60321

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 152787..153275 Replicon chromosome
Accession NZ_CP014163
Organism Aerococcus urinaehominis strain CCUG42038B

Toxin (Protein)


Gene name relE Uniprot ID A0A109RHB7
Locus tag AWM75_RS00730 Protein ID WP_067977265.1
Coordinates 152787..153011 (-) Length 75 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X8FJX3
Locus tag AWM75_RS00735 Protein ID WP_067977266.1
Coordinates 153051..153275 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWM75_RS00725 151888..152634 - 747 WP_067977264.1 methylase -
AWM75_RS00730 152787..153011 - 225 WP_067977265.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AWM75_RS00735 153051..153275 - 225 WP_067977266.1 hypothetical protein Antitoxin
AWM75_RS00740 153345..153782 - 438 WP_067977267.1 Ohr family peroxiredoxin -
AWM75_RS00745 153934..154839 + 906 WP_067977268.1 acetamidase/formamidase family protein -
AWM75_RS00750 154879..156009 - 1131 WP_067977269.1 ArgE/DapE family deacylase -
AWM75_RS00755 156242..157285 - 1044 WP_067977270.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(24-74)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8888.28 Da        Isoelectric Point: 10.1954

>T60321 WP_067977265.1 NZ_CP014163:c153011-152787 [Aerococcus urinaehominis]
MLRKMDRHQAQLLVGWINKNLVGTNDPRQFGKALKGQYQDYWRYRIGNYRIIADILDDQIKINIIDVGHRKEIY

Download         Length: 225 bp

>T60321 NZ_CP014163:c153011-152787 [Aerococcus urinaehominis]
ATGTTAAGAAAAATGGATAGGCATCAAGCTCAGTTACTTGTTGGCTGGATTAATAAAAACCTCGTAGGGACTAACGATCC
ACGTCAATTTGGAAAGGCCCTAAAAGGTCAATACCAAGATTATTGGCGCTATCGAATTGGTAATTATCGTATTATTGCTG
ATATTTTGGATGATCAAATCAAAATTAATATTATCGATGTTGGTCATCGAAAAGAAATTTACTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8771.85 Da        Isoelectric Point: 4.1417

>AT60321 WP_067977266.1 NZ_CP014163:c153275-153051 [Aerococcus urinaehominis]
MSTVTVRLNTDEQKLFTEYAKMHDMPLSTLLKNALEERIEDEIDLKLIRDFENSPDYYDEEYLSHEEVSKMVGL

Download         Length: 225 bp

>AT60321 NZ_CP014163:c153275-153051 [Aerococcus urinaehominis]
ATGTCTACTGTAACTGTCAGATTAAATACGGATGAACAAAAATTATTTACTGAATACGCCAAAATGCATGATATGCCTCT
GTCTACACTATTAAAGAATGCTCTTGAAGAGCGTATTGAAGACGAAATTGACTTAAAATTGATTAGAGATTTTGAGAATT
CTCCAGATTATTATGATGAAGAATATTTGAGTCACGAAGAAGTAAGCAAGATGGTTGGACTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A109RHB7

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8FJX3

References