Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1170992..1171511 Replicon chromosome
Accession NZ_CP014228
Organism Actinomyces radicidentis strain CCUG 36733

Toxin (Protein)


Gene name relE Uniprot ID A0A0X8JDW1
Locus tag AXF14_RS04905 Protein ID WP_067941320.1
Coordinates 1170992..1171252 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0X8JDU6
Locus tag AXF14_RS04910 Protein ID WP_067941322.1
Coordinates 1171254..1171511 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXF14_RS04890 1166872..1168098 + 1227 WP_067941314.1 HipA domain-containing protein -
AXF14_RS13585 1168127..1170340 - 2214 WP_150118421.1 hypothetical protein -
AXF14_RS04905 1170992..1171252 - 261 WP_067941320.1 Txe/YoeB family addiction module toxin Toxin
AXF14_RS04910 1171254..1171511 - 258 WP_067941322.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AXF14_RS04915 1171662..1173566 + 1905 WP_150118422.1 glycoside hydrolase family 13 protein -
AXF14_RS04920 1173708..1175540 - 1833 WP_067941327.1 carbohydrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10325.51 Da        Isoelectric Point: 6.2171

>T60420 WP_067941320.1 NZ_CP014228:c1171252-1170992 [Actinomyces radicidentis]
MSLVWDDDAWEDYLWWQSSDRSVVKRINRLLRDVQRGGHEGIGTPEPLRFQLSGYWSRRITDEHRLVYRIADNGDVLIAS
CRYHYE

Download         Length: 261 bp

>T60420 NZ_CP014228:c1171252-1170992 [Actinomyces radicidentis]
ATGTCGCTCGTCTGGGACGACGACGCCTGGGAGGACTACCTGTGGTGGCAGTCCTCGGACCGCAGCGTCGTCAAGCGGAT
CAACCGCCTCCTGCGCGACGTCCAGCGCGGCGGCCACGAGGGTATCGGCACGCCCGAGCCGCTGCGCTTCCAGCTCTCCG
GGTACTGGTCACGGCGCATCACCGACGAGCACCGCCTCGTCTACCGCATCGCTGACAACGGCGACGTCCTCATTGCCTCG
TGCCGGTACCACTACGAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9653.75 Da        Isoelectric Point: 4.4442

>AT60420 WP_067941322.1 NZ_CP014228:c1171511-1171254 [Actinomyces radicidentis]
MKTMTYTESRARYAEVLDSVVDDREEVVITRAGHEPAVIVSLAEYQSLKETDYLLRSPANARRLLDAMERLENGRGTVHE
LDDAD

Download         Length: 258 bp

>AT60420 NZ_CP014228:c1171511-1171254 [Actinomyces radicidentis]
ATGAAGACGATGACCTACACCGAGTCACGCGCCCGCTACGCCGAGGTGCTCGACTCCGTCGTCGACGACCGCGAGGAAGT
CGTCATCACCCGCGCCGGCCACGAGCCCGCCGTCATCGTCTCCCTCGCCGAGTACCAGTCCCTCAAGGAGACGGACTACC
TCCTGCGCAGCCCCGCCAACGCGCGGCGCCTCCTCGACGCCATGGAGCGCCTCGAGAACGGCCGCGGCACCGTCCACGAG
CTCGACGACGCCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8JDW1

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8JDU6

References