60417

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 3381727..3382084 Replicon chromosome
Accession NZ_CP014226
Organism Halomonas chromatireducens strain AGD 8-3

Toxin (Protein)


Gene name EcnB Uniprot ID A0A0X8HGK5
Locus tag LOKO_RS15630 Protein ID WP_066451443.1
Coordinates 3381727..3381858 (-) Length 44 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID A0A0X8HGH3
Locus tag LOKO_RS15635 Protein ID WP_066451445.1
Coordinates 3381953..3382084 (-) Length 44 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOKO_RS15605 3376855..3378150 + 1296 WP_066452402.1 MATE family efflux transporter -
LOKO_RS15610 3378269..3379579 + 1311 WP_066451437.1 short-chain fatty acid transporter -
LOKO_RS15615 3379688..3380215 + 528 WP_066451440.1 acyl-CoA thioesterase -
LOKO_RS15620 3380251..3381258 + 1008 WP_066451441.1 hypothetical protein -
LOKO_RS15625 3381277..3381543 - 267 WP_066452403.1 hypothetical protein -
LOKO_RS15630 3381727..3381858 - 132 WP_066451443.1 entericidin A/B family lipoprotein Toxin
LOKO_RS15635 3381953..3382084 - 132 WP_066451445.1 entericidin A/B family lipoprotein Antitoxin
LOKO_RS15640 3382259..3382726 + 468 WP_066451448.1 HIT domain-containing protein -
LOKO_RS15645 3382688..3383752 - 1065 WP_066451450.1 nickel/cobalt transporter -
LOKO_RS15650 3383743..3384402 - 660 WP_066451453.1 DUF1007 family protein -
LOKO_RS15655 3384489..3384845 - 357 WP_066451455.1 hypothetical protein -
LOKO_RS15660 3384845..3385396 - 552 WP_083517624.1 hypothetical protein -
LOKO_RS15665 3385745..3386218 + 474 WP_066451461.1 DNA starvation/stationary phase protection protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 44 a.a.        Molecular weight: 4310.90 Da        Isoelectric Point: 4.2289

>T60417 WP_066451443.1 NZ_CP014226:c3381858-3381727 [Halomonas chromatireducens]
MKRAIALSFALLMTAGALAGCNTMQGAGEDVERGGQAVQDAAD

Download         Length: 132 bp

>T60417 NZ_CP014226:c3381858-3381727 [Halomonas chromatireducens]
ATGAAGAGAGCCATTGCCCTTAGCTTTGCCCTGCTGATGACCGCCGGTGCCCTCGCAGGCTGCAACACCATGCAAGGTGC
CGGAGAGGATGTGGAGCGCGGCGGACAGGCTGTACAGGATGCCGCCGATTAA

Antitoxin


Download         Length: 44 a.a.        Molecular weight: 4634.47 Da        Isoelectric Point: 7.9985

>AT60417 WP_066451445.1 NZ_CP014226:c3382084-3381953 [Halomonas chromatireducens]
MKRILPMLLVSLFALSLLSGCNTMRGAGEDIERGGEAIQRQAS

Download         Length: 132 bp

>AT60417 NZ_CP014226:c3382084-3381953 [Halomonas chromatireducens]
ATGAAACGGATACTACCCATGTTGCTGGTTTCGCTCTTTGCCCTGTCACTGCTGAGTGGCTGCAACACCATGCGTGGCGC
GGGCGAGGATATCGAAAGAGGCGGCGAGGCGATTCAGCGCCAGGCAAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8HGK5

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8HGH3

References