Detailed information of TA system TA060336

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 4179716..4180275
• Replicon: chromosome
• Accession: NZ_CP014168
• Organism: Sphingomonas panacis strain DCY99

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A1B3ZE43
• Locus tag: J0A91_RS19175
• Protein ID: WP_069206233.1
• Coordinates: 4179716..4180009 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J0A91_RS19180
• Protein ID: WP_083224792.1
• Coordinates: 4179997..4180275 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J0A91_RS19145	4175659..4176768	-	1110	WP_069206230.1	IS630 family transposase	-
J0A91_RS19150	4176823..4177272	+	450	WP_083224790.1	recombinase family protein	-
J0A91_RS19155	4177296..4177673	+	378	WP_083224791.1	excalibur calcium-binding domain-containing protein	-
J0A91_RS19160	4177827..4178615	+	789	WP_150126980.1	hypothetical protein	-
J0A91_RS19165	4178831..4179229	+	399	WP_150126981.1	hypothetical protein	-
J0A91_RS19170	4179298..4179672	+	375	WP_150126982.1	hypothetical protein	-
J0A91_RS19175	4179716..4180009	-	294	WP_069206233.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J0A91_RS19180	4179997..4180275	-	279	WP_083224792.1	CopG family ribbon-helix-helix protein	Antitoxin
J0A91_RS19185	4180539..4181555	-	1017	WP_069207493.1	hypothetical protein	-
J0A91_RS19190	4181917..4182303	+	387	WP_069207494.1	NUDIX domain-containing protein	-
J0A91_RS19195	4182418..4182864	-	447	WP_206364929.1	GFA family protein	-
J0A91_RS19200	4182983..4183378	-	396	WP_069206235.1	GNAT family N-acetyltransferase	-
J0A91_RS19205	4183961..4184251	+	291	WP_206364930.1	hypothetical protein	-
J0A91_RS19210	4184239..4184424	+	186	WP_069206237.1	hypothetical protein	-
J0A91_RS19215	4184524..4184694	-	171	WP_169833170.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4000499..4228384	227885

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10816.48 Da
• Isoelectric Point: 9.7859

>T60336 WP_069206233.1 NZ_CP014168:c4180009-4179716 [Sphingomonas panacis]
VPRLIWTPNALANVQRLYRWLLPKDADAATHAVATIRAGVRILAASPGIGRPVEDMDPEYRKKLIDFGNSGYVALYRLDD
ETVAILAVRRQKEAGYP

Nucleotide

• Length: 294 bp

>T60336 NZ_CP014168:c4180009-4179716 [Sphingomonas panacis]
GTGCCACGTCTGATCTGGACGCCGAATGCGTTAGCCAATGTTCAGCGACTCTATCGCTGGCTCTTGCCCAAGGATGCCGA
CGCCGCAACGCACGCGGTTGCGACGATCCGGGCCGGGGTCAGGATTCTGGCGGCATCACCGGGCATAGGCCGTCCGGTGG
AAGATATGGACCCCGAGTATCGGAAAAAGCTGATCGACTTCGGCAACAGCGGCTATGTCGCCCTCTATCGCCTTGATGAC
GAGACGGTAGCGATCCTGGCTGTCCGCCGCCAAAAGGAGGCGGGCTATCCATAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10690.99 Da
• Isoelectric Point: 6.6425

>AT60336 WP_083224792.1 NZ_CP014168:c4180275-4179997 [Sphingomonas panacis]
VAAATSIKLDDARKGRVQHLADVRRRSSHWIMREAIAQYVEREEKRETFRQDAIRAWHEYQQTGLHLTLEEADAWLAKLE
AGEDAEPPKCHV

Nucleotide

• Length: 279 bp

>AT60336 NZ_CP014168:c4180275-4179997 [Sphingomonas panacis]
GTGGCAGCGGCAACATCAATAAAGCTCGATGATGCCCGTAAGGGGCGTGTCCAGCACCTTGCCGATGTGCGGCGGCGCAG
CTCGCATTGGATCATGCGCGAAGCTATCGCACAGTATGTCGAACGCGAGGAAAAACGCGAGACGTTCCGACAGGACGCTA
TACGGGCATGGCACGAATATCAGCAGACGGGCTTGCATCTGACGCTTGAGGAAGCCGATGCTTGGTTGGCGAAGCTCGAA
GCGGGCGAGGATGCGGAGCCGCCTAAGTGCCACGTCTGA

Structures

Toxin

• AlphaFold DB: A0A1B3ZE43