Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 369388..369974 Replicon chromosome
Accession NZ_CP014226
Organism Halomonas chromatireducens strain AGD 8-3

Toxin (Protein)


Gene name hicA Uniprot ID A0A2A2F0A2
Locus tag LOKO_RS01815 Protein ID WP_066444310.1
Coordinates 369720..369974 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0X8HBK9
Locus tag LOKO_RS01810 Protein ID WP_066444299.1
Coordinates 369388..369723 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOKO_RS01790 364733..365479 - 747 WP_066452168.1 potassium channel family protein -
LOKO_RS19735 365722..365916 + 195 WP_066444288.1 hypothetical protein -
LOKO_RS01800 366415..368358 + 1944 WP_066444295.1 AAA family ATPase -
LOKO_RS01805 368482..369117 - 636 Protein_361 phosphatase PAP2 family protein -
LOKO_RS18510 369268..369345 - 78 WP_083517676.1 hypothetical protein -
LOKO_RS01810 369388..369723 - 336 WP_066444299.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOKO_RS01815 369720..369974 - 255 WP_066444310.1 type II toxin-antitoxin system HicA family toxin Toxin
LOKO_RS01820 370080..372527 - 2448 WP_066444315.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9363.67 Da        Isoelectric Point: 10.1785

>T60415 WP_066444310.1 NZ_CP014226:c369974-369720 [Halomonas chromatireducens]
MKRKHAKTLAAIFSRPTPGSIPWSDIESLFRALGADIQEREGSRIAVVLFGEVRVFHRPHPSPDTDKGAVASIRKWLEEN
GETP

Download         Length: 255 bp

>T60415 NZ_CP014226:c369974-369720 [Halomonas chromatireducens]
ATGAAACGAAAACACGCCAAGACGCTGGCCGCCATCTTCAGCCGACCTACGCCGGGATCGATCCCCTGGAGCGACATCGA
GTCGCTGTTTAGGGCGCTGGGCGCAGACATCCAGGAACGGGAGGGCTCGCGTATCGCCGTTGTGCTGTTTGGCGAGGTGC
GCGTGTTCCATCGGCCCCACCCCTCACCGGATACCGACAAGGGCGCAGTGGCCAGCATCCGCAAGTGGTTGGAAGAGAAC
GGAGAGACCCCGTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12327.80 Da        Isoelectric Point: 4.5822

>AT60415 WP_066444299.1 NZ_CP014226:c369723-369388 [Halomonas chromatireducens]
VNNIMIIDGYRAVIQYDPDIEMFRGEFTGLNGGADFYADSVAKLREEGGVSLRVFLDECRERGIEPTKSYSGKFQVRLPE
ELHKNAVDAATAKGQSLNQFVATAIEHELST

Download         Length: 336 bp

>AT60415 NZ_CP014226:c369723-369388 [Halomonas chromatireducens]
GTGAACAACATCATGATCATCGACGGCTATCGCGCCGTCATCCAGTACGACCCGGATATCGAGATGTTCCGCGGTGAGTT
TACTGGCCTTAACGGCGGTGCCGACTTCTACGCCGACAGCGTGGCCAAGCTGCGTGAGGAAGGCGGTGTTTCGCTGCGCG
TTTTCCTTGATGAGTGTCGGGAGCGAGGCATCGAGCCCACTAAGTCCTACTCCGGTAAGTTCCAGGTGCGCCTGCCTGAA
GAGCTGCACAAGAACGCCGTCGATGCCGCCACCGCCAAGGGGCAGAGCCTCAATCAGTTCGTGGCCACCGCCATCGAGCA
CGAGCTTTCGACGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2F0A2

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8HBK9

References