Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 153450..154004 Replicon chromosome
Accession NZ_CP014228
Organism Actinomyces radicidentis strain CCUG 36733

Toxin (Protein)


Gene name mazF Uniprot ID A0A0X8JCK3
Locus tag AXF14_RS00710 Protein ID WP_067939109.1
Coordinates 153450..153767 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0X8JCJ4
Locus tag AXF14_RS00715 Protein ID WP_067939113.1
Coordinates 153771..154004 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXF14_RS00680 148660..149157 + 498 WP_067939090.1 MFS transporter -
AXF14_RS00685 149161..149541 + 381 WP_067939093.1 hypothetical protein -
AXF14_RS00690 149533..150843 - 1311 WP_067939096.1 hypothetical protein -
AXF14_RS00695 150899..151801 + 903 WP_067939099.1 ABC transporter ATP-binding protein -
AXF14_RS00700 151798..152556 + 759 WP_067939102.1 ABC transporter permease -
AXF14_RS00705 152543..153439 + 897 WP_150118373.1 hypothetical protein -
AXF14_RS00710 153450..153767 - 318 WP_067939109.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AXF14_RS00715 153771..154004 - 234 WP_067939113.1 hypothetical protein Antitoxin
AXF14_RS00720 154136..154831 + 696 WP_067939117.1 NADP-dependent oxidoreductase -
AXF14_RS00725 154901..155701 - 801 WP_067939120.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-93)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11168.11 Da        Isoelectric Point: 6.9781

>T60419 WP_067939109.1 NZ_CP014228:c153767-153450 [Actinomyces radicidentis]
VREVCLARLDKTRPVVVLTREPARPAMTKVTVAPITSTIKGLSSEVPVGPLNGLDHDSVISLDNVLTIPASALGRSLGVL
TTEQERALARAIVLAYDLDLPLMSI

Download         Length: 318 bp

>T60419 NZ_CP014228:c153767-153450 [Actinomyces radicidentis]
GTGAGGGAGGTCTGCCTCGCCCGCCTCGACAAGACGCGGCCCGTCGTCGTCCTCACTCGCGAGCCGGCGCGACCGGCCAT
GACGAAGGTGACCGTCGCGCCGATCACCTCGACCATCAAGGGGCTCTCGAGCGAGGTCCCGGTCGGCCCGCTCAACGGTC
TCGACCATGACTCCGTCATCAGTCTCGACAACGTCCTCACGATCCCGGCGTCTGCGCTCGGGAGGAGCCTCGGCGTGCTC
ACCACTGAGCAGGAGCGGGCGCTCGCGCGAGCAATCGTGCTCGCCTACGACCTCGACCTGCCGCTCATGAGCATCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8338.35 Da        Isoelectric Point: 4.0721

>AT60419 WP_067939113.1 NZ_CP014228:c154004-153771 [Actinomyces radicidentis]
MTVQIAVRLPDDVVGFLDEAVAAGDAPSRASIVTEALEREMRRRAAERDAELLREKGTGDDLDGLVAWTGAQPMIED

Download         Length: 234 bp

>AT60419 NZ_CP014228:c154004-153771 [Actinomyces radicidentis]
ATGACCGTTCAGATCGCCGTCCGCCTGCCCGATGACGTCGTCGGCTTCCTCGACGAGGCCGTGGCCGCCGGTGACGCCCC
CAGCCGCGCCTCAATCGTGACCGAGGCGCTCGAGCGCGAGATGCGCCGTCGGGCTGCTGAGCGCGACGCCGAGCTCCTTC
GTGAGAAGGGCACCGGCGATGACCTCGACGGGCTCGTAGCCTGGACCGGAGCCCAGCCGATGATCGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8JCK3

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8JCJ4

References