Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-MazE
Location 102915..103504 Replicon chromosome
Accession NZ_CP014161
Organism Aerococcus urinae strain CCUG36881

Toxin (Protein)


Gene name pemK Uniprot ID A0A0X8FD65
Locus tag AWM73_RS00450 Protein ID WP_060777568.1
Coordinates 103151..103504 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0X8FCZ2
Locus tag AWM73_RS00445 Protein ID WP_060777567.1
Coordinates 102915..103157 (+) Length 81 a.a.

Genomic Context

AWM73_RS00410AWM73_RS00415AWM73_RS00420AWM73_RS00425AWM73_RS00430AWM73_RS00435AWM73_RS00445AWM73_RS00450AWM73_RS00455AWM73_RS00460AWM73_RS00465AWM73_RS00470AWM73_RS00475AWM73_RS00440
Location: 98172..98717 (546 bp)
Type: Others
Protein ID: WP_060777561.1
Location: 98765..99379 (615 bp)
Type: Others
Protein ID: WP_060777562.1
Location: 99405..99911 (507 bp)
Type: Others
Protein ID: WP_060777563.1
Location: 100044..101180 (1137 bp)
Type: Others
Protein ID: WP_060777564.1
Location: 101354..101578 (225 bp)
Type: Others
Protein ID: WP_174519266.1
Location: 101619..101966 (348 bp)
Type: Others
Protein ID: WP_060777565.1
Location: 102915..103157 (243 bp)
Type: Antitoxin
Protein ID: WP_060777567.1
Location: 103151..103504 (354 bp)
Type: Toxin
Protein ID: WP_060777568.1
Location: 103732..104109 (378 bp)
Type: Others
Protein ID: WP_060777569.1
Location: 104102..104791 (690 bp)
Type: Others
Protein ID: WP_060777570.1
Location: 104788..105594 (807 bp)
Type: Others
Protein ID: WP_060777571.1
Location: 105607..106758 (1152 bp)
Type: Others
Protein ID: WP_060777572.1
Location: 107055..108449 (1395 bp)
Type: Others
Protein ID: WP_060777573.1
Location: 102092..102649 (558 bp)
Type: Others
Protein ID: WP_060777566.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AWM73_RS0041098172..98717+546WP_060777561.1hypothetical protein-
AWM73_RS0041598765..99379+615WP_060777562.1hypothetical protein-
AWM73_RS0042099405..99911+507WP_060777563.1hypothetical protein-
AWM73_RS00425100044..101180+1137WP_060777564.1hypothetical protein-
AWM73_RS00430101354..101578+225WP_174519266.1hypothetical protein-
AWM73_RS00435101619..101966+348WP_060777565.1hypothetical protein-
AWM73_RS00440102092..102649-558WP_060777566.1isochorismatase family protein-
AWM73_RS00445102915..103157+243WP_060777567.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
AWM73_RS00450103151..103504+354WP_060777568.1type II toxin-antitoxin system PemK/MazF family toxinToxin
AWM73_RS00455103732..104109+378WP_060777569.1GntR family transcriptional regulator-
AWM73_RS00460104102..104791+690WP_060777570.1ABC transporter ATP-binding protein-
AWM73_RS00465104788..105594+807WP_060777571.1hypothetical protein-
AWM73_RS00470105607..106758+1152WP_060777572.1hypothetical protein-
AWM73_RS00475107055..108449+1395WP_060777573.123S rRNA (uracil(1939)-C(5))-methyltransferase RlmD-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-99)

Antitoxin

Antitoxin PemI-like

(1-78)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13876.81 Da        Isoelectric Point: 8.0664

>T60316 WP_060777568.1 NZ_CP014161:103151-103504 [Aerococcus urinae]
MVMRQGDIFYVNFNPNIGHEQRNSRPAIVLSHDLIFQTSRMAIVAPISTTKRNYPAYYELQETDHTKGKVLLDQTKSLDL
YHCQVSQENFIERAKPNEFKRIIHRYKLLFDLVDDYQ

Download         Length: 354 bp

>T60316 NZ_CP014161:103151-103504 [Aerococcus urinae]
ATGGTAATGCGGCAGGGCGACATTTTTTACGTTAATTTTAATCCAAATATCGGGCACGAACAGAGAAATAGTCGTCCGGC
TATTGTATTAAGTCATGATCTCATTTTTCAGACGAGTCGAATGGCGATTGTTGCGCCTATCTCAACAACTAAACGAAATT
ATCCAGCCTATTATGAGCTTCAAGAGACTGACCATACCAAGGGTAAAGTTCTTTTGGATCAAACAAAGTCTCTTGATCTT
TATCATTGCCAAGTCAGCCAAGAAAATTTTATTGAACGAGCTAAACCGAATGAATTTAAGCGTATTATTCATCGTTATAA
ATTGTTATTCGATCTGGTAGATGATTATCAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9213.44 Da        Isoelectric Point: 4.1954

>AT60316 WP_060777567.1 NZ_CP014161:102915-103157 [Aerococcus urinae]
MQTKIAQWGNSKAIRIPSTIVKQLNLKDNQVLSLEIKDQALVIKPKEAETIQELFADYNTSFTYEEEMDWGPAVGEEIEW

Download         Length: 243 bp

>AT60316 NZ_CP014161:102915-103157 [Aerococcus urinae]
ATGCAAACTAAAATTGCTCAATGGGGGAATTCAAAGGCGATCAGAATCCCATCAACGATAGTTAAACAGCTCAATTTAAA
GGATAATCAAGTGCTCTCACTTGAAATCAAAGATCAGGCCCTAGTGATTAAGCCTAAGGAAGCAGAAACTATTCAGGAAT
TATTTGCTGATTACAACACTTCTTTCACTTATGAGGAAGAAATGGATTGGGGACCAGCAGTGGGAGAAGAGATCGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0X8FD65

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0X8FCZ2

References