60335

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 3045541..3046199 Replicon chromosome
Accession NZ_CP014168
Organism Sphingomonas panacis strain DCY99

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B3ZBS1
Locus tag J0A91_RS14005 Protein ID WP_069205426.1
Coordinates 3045541..3045966 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B3ZBT0
Locus tag J0A91_RS14010 Protein ID WP_069205427.1
Coordinates 3045966..3046199 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0A91_RS13980 3041547..3042476 - 930 WP_069205423.1 N-acetyl-gamma-glutamyl-phosphate reductase -
J0A91_RS13985 3042473..3042754 - 282 WP_083224955.1 hypothetical protein -
J0A91_RS13990 3042750..3043106 - 357 WP_069207329.1 MarR family transcriptional regulator -
J0A91_RS13995 3043330..3043746 + 417 WP_206364908.1 preprotein translocase subunit SecG -
J0A91_RS14000 3043851..3045485 + 1635 WP_069205425.1 CTP synthase -
J0A91_RS14005 3045541..3045966 - 426 WP_069205426.1 PIN domain-containing protein Toxin
J0A91_RS14010 3045966..3046199 - 234 WP_069205427.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
J0A91_RS14015 3046306..3047691 - 1386 WP_069205428.1 RNB domain-containing ribonuclease -
J0A91_RS14020 3047816..3048289 - 474 WP_069207331.1 Hsp20 family protein -
J0A91_RS14025 3048549..3050984 + 2436 WP_069207332.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-114)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15584.74 Da        Isoelectric Point: 5.6046

>T60335 WP_069205426.1 NZ_CP014168:c3045966-3045541 [Sphingomonas panacis]
MAKPFFDTNILVYAFSDDARSTVAETLLAQGGDVSVQVLNEFTNVARRKLGFDWEQIRQALAAIRTLARAIHPIELETHT
DAIALAERHGFSFYDALIVASALRARCKILFSEDMHDGLVVGDGLRITNPFKPPSPERAAD

Download         Length: 426 bp

>T60335 NZ_CP014168:c3045966-3045541 [Sphingomonas panacis]
ATGGCGAAGCCGTTCTTCGACACGAATATTCTCGTTTACGCTTTCTCCGACGATGCGCGATCAACCGTGGCGGAAACGCT
GCTGGCGCAAGGCGGAGATGTCAGCGTTCAGGTCCTCAACGAGTTCACCAACGTCGCGCGTCGAAAGCTCGGCTTCGACT
GGGAGCAAATTCGGCAAGCCCTGGCGGCTATTCGAACGCTCGCACGGGCGATCCATCCCATCGAGCTCGAAACCCATACC
GATGCGATCGCACTGGCCGAGCGCCACGGCTTCTCGTTCTACGATGCGTTGATCGTCGCCTCGGCGCTGCGCGCGCGATG
CAAAATCCTGTTTTCGGAGGACATGCACGACGGGCTTGTCGTCGGTGATGGTCTGCGCATCACAAACCCATTCAAGCCAC
CAAGCCCCGAACGTGCGGCGGACTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8773.94 Da        Isoelectric Point: 6.3620

>AT60335 WP_069205427.1 NZ_CP014168:c3046199-3045966 [Sphingomonas panacis]
MQVTRWGNSLAIRLPAAVVEALALKEGDDIEVRIAGERTFLVERDRERAAALDSIRRLRRPLPAGWSFSREEANERD

Download         Length: 234 bp

>AT60335 NZ_CP014168:c3046199-3045966 [Sphingomonas panacis]
ATGCAGGTCACACGCTGGGGCAACAGCCTCGCAATCCGCCTTCCCGCTGCCGTCGTCGAGGCGCTGGCGCTCAAGGAAGG
CGACGACATCGAGGTTCGCATCGCGGGCGAACGGACGTTTCTCGTCGAACGGGATCGCGAACGCGCGGCTGCACTCGACA
GCATCCGCCGACTCCGTCGCCCGCTGCCGGCGGGCTGGAGTTTTTCGCGCGAAGAGGCGAACGAGCGGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B3ZBS1

Antitoxin

Source ID Structure
AlphaFold DB A0A1B3ZBT0

References