Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2405436..2406073 Replicon chromosome
Accession NZ_CP014209
Organism Isoptericola dokdonensis DS-3

Toxin (Protein)


Gene name vapC Uniprot ID A0A161HRA5
Locus tag I598_RS11220 Protein ID WP_068203034.1
Coordinates 2405663..2406073 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A168FHT9
Locus tag I598_RS11215 Protein ID WP_068203033.1
Coordinates 2405436..2405666 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I598_RS11185 2400886..2401221 + 336 WP_068203028.1 helix-turn-helix transcriptional regulator -
I598_RS11190 2401223..2402215 + 993 WP_068203029.1 hypothetical protein -
I598_RS11195 2402296..2402931 + 636 WP_068203030.1 hypothetical protein -
I598_RS11200 2402969..2403583 - 615 WP_068205225.1 dihydrofolate reductase family protein -
I598_RS11205 2403635..2404279 - 645 WP_068203031.1 hypothetical protein -
I598_RS11210 2404399..2405370 + 972 WP_198155810.1 GlxA family transcriptional regulator -
I598_RS11215 2405436..2405666 + 231 WP_068203033.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I598_RS11220 2405663..2406073 + 411 WP_068203034.1 type II toxin-antitoxin system VapC family toxin Toxin
I598_RS11225 2406109..2407377 - 1269 WP_068203035.1 arginine deiminase -
I598_RS11230 2407400..2408992 - 1593 WP_198155811.1 basic amino acid/polyamine antiporter -
I598_RS11235 2408989..2409939 - 951 WP_068203037.1 sugar phosphate isomerase/epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(6-34)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14818.96 Da        Isoelectric Point: 4.9502

>T60359 WP_068203034.1 NZ_CP014209:2405663-2406073 [Isoptericola dokdonensis DS-3]
VNTLYLLDTNILIALLRDRGDAARRRLVEATGRVGVSTISEMELEYGIERSASPARNRQAVDELLSLVEVIDLDSLAAMH
AGRIRAVLAARGTPIGPYDALLAGHARSLGLVMVTNNVREFSRVPGLEVEDWLSEP

Download         Length: 411 bp

>T60359 NZ_CP014209:2405663-2406073 [Isoptericola dokdonensis DS-3]
GTGAACACCCTCTACCTGCTCGACACGAACATCCTCATCGCCCTGCTCCGCGACCGCGGCGACGCTGCCCGACGACGGCT
CGTGGAGGCGACCGGGCGCGTCGGCGTCTCGACGATCAGCGAGATGGAGCTCGAGTACGGGATCGAGCGGTCGGCGAGCC
CGGCCCGCAACCGTCAGGCCGTCGACGAGCTCCTGTCCCTCGTGGAGGTCATCGACCTCGACTCCCTCGCCGCGATGCAC
GCGGGCCGCATCCGCGCCGTCCTCGCCGCCCGCGGGACGCCGATCGGACCGTACGACGCCCTGCTCGCCGGGCACGCCCG
GTCGCTCGGGCTCGTCATGGTGACGAACAACGTCCGCGAGTTCTCCCGGGTCCCCGGGCTGGAGGTCGAGGACTGGTTGT
CCGAGCCCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.7833

>AT60359 WP_068203033.1 NZ_CP014209:2405436-2405666 [Isoptericola dokdonensis DS-3]
MRTTVFRNNRTQAVRLPKAVALPDDVREVDVRVVGRTRVIEPAGTGWDEWFDHGLRVGDDFLTDRDQGEADDRAGL

Download         Length: 231 bp

>AT60359 NZ_CP014209:2405436-2405666 [Isoptericola dokdonensis DS-3]
ATGCGCACGACGGTCTTTCGCAACAACCGGACGCAGGCGGTCAGGCTGCCCAAGGCGGTGGCTCTGCCGGACGACGTCCG
CGAGGTCGACGTGCGGGTCGTCGGGCGGACCCGTGTGATCGAGCCGGCCGGCACCGGCTGGGACGAGTGGTTCGATCACG
GCCTGCGCGTCGGCGACGACTTCCTGACGGACCGGGACCAGGGCGAGGCCGACGACCGGGCAGGGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A161HRA5

Antitoxin

Source ID Structure
AlphaFold DB A0A168FHT9

References