Detailed information of TA system TA060369

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1803352..1803884
• Replicon: chromosome
• Accession: NZ_CP014222
• Organism: Janthinobacterium sp. B9-8

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: VN23_RS08075
• Protein ID: WP_197433057.1
• Coordinates: 1803352..1803654 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0X8GQG8
• Locus tag: VN23_RS08080
• Protein ID: WP_046353087.1
• Coordinates: 1803651..1803884 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VN23_RS08055	1798964..1800940	+	1977	WP_046352879.1	heme lyase CcmF/NrfE family subunit	-
VN23_RS08060	1801165..1801683	+	519	WP_046352878.1	DsbE family thiol:disulfide interchange protein	-
VN23_RS08065	1801797..1802312	+	516	WP_197433056.1	cytochrome c-type biogenesis protein CcmH	-
VN23_RS08070	1802309..1803151	+	843	WP_046352877.1	c-type cytochrome biogenesis protein CcmI	-
VN23_RS08075	1803352..1803654	-	303	WP_197433057.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VN23_RS08080	1803651..1803884	-	234	WP_046353087.1	ribbon-helix-helix protein, CopG family	Antitoxin
VN23_RS08085	1804008..1805315	-	1308	WP_046352876.1	sigma-54 dependent transcriptional regulator	-
VN23_RS08090	1805312..1807138	-	1827	WP_046352875.1	sensor histidine kinase	-
VN23_RS08095	1807141..1807935	-	795	WP_046352874.1	ABC transporter ATP-binding protein	-
VN23_RS08100	1807938..1808759	-	822	WP_046352873.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-95)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11413.32 Da
• Isoelectric Point: 10.7894

>T60369 WP_197433057.1 NZ_CP014222:c1803654-1803352 [Janthinobacterium sp. B9-8]
MSKTNTLRLRWLRKAIANLDAEAEYIAQESPQVAAEMFAYVKAKVEGLANFPASGRPGRVPGTRELIIDRYPLLVPYRVV
GNELHVLRVFHTRRKPPLSW

Nucleotide

• Length: 303 bp

>T60369 NZ_CP014222:c1803654-1803352 [Janthinobacterium sp. B9-8]
TTGAGCAAAACCAACACCCTGCGGCTTAGGTGGCTGCGCAAGGCAATCGCTAATCTGGATGCCGAGGCGGAATATATCGC
ACAGGAAAGCCCGCAAGTCGCAGCCGAGATGTTTGCCTATGTGAAAGCCAAAGTTGAAGGCTTGGCCAATTTTCCAGCAT
CAGGCAGGCCGGGGCGCGTACCCGGTACGCGCGAGCTGATCATCGACCGATACCCCTTGCTGGTGCCCTATCGCGTAGTG
GGTAATGAATTGCATGTACTCAGAGTATTTCACACTCGCCGCAAGCCGCCGCTTAGCTGGTAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8476.57 Da
• Isoelectric Point: 4.1370

>AT60369 WP_046353087.1 NZ_CP014222:c1803884-1803651 [Janthinobacterium sp. B9-8]
MSMMSMRLPDELSQQLEALAVATGRSKSYLAGQAIRAFVEQETWQVKEIKAALQEADAGDFASDEEVAELSAKWQAL

Nucleotide

• Length: 234 bp

>AT60369 NZ_CP014222:c1803884-1803651 [Janthinobacterium sp. B9-8]
ATGAGCATGATGTCGATGCGTTTGCCAGATGAGTTAAGCCAGCAGCTGGAAGCGCTGGCTGTGGCGACCGGGCGTAGCAA
ATCTTATCTGGCTGGGCAGGCTATCCGAGCCTTTGTTGAGCAGGAAACTTGGCAGGTCAAGGAAATTAAAGCTGCGCTGC
AAGAGGCCGATGCGGGGGATTTTGCCAGTGACGAGGAAGTGGCTGAGCTAAGCGCAAAGTGGCAGGCACTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A0X8GQG8