Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2955301..2955965 Replicon chromosome
Accession NZ_CP014209
Organism Isoptericola dokdonensis DS-3

Toxin (Protein)


Gene name vapC Uniprot ID A0A161I8Y6
Locus tag I598_RS13630 Protein ID WP_068203422.1
Coordinates 2955301..2955690 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A168FPY7
Locus tag I598_RS13635 Protein ID WP_068203423.1
Coordinates 2955687..2955965 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I598_RS13610 2950856..2952229 - 1374 WP_083973310.1 glutamate-1-semialdehyde 2,1-aminomutase -
I598_RS13615 2952300..2953304 - 1005 WP_068203419.1 porphobilinogen synthase -
I598_RS13620 2953301..2954179 - 879 WP_068203420.1 uroporphyrinogen-III synthase -
I598_RS13625 2954176..2955204 - 1029 WP_068203421.1 hydroxymethylbilane synthase -
I598_RS13630 2955301..2955690 - 390 WP_068203422.1 type II toxin-antitoxin system VapC family toxin Toxin
I598_RS13635 2955687..2955965 - 279 WP_068203423.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
I598_RS13640 2956005..2957453 - 1449 WP_068203424.1 FAD-dependent oxidoreductase -
I598_RS13645 2957450..2958589 - 1140 WP_068203425.1 uroporphyrinogen decarboxylase -
I598_RS13650 2958639..2960024 + 1386 WP_068203426.1 glutamyl-tRNA reductase -
I598_RS13655 2960150..2960530 + 381 WP_068203427.1 SHOCT domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-123)

Antitoxin

Antitoxin VapB-like

(2-91)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14014.00 Da        Isoelectric Point: 4.7250

>T60360 WP_068203422.1 NZ_CP014209:c2955690-2955301 [Isoptericola dokdonensis DS-3]
VIVDTSAVVAVLLGEPPADRIVDLLIGREAAMSAATLTELGIVVGRLAPQQARRLDALLTEWQVEVVPFTAEHARIARDA
YRDYGRGSGHPARLNLGDCFAYALATERRDELLFVGDDFVRTDLRAALA

Download         Length: 390 bp

>T60360 NZ_CP014209:c2955690-2955301 [Isoptericola dokdonensis DS-3]
GTGATCGTCGACACCTCCGCGGTCGTCGCCGTGCTGCTCGGGGAGCCCCCGGCCGACCGGATCGTCGACCTGCTGATCGG
GCGGGAGGCCGCGATGTCGGCAGCCACCCTGACCGAGCTGGGGATCGTCGTCGGACGACTCGCCCCGCAGCAGGCCCGAC
GCCTCGACGCCCTGCTCACGGAGTGGCAGGTGGAGGTGGTGCCGTTCACCGCCGAGCACGCCCGCATCGCCCGCGACGCC
TACCGGGACTACGGCCGCGGCAGCGGGCACCCAGCACGGCTGAACCTCGGCGACTGCTTCGCGTACGCGCTCGCCACCGA
GCGCCGCGACGAGCTGTTGTTCGTCGGTGACGACTTCGTCCGCACCGACCTCCGCGCAGCGCTCGCCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10146.29 Da        Isoelectric Point: 5.7471

>AT60360 WP_068203423.1 NZ_CP014209:c2955965-2955687 [Isoptericola dokdonensis DS-3]
VSLNIKNEHTHALVRRLADLTGSSQTSAVEEAVQRRLDEVLAERAAATEDPTARRARVEAILAAARADLTDAERRLLRRA
DADLYDESGLPR

Download         Length: 279 bp

>AT60360 NZ_CP014209:c2955965-2955687 [Isoptericola dokdonensis DS-3]
GTGAGCCTGAACATCAAGAACGAGCACACGCACGCCCTGGTCCGCCGGCTCGCCGACCTCACCGGCTCCAGCCAGACGAG
CGCGGTCGAGGAGGCCGTGCAGCGTCGCCTGGACGAGGTCCTCGCCGAGCGCGCCGCGGCCACCGAGGACCCCACGGCAC
GCCGCGCCCGCGTCGAGGCGATCCTCGCCGCAGCCCGCGCCGACCTCACCGACGCCGAGCGGCGGCTGCTGCGCCGCGCC
GACGCCGACCTCTACGACGAGTCGGGGCTGCCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A161I8Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A168FPY7

References