Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 3501865..3502455 Replicon chromosome
Accession NZ_CP014207
Organism Pantoea ananatis strain R100

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag AW734_RS16360 Protein ID WP_064373948.1
Coordinates 3501865..3502197 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag AW734_RS16365 Protein ID WP_014605554.1
Coordinates 3502198..3502455 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AW734_RS16335 3498344..3498598 - 255 WP_013026202.1 Arc family DNA-binding protein -
AW734_RS16340 3498672..3499376 - 705 WP_022623305.1 phosphohydrolase -
AW734_RS16345 3499988..3500665 + 678 WP_064373945.1 hypothetical protein -
AW734_RS16350 3500771..3501604 + 834 WP_064373946.1 DgsA anti-repressor MtfA -
AW734_RS16360 3501865..3502197 - 333 WP_064373948.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AW734_RS16365 3502198..3502455 - 258 WP_014605554.1 antitoxin Antitoxin
AW734_RS22730 3502803..3503008 - 206 Protein_3185 helix-turn-helix domain-containing protein -
AW734_RS23155 3503005..3503256 - 252 Protein_3186 hypothetical protein -
AW734_RS16375 3503509..3504471 - 963 WP_064373950.1 ferrochelatase -
AW734_RS16380 3505220..3506458 + 1239 WP_042678145.1 MFS transporter -
AW734_RS16385 3506746..3507172 - 427 Protein_3189 pentapeptide repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin

Antitoxin PemI-like

(4-83)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11958.74 Da        Isoelectric Point: 6.9807

>T60357 WP_064373948.1 NZ_CP014207:c3502197-3501865 [Pantoea ananatis]
MERGEIWLVSLDPIAGHEQSGRRPVLIVSPASFNQFTRLPLVVPVTNGGNFARAAGFTVSLDGAGTKTTGVIRCDQPRTL
DMEARNGKYLERIPEVIVNEVVARLEAILS

Download         Length: 333 bp

>T60357 NZ_CP014207:c3502197-3501865 [Pantoea ananatis]
ATGGAAAGAGGGGAAATCTGGCTCGTTTCACTAGATCCGATTGCCGGGCATGAACAAAGCGGAAGACGTCCAGTACTGAT
TGTTTCTCCGGCGTCCTTTAATCAGTTTACGCGGCTACCTTTGGTTGTTCCCGTGACCAACGGCGGAAACTTTGCCCGCG
CAGCGGGGTTTACTGTTTCACTGGATGGCGCAGGAACGAAAACAACGGGGGTAATTCGTTGTGACCAGCCCAGAACCCTT
GATATGGAAGCCCGGAACGGCAAATATCTTGAACGAATACCTGAAGTTATTGTGAATGAAGTGGTGGCCAGACTGGAGGC
CATTCTGAGCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9253.73 Da        Isoelectric Point: 4.5821

>AT60357 WP_014605554.1 NZ_CP014207:c3502455-3502198 [Pantoea ananatis]
MYTTRLKKVGGSVMLAVPPAVLKTLGLSTDSEVGMTIDSGCLIIEPQKRPRYSLEELLAQCDPHAEISEEGREWIDAPAV
GKELL

Download         Length: 258 bp

>AT60357 NZ_CP014207:c3502455-3502198 [Pantoea ananatis]
ATGTATACCACTCGTCTGAAAAAGGTTGGCGGATCTGTCATGCTGGCGGTCCCTCCCGCCGTGCTGAAAACGCTGGGGCT
GTCGACGGACAGCGAAGTGGGCATGACCATTGATAGTGGCTGCCTCATAATTGAACCTCAAAAACGTCCCCGCTATTCAC
TCGAAGAACTACTGGCGCAGTGCGATCCGCACGCTGAAATAAGCGAAGAGGGTCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGCTCCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References