60370

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 2819034..2819511 Replicon chromosome
Accession NZ_CP014222
Organism Janthinobacterium sp. B9-8

Toxin (Protein)


Gene name pasB Uniprot ID A0A0X8GN96
Locus tag VN23_RS12620 Protein ID WP_046352216.1
Coordinates 2819242..2819511 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A0X8GNT5
Locus tag VN23_RS12615 Protein ID WP_046352215.1
Coordinates 2819034..2819258 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VN23_RS21550 2814083..2814199 + 117 WP_082752774.1 GpE family phage tail protein -
VN23_RS12595 2814203..2814916 + 714 WP_046352211.1 site-specific DNA-methyltransferase -
VN23_RS12600 2814916..2817504 + 2589 WP_046352212.1 phage tail tape measure protein -
VN23_RS12605 2817504..2817914 + 411 WP_046352213.1 phage tail protein -
VN23_RS12610 2817911..2818966 + 1056 WP_046352214.1 phage late control D family protein -
VN23_RS12615 2819034..2819258 + 225 WP_046352215.1 TraY domain-containing protein Antitoxin
VN23_RS12620 2819242..2819511 + 270 WP_046352216.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VN23_RS12625 2819918..2820370 - 453 WP_082752775.1 helix-turn-helix transcriptional regulator -
VN23_RS12630 2820412..2820693 + 282 WP_046352217.1 hypothetical protein -
VN23_RS12635 2820804..2821061 + 258 WP_156455198.1 hypothetical protein -
VN23_RS12640 2821143..2821604 + 462 WP_046352219.1 hypothetical protein -
VN23_RS12645 2821601..2823508 + 1908 WP_052746616.1 replication endonuclease -
VN23_RS12650 2823590..2823829 + 240 WP_046352220.1 hypothetical protein -
VN23_RS12655 2823990..2824220 + 231 WP_046352221.1 DUF4224 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2796365..2876946 80581


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

Relaxosome protein TraY

(4-49)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10305.02 Da        Isoelectric Point: 10.2886

>T60370 WP_046352216.1 NZ_CP014222:2819242-2819511 [Janthinobacterium sp. B9-8]
MAWLIKLDEEAQKDLAKLDKQVARRITAFLRERVATLEDPRSIGEALKGSKLGEFWKYRVGDYRLISSIEDGALRILVVK
IGNRREVYK

Download         Length: 270 bp

>T60370 NZ_CP014222:2819242-2819511 [Janthinobacterium sp. B9-8]
TTGGCTTGGCTGATTAAACTGGATGAAGAAGCTCAGAAAGATCTAGCCAAACTAGATAAACAAGTAGCACGACGAATTAC
GGCTTTTTTACGGGAGCGGGTAGCAACGCTAGAAGATCCACGCAGCATTGGTGAAGCCTTAAAAGGCTCTAAGCTCGGTG
AATTCTGGAAGTACCGCGTGGGTGATTACCGACTTATCAGCAGCATAGAAGATGGCGCATTGCGCATACTGGTTGTGAAA
ATAGGTAATCGACGTGAAGTGTACAAATAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8394.50 Da        Isoelectric Point: 4.7769

>AT60370 WP_046352215.1 NZ_CP014222:2819034-2819258 [Janthinobacterium sp. B9-8]
MLAIRLPAEIESRLDFLAKSTGRTKTFYAKEAILQHLDDLEDLYLAEQRLSAIHSGQSKTYSLEEVERNLGLAD

Download         Length: 225 bp

>AT60370 NZ_CP014222:2819034-2819258 [Janthinobacterium sp. B9-8]
ATGTTAGCAATCAGACTACCTGCCGAGATAGAAAGTCGCTTAGATTTTTTAGCGAAGAGTACCGGCAGGACTAAAACATT
TTACGCCAAAGAGGCCATTCTTCAGCATCTGGATGATTTAGAAGACCTCTATCTGGCCGAACAACGCTTAAGTGCCATCC
ACTCTGGGCAAAGTAAAACCTATAGTTTAGAAGAAGTGGAGCGCAACCTTGGCTTGGCTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8GN96

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8GNT5

References