Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 2558462..2558967 Replicon chromosome
Accession NZ_CP014226
Organism Halomonas chromatireducens strain AGD 8-3

Toxin (Protein)


Gene name relE Uniprot ID A0A0X8HF87
Locus tag LOKO_RS11895 Protein ID WP_066449437.1
Coordinates 2558713..2558967 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A109UM34
Locus tag LOKO_RS11890 Protein ID WP_066449434.1
Coordinates 2558462..2558716 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOKO_RS11875 2556302..2556520 - 219 WP_027962492.1 hypothetical protein -
LOKO_RS11880 2556853..2557275 + 423 WP_066449428.1 phasin family protein -
LOKO_RS11885 2557440..2558318 + 879 WP_158509943.1 alpha/beta hydrolase -
LOKO_RS11890 2558462..2558716 + 255 WP_066449434.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LOKO_RS11895 2558713..2558967 + 255 WP_066449437.1 Txe/YoeB family addiction module toxin Toxin
LOKO_RS11900 2558982..2559332 - 351 WP_066449439.1 hypothetical protein -
LOKO_RS11905 2559342..2559725 - 384 WP_201025317.1 DUF1311 domain-containing protein -
LOKO_RS11910 2559770..2561257 - 1488 WP_066449443.1 restriction endonuclease subunit S -
LOKO_RS11915 2561254..2562897 - 1644 WP_066449447.1 N-6 DNA methylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10257.84 Da        Isoelectric Point: 9.8548

>T60416 WP_066449437.1 NZ_CP014226:2558713-2558967 [Halomonas chromatireducens]
MKLTFSEHAWEEYLYWQKTDKKVLRRINQLIKEIQRTPFEGIGKPEPLKHGLAGYWSRRINDEHRIVYKVTEDALLIAQL
RYHY

Download         Length: 255 bp

>T60416 NZ_CP014226:2558713-2558967 [Halomonas chromatireducens]
ATGAAGCTGACATTCTCCGAGCACGCCTGGGAGGAGTATCTCTACTGGCAGAAGACCGACAAGAAGGTGCTCCGCAGAAT
CAATCAGCTCATCAAGGAGATCCAGCGCACCCCCTTCGAGGGCATCGGCAAGCCGGAACCGTTGAAACACGGCCTGGCAG
GCTACTGGTCTCGCAGAATCAACGACGAGCACCGTATCGTTTACAAGGTCACGGAGGATGCGCTGTTGATTGCACAGCTG
CGCTATCACTACTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9576.81 Da        Isoelectric Point: 4.5317

>AT60416 WP_066449434.1 NZ_CP014226:2558462-2558716 [Halomonas chromatireducens]
VEAISYTAARTHLAKTMQQVCEDHAPVIITRSRADSVVMMSLEDYEALQETAYLLRSPKNARRLLESIAQLEDDKGQERE
LIEE

Download         Length: 255 bp

>AT60416 NZ_CP014226:2558462-2558716 [Halomonas chromatireducens]
GTGGAAGCCATCAGCTACACCGCCGCCCGCACCCATCTGGCCAAGACCATGCAACAGGTCTGCGAGGACCATGCGCCGGT
GATCATCACTCGCAGCAGAGCCGACTCCGTGGTGATGATGTCGCTGGAGGACTACGAAGCCCTTCAGGAAACCGCTTACC
TGCTGCGCTCGCCAAAGAACGCCCGCCGCCTGCTCGAATCCATCGCCCAACTGGAAGATGACAAGGGTCAGGAGCGGGAG
CTCATCGAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8HF87

Antitoxin

Source ID Structure
AlphaFold DB A0A109UM34

References