Detailed information of TA system TA060322

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 1778549..1778972
• Replicon: chromosome
• Accession: NZ_CP014163
• Organism: Aerococcus urinaehominis strain CCUG42038B

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AWM75_RS08660
• Protein ID: WP_074572649.1
• Coordinates: 1778817..1778972 (+)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A120IB32
• Locus tag: AWM75_RS08285
• Protein ID: WP_067980726.1
• Coordinates: 1778549..1778776 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AWM75_RS08265	1774127..1774612	+	486	WP_067980718.1	SUF system NifU family Fe-S cluster assembly protein	-
AWM75_RS08270	1774616..1776013	+	1398	WP_067980720.1	Fe-S cluster assembly protein SufB	-
AWM75_RS08770	1776422..1776631	+	210	WP_158320190.1	hypothetical protein	-
AWM75_RS08725	1776782..1776964	+	183	WP_158320193.1	hypothetical protein	-
AWM75_RS08275	1776978..1777172	-	195	WP_067980722.1	hypothetical protein	-
AWM75_RS08280	1777272..1778294	-	1023	WP_067980724.1	hypothetical protein	-
AWM75_RS08285	1778549..1778776	+	228	WP_067980726.1	translation repressor RelB	Antitoxin
AWM75_RS08660	1778817..1778972	+	156	WP_074572649.1	hypothetical protein	Toxin
AWM75_RS08665	1779330..1779497	+	168	WP_082702108.1	helix-turn-helix domain-containing protein	-
AWM75_RS08290	1779636..1782398	+	2763	WP_067980727.1	CRISPR-associated helicase/endonuclease Cas3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5929.02 Da
• Isoelectric Point: 10.4617

>T60322 WP_074572649.1 NZ_CP014163:1778817-1778972 [Aerococcus urinaehominis]
MNQHISIMLVKARVKELDGLEDPRSKGKALSSQLKGLWRYRVGQYRIICEI

Nucleotide

• Length: 156 bp

>T60322 NZ_CP014163:1778817-1778972 [Aerococcus urinaehominis]
ATGAACCAGCATATTTCAATTATGTTAGTGAAAGCAAGGGTGAAGGAATTAGATGGTTTAGAGGACCCGCGTTCAAAAGG
TAAGGCACTGTCTAGTCAGTTAAAAGGATTATGGCGCTATCGCGTTGGTCAATATCGTATTATCTGTGAGATATAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8531.49 Da
• Isoelectric Point: 3.9419

>AT60322 WP_067980726.1 NZ_CP014163:1778549-1778776 [Aerococcus urinaehominis]
MSVVSLRLNEEEEKLFKGYSQQTGKTLSELFKTALAEEIETELDYEIGVQALEAYRQDPVSSSIGEFIKELENDL

Nucleotide

• Length: 228 bp

>AT60322 NZ_CP014163:1778549-1778776 [Aerococcus urinaehominis]
ATGTCAGTAGTATCTCTTAGATTAAATGAAGAAGAGGAAAAGCTTTTTAAAGGGTATTCTCAGCAGACGGGTAAAACGCT
CTCAGAACTTTTTAAAACTGCACTGGCAGAAGAAATTGAAACGGAGCTAGATTATGAAATAGGCGTGCAGGCACTAGAAG
CTTATCGCCAAGATCCTGTTTCTAGCTCAATAGGTGAGTTTATTAAGGAATTGGAAAACGACCTATAG

Structures

Antitoxin

• AlphaFold DB: A0A120IB32