Detailed information of TA system TA060334

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1582540..1582997
• Replicon: chromosome
• Accession: NZ_CP014168
• Organism: Sphingomonas panacis strain DCY99

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J0A91_RS07185
• Protein ID: WP_069207125.1
• Coordinates: 1582719..1582997 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1B3Z8M5
• Locus tag: J0A91_RS07180
• Protein ID: WP_069204334.1
• Coordinates: 1582540..1582722 (+)
• Length: 61 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J0A91_RS07170	1580383..1581951	+	1569	WP_150126844.1	DUF262 domain-containing protein	-
J0A91_RS07175	1582035..1582313	-	279	WP_069204333.1	hypothetical protein	-
J0A91_RS07180	1582540..1582722	+	183	WP_069204334.1	stability determinant	Antitoxin
J0A91_RS07185	1582719..1582997	+	279	WP_069207125.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J0A91_RS07190	1583318..1583752	-	435	WP_069204335.1	UrcA family protein	-
J0A91_RS07195	1583946..1584512	+	567	WP_069204336.1	ATP-dependent protease subunit HslV	-
J0A91_RS07200	1584628..1585923	+	1296	WP_069204337.1	ATP-dependent protease ATPase subunit HslU	-
J0A91_RS07205	1585936..1586343	-	408	WP_069204338.1	hypothetical protein	-
J0A91_RS07210	1586383..1587117	-	735	WP_069204339.1	hydroxyacylglutathione hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10615.19 Da
• Isoelectric Point: 10.7496

>T60334 WP_069207125.1 NZ_CP014168:1582719-1582997 [Sphingomonas panacis]
MTRRVVWRAKARAQAREIIVYIADRNPAAAERLADRFEDAVDRLPDHPHVHRPGRVSGTREAIVHPNYIIIYRVGESVIE
VVAVLHARQRYP

Nucleotide

• Length: 279 bp

>T60334 NZ_CP014168:1582719-1582997 [Sphingomonas panacis]
CTGACGCGCCGCGTCGTTTGGCGCGCAAAGGCGCGGGCGCAGGCGCGCGAGATCATCGTTTACATCGCCGACCGGAACCC
CGCCGCCGCCGAGCGGCTCGCCGACCGTTTCGAAGACGCGGTCGATCGTCTACCCGATCACCCGCATGTCCATCGCCCCG
GTCGCGTGTCCGGCACGCGTGAGGCGATCGTCCATCCGAATTACATCATCATCTATCGGGTCGGTGAGTCGGTGATCGAG
GTAGTGGCGGTGCTACACGCCCGACAGCGATATCCCTGA

Antitoxin

Protein

• Length: 61 a.a.
• Molecular weight: 6676.61 Da
• Isoelectric Point: 4.6472

>AT60334 WP_069204334.1 NZ_CP014168:1582540-1582722 [Sphingomonas panacis]
MTKMTPIESEFATTEDEAAYDAWFRAKVEASLADPSPPIPHDQMMAELRAIIAARRTKPA

Nucleotide

• Length: 183 bp

>AT60334 NZ_CP014168:1582540-1582722 [Sphingomonas panacis]
ATGACGAAGATGACCCCCATCGAGTCCGAATTCGCCACCACCGAGGACGAAGCCGCCTATGATGCGTGGTTCCGCGCCAA
GGTCGAGGCCTCGCTTGCCGATCCGTCGCCGCCGATCCCCCACGATCAGATGATGGCGGAGCTCCGCGCCATCATCGCAG
CCAGGCGGACCAAACCGGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B3Z8M5