60333

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 269144..269684 Replicon chromosome
Accession NZ_CP014168
Organism Sphingomonas panacis strain DCY99

Toxin (Protein)


Gene name parE Uniprot ID A0A1B3Z5T6
Locus tag J0A91_RS01145 Protein ID WP_069203375.1
Coordinates 269144..269431 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1B3Z5T1
Locus tag J0A91_RS01150 Protein ID WP_069203376.1
Coordinates 269421..269684 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0A91_RS01130 264984..265937 + 954 WP_069203372.1 ferritin-like domain-containing protein -
J0A91_RS01135 266078..267013 + 936 WP_083224886.1 ferritin-like domain-containing protein -
J0A91_RS01140 267226..269103 + 1878 WP_069203374.1 phosphomethylpyrimidine synthase ThiC -
J0A91_RS01145 269144..269431 - 288 WP_069203375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J0A91_RS01150 269421..269684 - 264 WP_069203376.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
J0A91_RS01155 269755..269943 - 189 WP_069203377.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
J0A91_RS01160 269986..270621 - 636 WP_069203378.1 2-dehydro-3-deoxy-6-phosphogalactonate aldolase -
J0A91_RS01165 270631..271512 - 882 WP_069203379.1 2-dehydro-3-deoxygalactonokinase -
J0A91_RS01170 271509..272384 - 876 WP_069203380.1 SMP-30/gluconolactonase/LRE family protein -
J0A91_RS01175 272381..273577 - 1197 WP_150127047.1 sugar MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Antitoxin ParD

(7-76)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11327.01 Da        Isoelectric Point: 10.1290

>T60333 WP_069203375.1 NZ_CP014168:c269431-269144 [Sphingomonas panacis]
MRLELSRKAKADLDDIRDYSVQRFGEARAILYLDPIEQAFRRILQFPESGASRSDLSTELRSISVGRHRLYYRVYAERVR
IVRILHHAMEIERHL

Download         Length: 288 bp

>T60333 NZ_CP014168:c269431-269144 [Sphingomonas panacis]
ATGCGGCTTGAGCTGAGTCGCAAAGCGAAAGCGGACCTCGACGATATTCGCGATTACAGCGTGCAACGCTTCGGTGAAGC
GCGCGCGATTCTCTACCTCGACCCGATCGAGCAGGCGTTTCGACGCATTCTACAATTCCCTGAGAGCGGCGCATCCCGAT
CCGACCTCTCGACCGAATTGCGCAGCATCTCGGTCGGTCGTCACCGCCTCTATTACCGGGTATATGCGGAGCGCGTACGA
ATCGTGCGTATTCTCCATCATGCGATGGAGATCGAGCGGCACCTTTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9554.65 Da        Isoelectric Point: 4.5917

>AT60333 WP_069203376.1 NZ_CP014168:c269684-269421 [Sphingomonas panacis]
MAQMNISIPDKLKSWAERRVAEGDYSSTSDYVRDLVRRDQAAIEQLARLRAAIDEGIASGVSDRDPFAYLDELRAALTPV
RGSADAA

Download         Length: 264 bp

>AT60333 NZ_CP014168:c269684-269421 [Sphingomonas panacis]
ATGGCGCAGATGAACATCTCGATCCCCGACAAGCTCAAGAGCTGGGCGGAGCGGCGCGTCGCCGAGGGCGATTACAGCAG
TACCAGCGATTATGTGCGCGATCTGGTGCGGCGCGATCAGGCGGCGATCGAGCAGCTTGCGCGGTTGCGCGCGGCGATCG
ACGAGGGGATCGCGTCAGGGGTTAGCGATCGCGATCCCTTTGCGTATCTCGACGAGCTCAGAGCCGCACTGACCCCGGTT
CGCGGGAGCGCGGATGCGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B3Z5T6

Antitoxin

Source ID Structure
AlphaFold DB A0A1B3Z5T1

References