339 bp)
Type: Antitoxin
Protein ID: WP_062251864.1
Location: 1118570..1118824 (255 bp)
Type: Toxin
Protein ID: WP_083521959.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AXF13_RS048001113863..1114162+300WP_062251856.1SAP domain-containing protein-
AXF13_RS048051114299..1114877+579WP_062251857.1hypothetical protein-
AXF13_RS048101114880..1115254+375WP_062251858.1hypothetical protein-
AXF13_RS048151115251..1115676+426WP_062251859.1hypothetical protein-
AXF13_RS048201115673..1116095+423WP_062251860.1hypothetical protein-
AXF13_RS048251116098..1117360+1263WP_083521958.1Ig-like domain-containing protein-
AXF13_RS048301117380..1117772+393WP_062251862.1hypothetical protein-
AXF13_RS048351117793..1118140+348WP_150116075.1hypothetical protein-
AXF13_RS048401118235..1118573-339WP_062251864.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
AXF13_RS158001118570..1118824-255WP_083521959.1type II toxin-antitoxin system HicA family toxinToxin
AXF13_RS048451119001..1122855+3855WP_062251865.1phage tail tape measure protein-
AXF13_RS048501122852..1123478+627WP_062251866.1DUF1833 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1067785..113348465699


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(56-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9502.92 Da        Isoelectric Point: 10.5888

>T60423 WP_083521959.1 NZ_CP014229:c1118824-1118570 [Desulfovibrio fairfieldensis]
MKRKHAAILAQIFARPVPGSVRWTDIESLFTELGAEIAEREGSRVSVFLFGEVRVFHRPHPTPDTDKGAVNSIRKWLEQH
GVKP

Download         Length: 255 bp

>T60423 NZ_CP014229:c1118824-1118570 [Desulfovibrio fairfieldensis]
ATGAAACGCAAACATGCCGCCATACTTGCGCAAATCTTCGCCCGCCCTGTGCCCGGAAGCGTTCGCTGGACAGATATTGA
GAGTCTTTTTACCGAGTTAGGCGCGGAGATTGCAGAACGTGAAGGTTCTCGCGTGAGTGTGTTTTTGTTCGGCGAAGTGC
GGGTATTTCATCGCCCGCACCCCACCCCGGACACGGATAAAGGGGCGGTAAACAGCATCAGAAAATGGCTGGAACAGCAC
GGAGTGAAGCCATGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12353.91 Da        Isoelectric Point: 4.9249

>AT60423 WP_062251864.1 NZ_CP014229:c1118573-1118235 [Desulfovibrio fairfieldensis]
MKNIMDFDGGYKAVIAYDPEIEMFRGEFIGLNGGADFYAKDLEGLRREGAESLRAFLEECERHGISPHKSHKGNFALRLD
PEIYQQASIAAAAEGKSLNTFITDVVRQAVAG

Download         Length: 339 bp

>AT60423 NZ_CP014229:c1118573-1118235 [Desulfovibrio fairfieldensis]
ATGAAAAATATTATGGATTTTGACGGCGGCTACAAAGCTGTCATTGCATACGACCCGGAAATCGAAATGTTTCGGGGTGA
ATTTATAGGCCTGAACGGTGGCGCTGACTTCTACGCCAAAGACCTTGAAGGACTGCGGCGTGAAGGGGCAGAGTCGTTGC
GAGCGTTTTTGGAAGAGTGCGAACGCCACGGCATCAGCCCACACAAGAGCCACAAAGGGAATTTTGCGTTGCGGCTGGAC
CCGGAAATATACCAGCAAGCCAGCATCGCGGCGGCAGCGGAAGGTAAGTCATTGAATACCTTCATTACAGATGTCGTGCG
TCAAGCGGTGGCAGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A109W3Z3

References